(14 nodes) (2023) Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression. network (Oryctolagus cuniculus)

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Your Input:
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (741 aa)
	MED12	Mediator complex subunit 12. (2142 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (844 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
	MED23	Mediator complex subunit 23. (1552 aa)
	CTCF	CCCTC-binding factor. (738 aa)
	ND2	NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (843 aa)
	HNRNPL	Heterogeneous nuclear ribonucleoprotein L; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	DNMT3B	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (859 aa)
	AEBP2	AE binding protein 2. (319 aa)
	HNRNPK	Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is co [...] (463 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (367 aa)
	SETD2	Uncharacterized protein. (625 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEBP2	DNMT3A	ENSOCUP00000014337	ENSOCUP00000024004	AE binding protein 2.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.529
AEBP2	DNMT3B	ENSOCUP00000014337	ENSOCUP00000015318	AE binding protein 2.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.506
AEBP2	SUZ12	ENSOCUP00000014337	ENSOCUP00000002188	AE binding protein 2.	SUZ12 polycomb repressive complex 2 subunit.	0.999
CTCF	DNMT3A	ENSOCUP00000036313	ENSOCUP00000024004	CCCTC-binding factor.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.576
CTCF	DNMT3B	ENSOCUP00000036313	ENSOCUP00000015318	CCCTC-binding factor.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.425
CTCF	GAPDH	ENSOCUP00000036313	ENSOCUP00000044112	CCCTC-binding factor.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.603
CTCF	HNRNPU	ENSOCUP00000036313	ENSOCUP00000044849	CCCTC-binding factor.	Heterogeneous nuclear ribonucleoprotein U.	0.423
CTCF	MED12	ENSOCUP00000036313	ENSOCUP00000047946	CCCTC-binding factor.	Mediator complex subunit 12.	0.539
CTCF	SUZ12	ENSOCUP00000036313	ENSOCUP00000002188	CCCTC-binding factor.	SUZ12 polycomb repressive complex 2 subunit.	0.883
DNMT3A	AEBP2	ENSOCUP00000024004	ENSOCUP00000014337	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	AE binding protein 2.	0.529
DNMT3A	CTCF	ENSOCUP00000024004	ENSOCUP00000036313	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	CCCTC-binding factor.	0.576
DNMT3A	DNMT3B	ENSOCUP00000024004	ENSOCUP00000015318	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.993
DNMT3A	GAPDH	ENSOCUP00000024004	ENSOCUP00000044112	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.698
DNMT3A	SETD2	ENSOCUP00000024004	ENSOCUP00000002465	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.515
DNMT3A	SUZ12	ENSOCUP00000024004	ENSOCUP00000002188	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	SUZ12 polycomb repressive complex 2 subunit.	0.746
DNMT3B	AEBP2	ENSOCUP00000015318	ENSOCUP00000014337	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	AE binding protein 2.	0.506
DNMT3B	CTCF	ENSOCUP00000015318	ENSOCUP00000036313	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	CCCTC-binding factor.	0.425
DNMT3B	DNMT3A	ENSOCUP00000015318	ENSOCUP00000024004	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.993
DNMT3B	GAPDH	ENSOCUP00000015318	ENSOCUP00000044112	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...]	0.568
DNMT3B	SETD2	ENSOCUP00000015318	ENSOCUP00000002465	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.464