STRINGSTRING
MSN MSN FOSB FOSB MME MME CD38 CD38 JUN JUN EZR EZR CCND3 CCND3 IL7 IL7 RDX RDX CD19 CD19 CD79B CD79B CD34 CD34 BCR BCR IGHM-3 IGHM-3 MIF MIF FOS FOS RAG2 RAG2 RAG1 RAG1 INS INS IGHM-2 IGHM-2 IL6 IL6 IGLL1 IGLL1 ALB ALB PAX5 PAX5 FOXP3 FOXP3 EBF1 EBF1 G1SV95_RABIT G1SV95_RABIT CD27 CD27 TGFB2 TGFB2 BACH2 BACH2 CD74 CD74 CCR1 CCR1 CXCR4 CXCR4 LTBR LTBR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSNFERM domain-containing protein. (577 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (289 aa)
MMENeprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
CD38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. (299 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
EZREzrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (653 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (287 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
RDXRadixin. (643 aa)
CD19CD19 molecule. (573 aa)
CD79BCD79b molecule. (282 aa)
CD34CD34 molecule. (415 aa)
BCRBCR activator of RhoGEF and GTPase. (1192 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
MIFMacrophage migration inhibitory factor. (115 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
RAG2V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (527 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1128 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
IGLL1Lambda5. (208 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
PAX5Paired box 5. (371 aa)
FOXP3Forkhead box P3. (455 aa)
EBF1EBF transcription factor 1. (591 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
CD27CD27 molecule. (260 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BACH2BTB domain and CNC homolog 2. (774 aa)
CD74CD74 molecule. (375 aa)
CCR1Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LTBRLymphotoxin beta receptor. (414 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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