STRINGSTRING
MYC MYC RHOA RHOA MTOR MTOR KRAS KRAS G1SV95_RABIT G1SV95_RABIT COL4A4 COL4A4 EIF2AK2 EIF2AK2 ARID1A ARID1A TGFB2 TGFB2 ACTR3 ACTR3 SMARCD2 SMARCD2 IRF7 IRF7 SMARCC1 SMARCC1 ITGA6 ITGA6 ADAR ADAR IRF1 IRF1 CD9 CD9 GAPDH GAPDH IFNG IFNG ACTR2 ACTR2 MYD88 MYD88 TSG101 TSG101 IFIT3 IFIT3 ISG15 ISG15 MAVS MAVS IFIT2 IFIT2 ARPC1B ARPC1B DDX58 DDX58 MX2 MX2 ITGB5 ITGB5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
RHOARas homolog family member A. (193 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
COL4A4Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1687 aa)
EIF2AK2Interferon-induced double-stranded RNA-activated protein kinase. (547 aa)
ARID1AAT-rich interaction domain 1A. (2089 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (418 aa)
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2. (532 aa)
IRF7Interferon regulatory factor 7. (438 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1011 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (955 aa)
ADARAdenosine deaminase RNA specific. (1182 aa)
IRF1Interferon regulatory factor. (336 aa)
CD9Tetraspanin. (385 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (425 aa)
MYD88Uncharacterized protein. (476 aa)
TSG101Tumor susceptibility 101. (422 aa)
IFIT3Interferon induced protein with tetratricopeptide repeats 3. (484 aa)
ISG15ISG15 ubiquitin like modifier. (164 aa)
MAVSMitochondrial antiviral signaling protein. (541 aa)
IFIT2Interferon induced protein with tetratricopeptide repeats 2. (472 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (590 aa)
DDX58DExD/H-box helicase 58. (954 aa)
MX2Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (555 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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