STRINGSTRING
FGF6 FGF6 FGF9 FGF9 FGF2 FGF2 CD163 CD163 FGF17 FGF17 ENSOCUP00000044284 ENSOCUP00000044284 FGF13 FGF13 TGFB2 TGFB2 FGF16 FGF16 FGF12 FGF12 FGF10 FGF10 CSF3 CSF3 TGFB3 TGFB3 FGF5 FGF5 FGF1 FGF1 IL21 IL21 EGF EGF G1TC56_RABIT G1TC56_RABIT FGF21 FGF21 PDGFC PDGFC CCL2 CCL2 FLT1 FLT1 FGF4 FGF4 IL6 IL6 CDH2 CDH2 INS INS IL1B IL1B THBS2 THBS2 VWF VWF VTN VTN LOC100358984 LOC100358984 HGF HGF LOC103345451 LOC103345451 FGF18 FGF18 ENSOCUP00000037329 ENSOCUP00000037329 FGF7 FGF7 IFNG IFNG FGF14 FGF14 HIF1A HIF1A KDR KDR FGF11 FGF11 CSF2 CSF2 CCN2 CCN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
CD163CD163 molecule. (1070 aa)
FGF17Uncharacterized protein; Belongs to the heparin-binding growth factors family. (151 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
CSF3Colony stimulating factor 3. (204 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1479 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (854 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
THBS2Thrombospondin 2. (1170 aa)
VWFVon Willebrand factor. (2788 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. (475 aa)
LOC100358984Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (857 aa)
HGFHeptapoietin A light chain; HPTA is an acidic heparin-binding growth factor for hepatocytes. (761 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
HIF1AUncharacterized protein. (851 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
CSF2Uncharacterized protein. (144 aa)
CCN2Cellular communication network factor 2. (437 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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