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CRBN | Cereblon. (491 aa) | ||||
CUL3 | Cullin 3; Belongs to the cullin family. (771 aa) | ||||
CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (1057 aa) | ||||
KLHDC3 | Kelch domain containing 3. (382 aa) | ||||
KLHDC10 | Kelch domain containing 10. (465 aa) | ||||
UBE2D2 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (317 aa) | ||||
CSF1 | Colony stimulating factor 1. (535 aa) | ||||
IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa) | ||||
NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) | ||||
PXDN | Peroxidasin. (1411 aa) | ||||
SKP1 | Uncharacterized protein; Belongs to the SKP1 family. (163 aa) | ||||
FEM1B | Fem-1 homolog B. (585 aa) | ||||
BRD3 | Bromodomain containing 3. (679 aa) | ||||
RBM39 | RNA binding motif protein 39 isoform a (Predicted). (530 aa) | ||||
ARIH2 | RBR-type E3 ubiquitin transferase. (493 aa) | ||||
UBE2M | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa) | ||||
ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa) | ||||
NFKBIA | NFKB inhibitor alpha. (314 aa) | ||||
CUL2 | Cullin 2; Belongs to the cullin family. (745 aa) | ||||
FEM1C | Fem-1 homolog C. (617 aa) | ||||
KCTD9 | Potassium channel tetramerization domain containing 9. (394 aa) | ||||
ARIH1 | RBR-type E3 ubiquitin transferase. (500 aa) | ||||
CUL5 | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa) | ||||
DCAF1 | DDB1 and CUL4 associated factor 1. (1507 aa) | ||||
ELOB | Elongin B. (118 aa) | ||||
IREB2 | Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (956 aa) | ||||
CUL4A | Cullin 4A; Belongs to the cullin family. (759 aa) | ||||
APPBP2 | Amyloid beta precursor protein binding protein 2. (585 aa) | ||||
KLHL12 | Kelch like family member 12. (851 aa) | ||||
BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (623 aa) | ||||
FBXW7 | F-box and WD repeat domain containing 7. (780 aa) | ||||
UBA1 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa) | ||||
VCP | Valosin containing protein; Belongs to the AAA ATPase family. (806 aa) | ||||
PXDNL | Peroxidasin like. (1467 aa) | ||||
BRD2 | Bromodomain containing 2. (802 aa) | ||||
NEDD8 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa) | ||||
CUL1 | Cullin 1; Belongs to the cullin family. (775 aa) | ||||
DDB1 | Damage specific DNA binding protein 1. (1140 aa) | ||||
GAN | Gigaxonin. (587 aa) | ||||
NAE1 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa) | ||||
IL13 | Interleukin 13. (138 aa) | ||||
KLHDC2 | Kelch domain containing 2. (406 aa) | ||||
GAPDH | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa) | ||||
KEAP1 | Kelch like ECH associated protein 1. (631 aa) | ||||
CTRL | Chymotrypsin like; Belongs to the peptidase S1 family. (249 aa) | ||||
CUL4B | Cullin 4B; Belongs to the cullin family. (901 aa) | ||||
UBE2D3 | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) | ||||
FBXL5 | F-box and leucine rich repeat protein 5. (726 aa) | ||||
CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) | ||||
UBE2F | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa) | ||||
ELOC | Elongin C; Belongs to the SKP1 family. (112 aa) |