STRINGSTRING
CRBN CRBN CUL3 CUL3 CHUK CHUK KLHDC3 KLHDC3 KLHDC10 KLHDC10 UBE2D2 UBE2D2 CSF1 CSF1 IL4 IL4 NFKB1 NFKB1 PXDN PXDN SKP1 SKP1 FEM1B FEM1B BRD3 BRD3 RBM39 RBM39 ARIH2 ARIH2 UBE2M UBE2M ALB ALB NFKBIA NFKBIA CUL2 CUL2 FEM1C FEM1C KCTD9 KCTD9 ARIH1 ARIH1 CUL5 CUL5 DCAF1 DCAF1 ELOB ELOB IREB2 IREB2 CUL4A CUL4A APPBP2 APPBP2 KLHL12 KLHL12 BTRC BTRC FBXW7 FBXW7 UBA1 UBA1 VCP VCP PXDNL PXDNL BRD2 BRD2 NEDD8 NEDD8 CUL1 CUL1 DDB1 DDB1 GAN GAN NAE1 NAE1 IL13 IL13 KLHDC2 KLHDC2 GAPDH GAPDH KEAP1 KEAP1 CTRL CTRL CUL4B CUL4B UBE2D3 UBE2D3 FBXL5 FBXL5 CDK2 CDK2 UBE2F UBE2F ELOC ELOC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRBNCereblon. (491 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
KLHDC3Kelch domain containing 3. (382 aa)
KLHDC10Kelch domain containing 10. (465 aa)
UBE2D2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (317 aa)
CSF1Colony stimulating factor 1. (535 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
PXDNPeroxidasin. (1411 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
FEM1BFem-1 homolog B. (585 aa)
BRD3Bromodomain containing 3. (679 aa)
RBM39RNA binding motif protein 39 isoform a (Predicted). (530 aa)
ARIH2RBR-type E3 ubiquitin transferase. (493 aa)
UBE2MUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (608 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
FEM1CFem-1 homolog C. (617 aa)
KCTD9Potassium channel tetramerization domain containing 9. (394 aa)
ARIH1RBR-type E3 ubiquitin transferase. (500 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1507 aa)
ELOBElongin B. (118 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (956 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
APPBP2Amyloid beta precursor protein binding protein 2. (585 aa)
KLHL12Kelch like family member 12. (851 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (623 aa)
FBXW7F-box and WD repeat domain containing 7. (780 aa)
UBA1Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
PXDNLPeroxidasin like. (1467 aa)
BRD2Bromodomain containing 2. (802 aa)
NEDD8NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
GANGigaxonin. (587 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
IL13Interleukin 13. (138 aa)
KLHDC2Kelch domain containing 2. (406 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
KEAP1Kelch like ECH associated protein 1. (631 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (249 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
FBXL5F-box and leucine rich repeat protein 5. (726 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
UBE2FUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa)
ELOCElongin C; Belongs to the SKP1 family. (112 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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