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EFCAB7 EFCAB7 MICU3 MICU3 MACF1 MACF1 CALM2 CALM2 LOC100344835 LOC100344835 ACTN2 ACTN2 ITSN1 ITSN1 KCNIP3 KCNIP3 LOC100349824 LOC100349824 CALU CALU LOC100357024 LOC100357024 DGKB DGKB SLC25A13 SLC25A13 RCN1 RCN1 ENSOCUP00000041847 ENSOCUP00000041847 ENSOCUP00000041558 ENSOCUP00000041558 DUOX2 DUOX2 CABP7 CABP7 ENSOCUP00000040484 ENSOCUP00000040484 EFCAB13 EFCAB13 ACTN1 ACTN1 KCNIP1 KCNIP1 PLCD4 PLCD4 GPD2 GPD2 NUCB2 NUCB2 MYL1 MYL1 RHOT1 RHOT1 CAPN9 CAPN9 CAPN3 CAPN3 ENSOCUP00000034581 ENSOCUP00000034581 CETN3 CETN3 DGKG DGKG CIB2 CIB2 NOX5 NOX5 CHP2 CHP2 MYL3 MYL3 EFHD2 EFHD2 MYL2 MYL2 SLC25A24 SLC25A24 PLCH1 PLCH1 CRACR2A CRACR2A EFHD1 EFHD1 FSTL1 FSTL1 SLC25A25 SLC25A25 LOC100344331 LOC100344331 EFCAB2 EFCAB2 RASGRP3 RASGRP3 MICU2 MICU2 FSTL4 FSTL4 G1U4L1_RABIT G1U4L1_RABIT ACTN3 ACTN3 LOC100344427 LOC100344427 CABP5 CABP5 VSNL1 VSNL1 FKBP7 FKBP7 GUCA1B GUCA1B CIB3 CIB3 PDCD6 PDCD6 MYL10 MYL10 G1TTB9_RABIT G1TTB9_RABIT PLS3 PLS3 DGKA DGKA FKBP9 FKBP9 ITSN2 ITSN2 KCNIP2 KCNIP2 CIB4 CIB4 HPCAL1 HPCAL1 HPCAL4 HPCAL4 CAPN2 CAPN2 CIB1 CIB1 MYLPF MYLPF LCP1 LCP1 PLS1 PLS1 CAPN11 CAPN11 GUCA1A GUCA1A CALB2 CALB2 RCVRN RCVRN EFCAB11 EFCAB11 SRI SRI PPEF2 PPEF2 MYL12A MYL12A DUOX1 DUOX1 SCGN SCGN DST DST CHP1 CHP1 EFHB EFHB HPCA HPCA CAPNS1 CAPNS1 CALML5 CALML5 SPTAN1 SPTAN1 SLC25A12 SLC25A12 CALM1 CALM1 CAPSL CAPSL EPS15L1 EPS15L1 NCALD NCALD USP32 USP32 CETN1 CETN1 CGREF1 CGREF1 CABP1 CABP1 CAPN8 CAPN8 TNNC1 TNNC1 CETN2 CETN2 LPCAT2 LPCAT2 CALB1 CALB1 NINL NINL PEF1 PEF1 EFCAB1 EFCAB1 EPS15 EPS15 CAPS2 CAPS2 RCN2 RCN2 CAPN1 CAPN1 GCA GCA RYR2 RYR2 KCNIP4 KCNIP4 RASEF RASEF NECAB1 NECAB1 CALN1 CALN1 MYL9 MYL9 FKBP10 FKBP10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFCAB7EF-hand calcium binding domain 7. (624 aa)
MICU3Mitochondrial calcium uptake family member 3. (534 aa)
MACF1Microtubule actin crosslinking factor 1. (7577 aa)
CALM2Uncharacterized protein; Belongs to the calmodulin family. (153 aa)
LOC100344835Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (474 aa)
ACTN2Actinin alpha 2. (893 aa)
ITSN1Intersectin 1. (1722 aa)
KCNIP3Potassium voltage-gated channel interacting protein 3. (263 aa)
LOC100349824Uncharacterized protein. (283 aa)
CALUCalumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). May modulate calcium release from the sarcoplasmic reticulum; Belongs to the CREC family. (358 aa)
LOC100357024Uncharacterized protein; Belongs to the parvalbumin family. (144 aa)
DGKBDiacylglycerol kinase. (803 aa)
SLC25A13Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (707 aa)
RCN1Uncharacterized protein. (376 aa)
ENSOCUP00000041847Uncharacterized protein; Belongs to the calmodulin family. (77 aa)
ENSOCUP00000041558Uncharacterized protein. (201 aa)
DUOX2Dual oxidase 2. (1545 aa)
CABP7Calcium binding protein 7. (218 aa)
ENSOCUP00000040484Uncharacterized protein. (222 aa)
EFCAB13EF-hand calcium binding domain 13. (788 aa)
ACTN1Actinin alpha 1. (1038 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (232 aa)
PLCD4Phosphoinositide phospholipase C. (789 aa)
GPD2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (827 aa)
NUCB2Nucleobindin 2. (476 aa)
MYL1Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (193 aa)
RHOT1Ras homolog family member T1. (797 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (690 aa)
CAPN3Uncharacterized protein; Belongs to the peptidase C2 family. (820 aa)
ENSOCUP00000034581Uncharacterized protein. (151 aa)
CETN3Centrin 3. (185 aa)
DGKGDiacylglycerol kinase. (807 aa)
CIB2Calcium and integrin binding family member 2. (245 aa)
NOX5NADPH oxidase 5. (1003 aa)
CHP2Calcineurin like EF-hand protein 2. (229 aa)
MYL3Myosin light chain 3. (327 aa)
EFHD2EF-hand domain family member D2. (158 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (232 aa)
SLC25A24Calcium-binding mitochondrial carrier protein SCaMC-1; Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitoc [...] (455 aa)
PLCH1Phosphoinositide phospholipase C. (1695 aa)
CRACR2ACalcium release activated channel regulator 2A. (779 aa)
EFHD1EF-hand domain family member D1. (238 aa)
FSTL1Follistatin like 1. (425 aa)
SLC25A25Solute carrier family 25 member 25; Belongs to the mitochondrial carrier (TC 2.A.29) family. (523 aa)
LOC100344331Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (466 aa)
EFCAB2EF-hand calcium binding domain 2. (159 aa)
RASGRP3RAS guanyl releasing protein 3. (691 aa)
MICU2Mitochondrial calcium uptake 2. (397 aa)
FSTL4Follistatin like 4. (807 aa)
G1U4L1_RABITUncharacterized protein. (195 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (900 aa)
LOC100344427Uncharacterized protein. (165 aa)
CABP5Calcium binding protein 5. (173 aa)
VSNL1Visinin like 1. (191 aa)
FKBP7Peptidylprolyl isomerase. (220 aa)
GUCA1BGuanylate cyclase activator 1B. (187 aa)
CIB3Calcium and integrin binding family member 3. (187 aa)
PDCD6Programmed cell death 6. (191 aa)
MYL10Myosin light chain 10. (167 aa)
G1TTB9_RABITUncharacterized protein. (200 aa)
PLS3Plastin 3. (630 aa)
DGKADiacylglycerol kinase. (734 aa)
FKBP9Peptidylprolyl isomerase. (572 aa)
ITSN2Intersectin 2. (1634 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (262 aa)
CIB4Calcium and integrin binding family member 4. (185 aa)
HPCAL1Hippocalcin like 1. (193 aa)
HPCAL4Hippocalcin like 4. (191 aa)
CAPN2Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. (832 aa)
CIB1Uncharacterized protein. (143 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform type 2. (200 aa)
LCP1Lymphocyte cytosolic protein 1. (636 aa)
PLS1Plastin 1. (630 aa)
CAPN11Calpain 11; Belongs to the peptidase C2 family. (715 aa)
GUCA1AUncharacterized protein. (275 aa)
CALB2Calbindin 2. (271 aa)
RCVRNRecoverin. (202 aa)
EFCAB11EF-hand calcium binding domain 11. (207 aa)
SRIUncharacterized protein. (422 aa)
PPEF2Serine/threonine-protein phosphatase with EF-hands. (752 aa)
MYL12AMyosin light chain 12A. (172 aa)
DUOX1Dual oxidase 1. (1586 aa)
SCGNSecretagogin, EF-hand calcium binding protein. (276 aa)
DSTDystonin. (5538 aa)
CHP1Calcineurin like EF-hand protein 1. (194 aa)
EFHBEF-hand domain family member B. (780 aa)
HPCAHippocalcin. (193 aa)
CAPNS1Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (266 aa)
CALML5Calmodulin like 5. (149 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2541 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (645 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
CAPSLCalcyphosine like. (208 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (833 aa)
NCALDNeurocalcin delta. (194 aa)
USP32Uncharacterized protein; Belongs to the peptidase C19 family. (1617 aa)
CETN1Centrin 1. (172 aa)
CGREF1Uncharacterized protein. (370 aa)
CABP1Uncharacterized protein. (227 aa)
CAPN8Calpain 8; Belongs to the peptidase C2 family. (731 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (161 aa)
CETN2Centrin 2. (172 aa)
LPCAT2Lysophosphatidylcholine acyltransferase 2. (542 aa)
CALB1Cerebellar calbindin. (261 aa)
NINLNinein like. (1315 aa)
PEF1Penta-EF-hand domain containing 1. (277 aa)
EFCAB1EF-hand calcium binding domain 1. (212 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (898 aa)
CAPS2Calcyphosine 2. (599 aa)
RCN2Reticulocalbin 2. (320 aa)
CAPN1Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (651 aa)
GCAUncharacterized protein. (215 aa)
RYR2Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] (4965 aa)
KCNIP4Potassium voltage-gated channel interacting protein 4. (275 aa)
RASEFRAS and EF-hand domain containing. (740 aa)
NECAB1N-terminal EF-hand calcium binding protein 1. (352 aa)
CALN1Calneuron 1. (262 aa)
MYL9Myosin light chain 9. (172 aa)
FKBP10Peptidylprolyl isomerase. (448 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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