node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARTN | GDF7 | ENSOCUP00000019801 | ENSOCUP00000018453 | Artemin. | Growth differentiation factor 7. | 0.408 |
ARTN | GDNF | ENSOCUP00000019801 | ENSOCUP00000002636 | Artemin. | Glial cell derived neurotrophic factor. | 0.500 |
ARTN | PSPN | ENSOCUP00000019801 | ENSOCUP00000005974 | Artemin. | Persephin. | 0.418 |
BMP10 | BMP4 | ENSOCUP00000008805 | ENSOCUP00000009545 | Bone morphogenetic protein 10. | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | 0.453 |
BMP10 | BMP5 | ENSOCUP00000008805 | ENSOCUP00000020293 | Bone morphogenetic protein 10. | Bone morphogenetic protein 5. | 0.479 |
BMP10 | BMP6 | ENSOCUP00000008805 | ENSOCUP00000002975 | Bone morphogenetic protein 10. | Bone morphogenetic protein 6. | 0.455 |
BMP10 | GDF2 | ENSOCUP00000008805 | ENSOCUP00000011724 | Bone morphogenetic protein 10. | Growth differentiation factor 2. | 0.728 |
BMP15 | GDF9 | ENSOCUP00000020965 | ENSOCUP00000011718 | TGF_BETA_2 domain-containing protein. | TGF_BETA_2 domain-containing protein. | 0.900 |
BMP15 | INHA | ENSOCUP00000020965 | ENSOCUP00000009768 | TGF_BETA_2 domain-containing protein. | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. | 0.644 |
BMP2 | BMP4 | ENSOCUP00000010036 | ENSOCUP00000009545 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | 0.955 |
BMP2 | BMP5 | ENSOCUP00000010036 | ENSOCUP00000020293 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. | Bone morphogenetic protein 5. | 0.587 |
BMP2 | BMP6 | ENSOCUP00000010036 | ENSOCUP00000002975 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. | Bone morphogenetic protein 6. | 0.632 |
BMP2 | BMP7 | ENSOCUP00000010036 | ENSOCUP00000022037 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. | TGF_BETA_2 domain-containing protein. | 0.949 |
BMP2 | GDF5 | ENSOCUP00000010036 | ENSOCUP00000009138 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. | Growth differentiation factor 5 preproprotein (Predicted). | 0.616 |
BMP4 | BMP10 | ENSOCUP00000009545 | ENSOCUP00000008805 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Bone morphogenetic protein 10. | 0.453 |
BMP4 | BMP2 | ENSOCUP00000009545 | ENSOCUP00000010036 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. | 0.955 |
BMP4 | BMP5 | ENSOCUP00000009545 | ENSOCUP00000020293 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Bone morphogenetic protein 5. | 0.650 |
BMP4 | BMP6 | ENSOCUP00000009545 | ENSOCUP00000002975 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Bone morphogenetic protein 6. | 0.660 |
BMP4 | BMP7 | ENSOCUP00000009545 | ENSOCUP00000022037 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | TGF_BETA_2 domain-containing protein. | 0.922 |
BMP4 | GDF5 | ENSOCUP00000009545 | ENSOCUP00000009138 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Growth differentiation factor 5 preproprotein (Predicted). | 0.530 |