STRINGSTRING
NCOA1 NCOA1 AHR AHR HES2 HES2 USF1 USF1 MXI1 MXI1 NHLH1 NHLH1 NEUROD1 NEUROD1 EBF2 EBF2 USF3 USF3 BHLHE41 BHLHE41 HEY2 HEY2 ID1 ID1 LMAN2 LMAN2 NEUROD4 NEUROD4 ATOH7 ATOH7 NCOA3 NCOA3 ARNT ARNT TCF4 TCF4 TFAP4 TFAP4 ENSOCUP00000030497 ENSOCUP00000030497 TAL2 TAL2 TCF24 TCF24 ARNTL2 ARNTL2 HIF1A HIF1A G1U6L7_RABIT G1U6L7_RABIT MYOD1 MYOD1 CLOCK CLOCK HES3 HES3 OLIG1 OLIG1 NEUROG2 NEUROG2 ARNT2 ARNT2 MYF5 MYF5 BHLHA15 BHLHA15 MYCL MYCL LOC100358544 LOC100358544 HES1 HES1 EPAS1 EPAS1 OLIG3 OLIG3 SREBF2 SREBF2 ID3 ID3 BHLHE22 BHLHE22 MXD4 MXD4 TFEB TFEB G1TN85_RABIT G1TN85_RABIT USF2 USF2 EBF4 EBF4 TCF15 TCF15 NPAS3 NPAS3 NPAS2 NPAS2 TWIST2 TWIST2 SOHLH2 SOHLH2 TCF12 TCF12 TCF21 TCF21 FIGLA FIGLA TAL1 TAL1 HEY1 HEY1 HAND2 HAND2 MNT MNT MXD1 MXD1 TFE3 TFE3 MLX MLX G1T8W2_RABIT G1T8W2_RABIT MAX MAX MYC MYC ATOH1 ATOH1 SIM2 SIM2 MYOG MYOG ASCL3 ASCL3 MLXIP MLXIP HAND1 HAND1 HELT HELT EBF1 EBF1 EBF3 EBF3 TCF23 TCF23 MSC MSC MGA MGA TFEC TFEC NCOA2 NCOA2 ARNTL ARNTL ATOH8 ATOH8 SIM1 SIM1 MITF MITF BHLHA9 BHLHA9 MYF6 MYF6 NPAS4 NPAS4 HEYL HEYL MSGN1 MSGN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCOA1Nuclear receptor coactivator. (1440 aa)
AHRAryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] (887 aa)
HES2Uncharacterized protein. (274 aa)
USF1Upstream stimulatory factor 1; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. Regulates the expression of the surfactant protein- A (SP-A) gene. (326 aa)
MXI1MAX interactor 1, dimerization protein. (237 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
NEUROD1BHLH domain-containing protein. (203 aa)
EBF2EBF transcription factor 2. (609 aa)
USF3Upstream transcription factor family member 3. (2239 aa)
BHLHE41BHLH domain-containing protein. (122 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
LMAN2Lectin, mannose binding 2. (486 aa)
NEUROD4Neurogenic differentiation factor. (357 aa)
ATOH7Atonal bHLH transcription factor 7. (152 aa)
NCOA3Nuclear receptor coactivator. (1444 aa)
ARNTAryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...] (739 aa)
TCF4Transcription factor 4. (701 aa)
TFAP4Transcription factor AP-4. (585 aa)
ENSOCUP00000030497BHLH domain-containing protein. (257 aa)
TAL2TAL bHLH transcription factor 2. (142 aa)
TCF24Transcription factor 24. (167 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (593 aa)
HIF1AUncharacterized protein. (851 aa)
G1U6L7_RABITBHLH domain-containing protein. (316 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (323 aa)
CLOCKClock circadian regulator. (853 aa)
HES3BHLH domain-containing protein. (170 aa)
OLIG1Oligodendrocyte transcription factor 1. (261 aa)
NEUROG2Neurogenin 2. (274 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (668 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
BHLHA15Basic helix-loop-helix family member a15. (207 aa)
MYCLMYCL proto-oncogene, bHLH transcription factor. (396 aa)
LOC100358544Uncharacterized protein. (1025 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
EPAS1Endothelial PAS domain protein 1. (902 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1137 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
BHLHE22Basic helix-loop-helix family member e22. (403 aa)
MXD4MAX dimerization protein 4. (208 aa)
TFEBBHLH domain-containing protein. (485 aa)
G1TN85_RABITUncharacterized protein. (225 aa)
USF2Upstream transcription factor 2, c-fos interacting. (317 aa)
EBF4EBF family member 4. (572 aa)
TCF15Transcription factor 15. (199 aa)
NPAS3Neuronal PAS domain protein 3. (921 aa)
NPAS2Neuronal PAS domain protein 2. (760 aa)
TWIST2Twist family bHLH transcription factor 2. (160 aa)
SOHLH2BHLH domain-containing protein. (421 aa)
TCF12Transcription factor 12. (675 aa)
TCF21Transcription factor 21. (179 aa)
FIGLAFolliculogenesis specific bHLH transcription factor. (208 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (319 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (452 aa)
HAND2BHLH domain-containing protein. (426 aa)
MNTMAX network transcriptional repressor. (587 aa)
MXD1MAX dimerization protein 1. (221 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (569 aa)
MLXMAX dimerization protein MLX. (335 aa)
G1T8W2_RABITBHLH domain-containing protein. (398 aa)
MAXMYC associated factor X. (160 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
ATOH1Atonal bHLH transcription factor 1. (359 aa)
SIM2SIM bHLH transcription factor 2. (611 aa)
MYOGMyogenin. (225 aa)
ASCL3Achaete-scute family bHLH transcription factor 3. (181 aa)
MLXIPMLX interacting protein. (925 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (215 aa)
HELTHelt bHLH transcription factor. (242 aa)
EBF1EBF transcription factor 1. (591 aa)
EBF3EBF transcription factor 3. (520 aa)
TCF23BHLH domain-containing protein. (377 aa)
MSCMusculin. (200 aa)
MGAMAX dimerization protein MGA. (3033 aa)
TFECTranscription factor EC. (389 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (625 aa)
ATOH8Atonal bHLH transcription factor 8. (369 aa)
SIM1SIM bHLH transcription factor 1. (766 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
BHLHA9Basic helix-loop-helix family member a9. (238 aa)
MYF6Myogenic factor 6. (242 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (301 aa)
MSGN1Mesogenin 1. (193 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (24%) [HD]