(45 nodes) Glycerolipid metabolism network (Oryctolagus cuniculus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	DGKG	Diacylglycerol kinase. (807 aa)
	LIPC	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity). (544 aa)
	TKFC	Triokinase and FMN cyclase. (578 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (456 aa)
	LPIN1	Lipin 1. (1106 aa)
	AGPAT1	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
	MOGAT1	Monoacylglycerol O-acyltransferase 1. (369 aa)
	GLYCTK	Glycerate kinase. (523 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (844 aa)
	PNLIPRP1	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (473 aa)
	AGPAT5	Acyltransf_C domain-containing protein. (197 aa)
	LPIN2	Lipin 2. (935 aa)
	GLA	Alpha-galactosidase. (425 aa)
	LPIN3	Lipin 3. (871 aa)
	LIPF	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (401 aa)
	DGKE	Diacylglycerol kinase. (567 aa)
	MOGAT2	Monoacylglycerol O-acyltransferase 2. (334 aa)
	G1TAW2_RABIT	Uncharacterized protein. (310 aa)
	MBOAT2	Membrane bound O-acyltransferase domain containing 2; Belongs to the membrane-bound acyltransferase family. (500 aa)
	AGK	Acylglycerol kinase. (257 aa)
	G1THC3_RABIT	PNPLA domain-containing protein. (443 aa)
	DGKA	Diacylglycerol kinase. (734 aa)
	DGKK	Diacylglycerol kinase. (1230 aa)
	AKR1B10	Aldo_ket_red domain-containing protein. (365 aa)
	PLPP2	Phospholipid phosphatase 2. (269 aa)
	DGKI	Diacylglycerol kinase. (914 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (497 aa)
	AKR1B1	Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. (333 aa)
	PLPP4	acidPPc domain-containing protein. (457 aa)
	ENSOCUP00000032685	Uncharacterized protein. (308 aa)
	ALDH9A1	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (474 aa)
	MGLL	Uncharacterized protein. (190 aa)
	ENSOCUP00000037325	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (156 aa)
	LOC100340546	Uncharacterized protein. (448 aa)
	ALDH3A2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (507 aa)
	GK	Uncharacterized protein; Belongs to the FGGY kinase family. (602 aa)
	LOC103345697	Uncharacterized protein. (361 aa)
	ALDH2	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (671 aa)
	DGKB	Diacylglycerol kinase. (803 aa)
	PLPP3	acidPPc domain-containing protein. (331 aa)
	ALDH7A1	Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (685 aa)
	MBOAT1	Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family. (511 aa)
	DGKH	Diacylglycerol kinase. (1257 aa)
	GPAT3	Glycerol-3-phosphate acyltransferase 3. (607 aa)
	PNLIPRP2	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family. (547 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGK	AGPAT1	ENSOCUP00000015071	ENSOCUP00000004772	Acylglycerol kinase.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.909
AGK	AGPAT5	ENSOCUP00000015071	ENSOCUP00000008132	Acylglycerol kinase.	Acyltransf_C domain-containing protein.	0.908
AGK	ENSOCUP00000032685	ENSOCUP00000015071	ENSOCUP00000032685	Acylglycerol kinase.	Uncharacterized protein.	0.900
AGK	ENSOCUP00000037325	ENSOCUP00000015071	ENSOCUP00000037325	Acylglycerol kinase.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.901
AGK	G1TAW2_RABIT	ENSOCUP00000015071	ENSOCUP00000013832	Acylglycerol kinase.	Uncharacterized protein.	0.900
AGK	G1THC3_RABIT	ENSOCUP00000015071	ENSOCUP00000016329	Acylglycerol kinase.	PNPLA domain-containing protein.	0.900
AGK	GPAM	ENSOCUP00000015071	ENSOCUP00000006821	Acylglycerol kinase.	Glycerol-3-phosphate acyltransferase 1, mitochondrial.	0.911
AGK	GPAT3	ENSOCUP00000015071	ENSOCUP00000048261	Acylglycerol kinase.	Glycerol-3-phosphate acyltransferase 3.	0.912
AGK	GPAT4	ENSOCUP00000015071	ENSOCUP00000001787	Acylglycerol kinase.	Glycerol-3-phosphate acyltransferase 4.	0.916
AGK	LIPC	ENSOCUP00000015071	ENSOCUP00000001411	Acylglycerol kinase.	Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity).	0.901
AGK	LIPF	ENSOCUP00000015071	ENSOCUP00000010744	Acylglycerol kinase.	Lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.904
AGK	LOC100340546	ENSOCUP00000015071	ENSOCUP00000038244	Acylglycerol kinase.	Uncharacterized protein.	0.900
AGK	LOC103345697	ENSOCUP00000015071	ENSOCUP00000042037	Acylglycerol kinase.	Uncharacterized protein.	0.900
AGK	MBOAT1	ENSOCUP00000015071	ENSOCUP00000045343	Acylglycerol kinase.	Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family.	0.900
AGK	MBOAT2	ENSOCUP00000015071	ENSOCUP00000014593	Acylglycerol kinase.	Membrane bound O-acyltransferase domain containing 2; Belongs to the membrane-bound acyltransferase family.	0.901
AGK	MGLL	ENSOCUP00000015071	ENSOCUP00000034747	Acylglycerol kinase.	Uncharacterized protein.	0.913
AGK	MOGAT1	ENSOCUP00000015071	ENSOCUP00000005051	Acylglycerol kinase.	Monoacylglycerol O-acyltransferase 1.	0.900
AGK	MOGAT2	ENSOCUP00000015071	ENSOCUP00000012217	Acylglycerol kinase.	Monoacylglycerol O-acyltransferase 2.	0.900
AGK	PNLIPRP1	ENSOCUP00000015071	ENSOCUP00000007072	Acylglycerol kinase.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.901
AGK	PNLIPRP2	ENSOCUP00000015071	ENSOCUP00000048398	Acylglycerol kinase.	Triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family.	0.901