STRINGSTRING
LOC100340625 LOC100340625 TP53 TP53 ABCB11 ABCB11 ADCY8 ADCY8 JAG1 JAG1 ADCY4 ADCY4 ADCY7 ADCY7 ESR1 ESR1 PIK3CB PIK3CB ESR2 ESR2 PIK3R1 PIK3R1 SOS2 SOS2 BAX BAX SHC4 SHC4 DLL3 DLL3 ADCY9 ADCY9 CDKN2C CDKN2C ADCY2 ADCY2 SLC35E3 SLC35E3 NCOR1 NCOR1 EGFR EGFR ERBB2 ERBB2 MAPK10 MAPK10 DLL4 DLL4 KRAS KRAS CDK4 CDK4 MTOR MTOR MAPK1 MAPK1 MAPK3 MAPK3 CDKN1B CDKN1B LOC100345250 LOC100345250 E2F3 E2F3 ADCY5 ADCY5 ADCY3 ADCY3 CDKN1A CDKN1A SHC1 SHC1 ARAF ARAF NOTCH4 NOTCH4 LOC100346323 LOC100346323 GPER1 GPER1 MAPK8 MAPK8 NRAS NRAS SOS1 SOS1 PIK3CD PIK3CD MED1 MED1 IGF1 IGF1 FOS FOS MMP9 MMP9 PIK3CA PIK3CA MAP2K1 MAP2K1 MAPK9 MAPK9 MAPK12 MAPK12 E2F2 E2F2 NOTCH2 NOTCH2 BCL2 BCL2 LOC100352221 LOC100352221 RAF1 RAF1 SP1 SP1 NCOA3 NCOA3 PTK2-2 PTK2-2 JUN JUN ADCY6 ADCY6 RB1 RB1 AKT3 AKT3 DLL1 DLL1 GRB2 GRB2 PRKACB PRKACB MAPK13 MAPK13 GNAS GNAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100340625ANK_REP_REGION domain-containing protein. (324 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
ABCB11Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts. (1325 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ESR2Estrogen receptor 2. (523 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
SHC4SHC adaptor protein 4. (630 aa)
DLL3Delta like canonical Notch ligand 3. (605 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1236 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1040 aa)
SLC35E3Uncharacterized protein. (767 aa)
NCOR1Nuclear receptor corepressor 1. (2374 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LOC100345250Uncharacterized protein. (461 aa)
E2F3E2F transcription factor 3. (462 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1010 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
CDKN1AUncharacterized protein. (231 aa)
SHC1SHC adaptor protein 1. (474 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
NOTCH4Uncharacterized protein. (1854 aa)
LOC100346323Uncharacterized protein. (240 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
E2F2E2F transcription factor 2. (440 aa)
NOTCH2Notch receptor 2. (2481 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
LOC100352221CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (463 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
SP1Sp1 transcription factor. (792 aa)
NCOA3Nuclear receptor coactivator. (1444 aa)
PTK2-2FERM_N_2 domain-containing protein. (121 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
RB1RB transcriptional corepressor 1. (943 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
GNASGNAS complex locus. (977 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.