STRINGSTRING
MAPK8IP2 MAPK8IP2 DUSP2 DUSP2 PDGFRA PDGFRA RASGRP4 RASGRP4 FGF2 FGF2 FGF9 FGF9 CACNG6 CACNG6 CRKL CRKL FLNA FLNA TP53 TP53 LAMTOR3 LAMTOR3 RASA2 RASA2 GNA12 GNA12 DUSP5 DUSP5 MAP3K7 MAP3K7 PDGFRB PDGFRB FGF6 FGF6 DUSP7 DUSP7 MAP3K2 MAP3K2 RPS6KA2 RPS6KA2 SRF SRF DUSP6 DUSP6 STK4 STK4 MET MET DUSP4 DUSP4 FGF19 FGF19 CACNG3 CACNG3 CD14 CD14 EFNA1 EFNA1 ECSIT ECSIT STK3 STK3 RASA1 RASA1 FLT3 FLT3 MAP3K13 MAP3K13 KDR KDR CACNA1F CACNA1F TGFB2 TGFB2 MAPKAPK3 MAPKAPK3 PPM1B PPM1B PDGFA PDGFA MRAS MRAS SOS2 SOS2 MAP3K8 MAP3K8 NFATC1 NFATC1 TNF TNF IL1R1 IL1R1 IKBKB IKBKB CACNA2D4 CACNA2D4 CACNB3 CACNB3 DUSP10 DUSP10 FGF16 FGF16 MAP2K6 MAP2K6 NLK NLK DUSP1 DUSP1 PAK2 PAK2 PTPN7 PTPN7 FGF10 FGF10 NF1 NF1 IL1A IL1A RPS6KA5 RPS6KA5 GADD45A GADD45A RAPGEF2 RAPGEF2 NTRK2 NTRK2 RAC1 RAC1 NFATC3 NFATC3 EGFR EGFR DAXX DAXX ERBB2 ERBB2 DUSP16 DUSP16 MAPK10 MAPK10 NTRK1 NTRK1 FLT4 FLT4 TGFB3 TGFB3 VEGFA VEGFA HSPA2 HSPA2 NR4A1 NR4A1 PLA2G4B PLA2G4B PTPRR PTPRR KRAS KRAS ATF2 ATF2 TAB2 TAB2 FGF5 FGF5 CACNA2D3 CACNA2D3 HSPB1 HSPB1 CACNA1B CACNA1B MAP3K11 MAP3K11 GADD45G GADD45G CACNA1D CACNA1D MAPK1 MAPK1 MAPK3 MAPK3 FGF1 FGF1 PLA2G4D PLA2G4D CACNG4 CACNG4 MAPKAPK2 MAPKAPK2 MYC MYC ELK4 ELK4 PLA2G4A PLA2G4A PLA2G4C PLA2G4C MAP3K20 MAP3K20 MAPK7 MAPK7 PDGFD PDGFD ANGPT2 ANGPT2 MAP3K5 MAP3K5 TAOK1 TAOK1 EFNA5 EFNA5 EREG EREG AREG AREG EGF EGF ARAF ARAF G1TC56_RABIT G1TC56_RABIT MAP4K3 MAP4K3 MAP3K4 MAP3K4 FGF21 FGF21 PDGFC PDGFC ERBB3 ERBB3 VEGFD VEGFD VEGFC VEGFC TAB1 TAB1 EPHA2 EPHA2 DDIT3 DDIT3 GNG14 GNG14 FLT1 FLT1 FGF4 FGF4 MAP2K7 MAP2K7 TRADD TRADD MAPK8 MAPK8 RASGRP2 RASGRP2 NRAS NRAS SOS1 SOS1 PPP3CB PPP3CB NTF4 NTF4 PGF PGF INS INS GNG12 GNG12 IGF1 IGF1 FOS FOS CACNA2D2 CACNA2D2 CACNG2 CACNG2 IL1B IL1B DUSP9 DUSP9 ANGPT4 ANGPT4 G1U0I3_RABIT G1U0I3_RABIT B7NZQ1_RABIT B7NZQ1_RABIT NFKB1 NFKB1 CACNA1S CACNA1S FGF23 FGF23 CACNG7 CACNG7 RASGRF1 RASGRF1 CSF1 CSF1 CDC42-2 CDC42-2 NTF3 NTF3 RASGRP3 RASGRP3 TRAF6 TRAF6 LOC100358984 LOC100358984 PDGFB PDGFB PPP3CC PPP3CC MECOM MECOM MAP2K1 MAP2K1 HSPA8 HSPA8 RASGRF2 RASGRF2 IRAK1 IRAK1 MAPT MAPT HGF HGF MAPK9 MAPK9 CHUK CHUK IRAK4 IRAK4 LOC103345451 LOC103345451 PLA2G4E PLA2G4E MAPKAPK5 MAPKAPK5 FLNB FLNB KITLG KITLG FGF18 FGF18 FAS FAS FGFR2 FGFR2 MAPK12 MAPK12 MYD88 MYD88 PLA2G4F PLA2G4F RRAS2 RRAS2 KIT KIT MAP2K4 MAP2K4 TGFA TGFA TGFBR1 TGFBR1 ERBB4 ERBB4 MAP3K1 MAP3K1 DUSP3 DUSP3 RAF1 RAF1 CASP3 CASP3 PAK1 PAK1 BDNF BDNF MAP4K4 MAP4K4 RASGRP1 RASGRP1 MAP3K3 MAP3K3 ENSOCUP00000037329 ENSOCUP00000037329 MAP2K5 MAP2K5 FGF7 FGF7 EFNA4 EFNA4 FGFR4 FGFR4 RPS6KA3 RPS6KA3 JUN JUN CACNB2 CACNB2 HSPA1L HSPA1L RPS6KA1 RPS6KA1 RAP1A RAP1A AKT3 AKT3 RAP1B RAP1B FGF17 FGF17 FGFR1 FGFR1 ELK1 ELK1 INSR INSR EFNA3 EFNA3 GRB2 GRB2 MKNK1 MKNK1 CACNB1 CACNB1 CACNA2D1 CACNA2D1 IL1RAP IL1RAP PRKACB PRKACB ENSOCUP00000044284 ENSOCUP00000044284 MAP3K6 MAP3K6 PPM1A PPM1A PPP3CA PPP3CA IKBKG IKBKG TNFRSF1A TNFRSF1A PRKCB PRKCB MAP3K12 MAP3K12 TAOK3 TAOK3 FLNC FLNC MAPK13 MAPK13 PTPN5 PTPN5 ANGPT1 ANGPT1 LOC100341883 LOC100341883 CACNA1G CACNA1G
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
MAPK8IP2Uncharacterized protein. (558 aa)
DUSP2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (314 aa)
PDGFRAProtein kinase domain-containing protein. (773 aa)
RASGRP4RAS guanyl releasing protein 4. (668 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (254 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
FLNAUncharacterized protein. (2617 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (124 aa)
RASA2RAS p21 protein activator 2. (859 aa)
GNA12G protein subunit alpha 12. (457 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DUSP7Uncharacterized protein. (358 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (623 aa)
RPS6KA2Non-specific serine/threonine protein kinase. (687 aa)
SRFSerum response factor. (685 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
STK4Uncharacterized protein. (487 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (386 aa)
FGF19Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (218 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (314 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
ECSITECSIT signalling integrator. (431 aa)
STK3Serine/threonine kinase 3. (491 aa)
RASA1RAS p21 protein activator 1. (967 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (1009 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CACNA1FCalcium voltage-gated channel subunit alpha1 F. (1734 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
PPM1BPPM-type phosphatase domain-containing protein. (479 aa)
PDGFAPlatelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] (150 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (474 aa)
NFATC1RHD domain-containing protein. (672 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IL1R1Interleukin 1 receptor type 1. (699 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
CACNA2D4VWFA domain-containing protein. (557 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). (550 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
PAK2Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...] (524 aa)
PTPN7Uncharacterized protein. (112 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
NF1Neurofibromin 1. (2841 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1659 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
RAC1Rac family small GTPase 1. (199 aa)
NFATC3Nuclear factor of activated T cells 3. (1070 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
DAXXDeath domain associated protein. (740 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
DUSP16Dual specificity phosphatase 16. (440 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NTRK1Tyrosine-protein kinase receptor. (823 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (635 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (784 aa)
PLA2G4BPhospholipase A2. (779 aa)
PTPRRProtein tyrosine phosphatase receptor type R. (657 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1012 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (204 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha-1B; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin- GVIA (AC P01522) (By similarity). They are however insen [...] (2197 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (839 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (149 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2141 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PLA2G4DPhospholipase A2. (825 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (341 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] (379 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
ELK4ETS transcription factor ELK4. (433 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (748 aa)
PLA2G4CPLA2c domain-containing protein. (829 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (875 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (818 aa)
PDGFDPlatelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). (538 aa)
ANGPT2Angiopoietin 2. (496 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1316 aa)
TAOK1TAO kinase 1. (1001 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
EREGEpiregulin. (169 aa)
AREGAmphiregulin. (275 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (875 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1496 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
EPHA2EPH receptor A2. (1031 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1479 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
TRADDTNFRSF1A associated via death domain. (447 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
RASGRP2Uncharacterized protein. (296 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
PPP3CBSerine/threonine-protein phosphatase. (518 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (205 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (984 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (256 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (465 aa)
ANGPT4Angiopoietin 4. (487 aa)
G1U0I3_RABITRhodanese domain-containing protein. (196 aa)
B7NZQ1_RABITFLNA protein (Predicted). (780 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. (1828 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (274 aa)
RASGRF1Ras protein specific guanine nucleotide releasing factor 1. (1139 aa)
CSF1Colony stimulating factor 1. (535 aa)
CDC42-2Uncharacterized protein. (222 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
RASGRP3RAS guanyl releasing protein 3. (691 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
LOC100358984Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (857 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
PPP3CCSerine/threonine-protein phosphatase. (574 aa)
MECOMMDS1 and EVI1 complex locus. (1226 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
HSPA8Uncharacterized protein. (917 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1181 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
MAPTMicrotubule-associated protein. (840 aa)
HGFHeptapoietin A light chain; HPTA is an acidic heparin-binding growth factor for hepatocytes. (761 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (464 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
PLA2G4EPhospholipase A2. (854 aa)
MAPKAPK5MAPK activated protein kinase 5. (537 aa)
FLNBFilamin-B; Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). (2695 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
FASUncharacterized protein. (484 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
MYD88Uncharacterized protein. (476 aa)
PLA2G4FPhospholipase A2. (897 aa)
RRAS2RAS related 2. (225 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (520 aa)
TGFATransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar (By similarity). Inhibitor of acid secretion. Inhibitor of aminopyrine uptake in parietal cells (in vitro). (185 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1408 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (170 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
PAK1Non-specific serine/threonine protein kinase. (585 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (265 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4. (1323 aa)
RASGRP1RAS guanyl releasing protein 1. (798 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (681 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
MAP2K5Mitogen-activated protein kinase kinase 5. (551 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
EFNA4Ephrin A4; Belongs to the ephrin family. (204 aa)
FGFR4Fibroblast growth factor receptor. (862 aa)
RPS6KA3Ribosomal protein S6 kinase. (751 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. (632 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like. (414 aa)
RPS6KA1Ribosomal protein S6 kinase. (813 aa)
RAP1AUncharacterized protein. (184 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
RAP1BUncharacterized protein. (184 aa)
FGF17Uncharacterized protein; Belongs to the heparin-binding growth factors family. (151 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
ELK1ETS transcription factor ELK1. (512 aa)
INSRTyrosine-protein kinase receptor. (1377 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (330 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (427 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1; Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By similarity). (642 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation- contraction coupling. (1061 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1300 aa)
PPM1AProtein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). (385 aa)
PPP3CASerine/threonine-protein phosphatase. (695 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
PRKCBProtein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
TAOK3Protein kinase domain-containing protein. (473 aa)
FLNCFilamin C. (2628 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (539 aa)
ANGPT1Angiopoietin 1. (551 aa)
LOC100341883Protein kinase domain-containing protein. (262 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2257 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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