STRINGSTRING
ATP1A4 ATP1A4 LIPE LIPE GRIA3 GRIA3 ATP1B3 ATP1B3 VIP VIP MYL9 MYL9 GNAI1 GNAI1 EDN2 EDN2 EDNRA EDNRA TSHR TSHR PDE4A PDE4A PLCE1 PLCE1 ADCY10 ADCY10 RYR2 RYR2 ADCY8 ADCY8 ADCY4 ADCY4 PTCH1 PTCH1 ATP1B2 ATP1B2 ADCY7 ADCY7 VIPR2 VIPR2 ATP1B4 ATP1B4 GIP GIP CREBBP CREBBP DRD1 DRD1 PIK3CB PIK3CB PIK3R1 PIK3R1 CACNA1F CACNA1F CREB1 CREB1 GNAI3 GNAI3 CNGA1 CNGA1 NFATC1 NFATC1 ATP2B4 ATP2B4 GLI3 GLI3 LOC100348238 LOC100348238 NPPA NPPA GHSR GHSR PDE3A PDE3A SST SST PDE3B PDE3B ADCY9 ADCY9 CGA CGA ADCY2 ADCY2 ADORA2A ADORA2A PPP1CC PPP1CC ARAP3 ARAP3 SSTR2 SSTR2 CNGA2 CNGA2 ADCYAP1 ADCYAP1 HTR1A HTR1A RAC1 RAC1 NPY1R NPY1R MAPK10 MAPK10 NPY NPY ADORA1 ADORA1 HTR1D HTR1D FSHR FSHR EP300 EP300 CALM1 CALM1 CREB3L4 CREB3L4 GPR119 GPR119 PTGER2 PTGER2 CALML5 CALML5 RHOA RHOA EDN1 EDN1 CACNA1D CACNA1D MAPK1 MAPK1 MAPK3 MAPK3 PLN PLN PLD1 PLD1 LOC100345250 LOC100345250 ABCC4 ABCC4 RAPGEF4 RAPGEF4 GRIN2B GRIN2B ADCY5 ADCY5 ADCY3 ADCY3 NFKBIA NFKBIA ADRB2 ADRB2 GABBR2 GABBR2 TIAM1 TIAM1 CHRM2 CHRM2 FFAR2 FFAR2 CAMK2A CAMK2A CNGB3 CNGB3 HCN4 HCN4 LOC100346323 LOC100346323 SUCNR1 SUCNR1 LOC100356250 LOC100356250 GRIA2 GRIA2 LOC100346856 LOC100346856 HTR1B HTR1B FSHB FSHB HCAR1 HCAR1 ORAI1 ORAI1 Tshb Tshb SSTR1 SSTR1 MAPK8 MAPK8 HTR1F HTR1F CAMK4 CAMK4 GNAI2 GNAI2 GCG GCG F2R F2R LOC100348967 LOC100348967 PIK3CD PIK3CD GLI1 GLI1 FOS FOS GRIN2C GRIN2C NPR1 NPR1 MC2R MC2R FXYD1 FXYD1 SLC9A1 SLC9A1 GRIN3A GRIN3A NFKB1 NFKB1 CACNA1S CACNA1S PPP1CA PPP1CA RAPGEF3 RAPGEF3 ATP1A1 ATP1A1 PPP1R1B PPP1R1B DRD5 DRD5 LHB LHB ATP1A2 ATP1A2 HCAR2 HCAR2 PIK3CA PIK3CA CNGA4 CNGA4 CNGB1 CNGB1 LHCGR LHCGR CNGA3 CNGA3 MAP2K1 MAP2K1 PDE4B PDE4B GHRL GHRL MAPK9 MAPK9 PDE10A PDE10A PDE4D PDE4D CREB3 CREB3 ROCK1 ROCK1 CFTR CFTR RRAS2 RRAS2 CREB5 CREB5 ATP2A3 ATP2A3 GRIN2A GRIN2A VAV3 VAV3 RAF1 RAF1 PAK1 PAK1 BDNF BDNF POMC POMC ATP2A2 ATP2A2 ATP1B1 ATP1B1 GRIA1 GRIA1 JUN JUN CREB3L2 CREB3L2 ADCY6 ADCY6 RAP1A RAP1A AKT3 AKT3 RAP1B RAP1B HTR1E HTR1E GRIA4 GRIA4 ACOX1 ACOX1 PRKACB PRKACB ATP1A3 ATP1A3 LOC100356734 LOC100356734 OXT OXT PPP1CB PPP1CB EDN3 EDN3 PTGER3 PTGER3 LOC103349229 LOC103349229 HTR4 HTR4 GABBR1 GABBR1 HHIP HHIP GNAS GNAS ATP2B3 ATP2B3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
LIPELipase E, hormone sensitive type. (1082 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (274 aa)
VIPVasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (166 aa)
MYL9Myosin light chain 9. (172 aa)
GNAI1G protein subunit alpha i1. (349 aa)
EDN2Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. (360 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
PDE4APhosphodiesterase. (700 aa)
PLCE1Phosphoinositide phospholipase C. (2300 aa)
ADCY10Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1626 aa)
RYR2Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] (4965 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
PTCH1Patched 1. (1321 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). (290 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (439 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (352 aa)
GIPGastric inhibitory polypeptide. (153 aa)
CREBBPCREB binding protein. (2403 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (448 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CACNA1FCalcium voltage-gated channel subunit alpha1 F. (1734 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (693 aa)
NFATC1RHD domain-containing protein. (672 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
GLI3GLI family zinc finger 3. (1575 aa)
LOC100348238Uncharacterized protein. (1149 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (153 aa)
GHSRGrowth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine) (By similarity). (366 aa)
PDE3APhosphodiesterase. (1128 aa)
SSTSomatostatin. (116 aa)
PDE3BPhosphodiesterase. (1117 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1236 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (120 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1040 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
PPP1CCSerine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (337 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3. (1499 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CNGA2Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily. (696 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
HTR1AG_PROTEIN_RECEP_F1_2 domain-containing protein. (422 aa)
RAC1Rac family small GTPase 1. (199 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NPYNeuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (97 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (328 aa)
HTR1D5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] (377 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (703 aa)
EP300E1A binding protein p300. (2418 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (336 aa)
PTGER2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
CALML5Calmodulin like 5. (149 aa)
RHOARas homolog family member A. (193 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2141 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). (52 aa)
PLD1Phospholipase. (1031 aa)
LOC100345250Uncharacterized protein. (461 aa)
ABCC4ATP binding cassette subfamily C member 4. (1325 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1011 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1010 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ADRB2Adrenoceptor beta 2. (437 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (880 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1592 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (520 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (469 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (785 aa)
HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. (913 aa)
LOC100346323Uncharacterized protein. (240 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC100356250Uncharacterized protein. (292 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
LOC100346856Uncharacterized protein. (316 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
HCAR1Hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (302 aa)
TshbThyroid-stimulating hormone beta subunit. (138 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
CAMK4Protein kinase domain-containing protein. (264 aa)
GNAI2G protein subunit alpha i2. (355 aa)
GCGGlucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity). (180 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (460 aa)
LOC100348967Uncharacterized protein. (316 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
GLI1GLI family zinc finger 1. (1103 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GRIN2CUncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (671 aa)
NPR1Guanylate cyclase. (1056 aa)
MC2RMelanocortin 2 receptor. (372 aa)
FXYD1Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. Belongs to the FXYD family. (119 aa)
SLC9A1Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. (1828 aa)
PPP1CASerine/threonine-protein phosphatase. (263 aa)
RAPGEF3Ras-GEF domain-containing protein. (195 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. (956 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (165 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (483 aa)
LHBLutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (141 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1019 aa)
HCAR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (576 aa)
CNGB1Cyclic nucleotide-binding domain-containing protein. (863 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (732 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (691 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
PDE4BPhosphodiesterase. (736 aa)
GHRLUncharacterized protein. (234 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
PDE10APhosphodiesterase. (791 aa)
PDE4DPhosphodiesterase. (808 aa)
CREB3cAMP responsive element binding protein 3. (377 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] (1352 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa)
RRAS2RAS related 2. (225 aa)
CREB5cAMP responsive element binding protein 5. (526 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1074 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1087 aa)
VAV3Vav guanine nucleotide exchange factor 3. (964 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
PAK1Non-specific serine/threonine protein kinase. (585 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (265 aa)
POMCNPP domain-containing protein. (285 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1017 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (312 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (915 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (584 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
RAP1AUncharacterized protein. (184 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
RAP1BUncharacterized protein. (184 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (632 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (964 aa)
LOC100356734Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1283 aa)
OXTOxytocin; Belongs to the vasopressin/oxytocin family. (173 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (358 aa)
EDN3Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. (210 aa)
PTGER3Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal ur [...] (438 aa)
LOC103349229FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (418 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (1043 aa)
HHIPHedgehog interacting protein. (700 aa)
GNASGNAS complex locus. (977 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1245 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.