STRINGSTRING
IL6ST IL6ST CCL24 CCL24 G1SDU7_RABIT G1SDU7_RABIT LOC100348776 LOC100348776 CCL20 CCL20 IL10RB IL10RB CCL27 CCL27 LTBR LTBR CXCR4 CXCR4 CCL5 CCL5 CCR1 CCR1 CCR2 CCR2 XCR1 XCR1 IL18 IL18 G1SPA3_RABIT G1SPA3_RABIT CCL11 CCL11 LTA LTA TNF TNF IL22RA1 IL22RA1 CX3CL1 CX3CL1 G1SU40_RABIT G1SU40_RABIT CCR9 CCR9 IL2 IL2 CCL28 CCL28 ACKR3 ACKR3 CCR8 CCR8 LOC100349255 LOC100349255 CCL1 CCL1 TNFRSF1B TNFRSF1B IL19 IL19 IL20 IL20 TNFSF10 TNFSF10 CCL22 CCL22 IL20RA IL20RA CXCL10 CXCL10 IL18R1 IL18R1 ACKR4 ACKR4 CCL2 CCL2 IL6 IL6 CCR7 CCR7 CCR5 CCR5 CXCR5 CXCR5 CCL14 CCL14 CXCL8 CXCL8 IL2RG IL2RG PPBP PPBP CXCL13 CXCL13 IL10 IL10 CCR10 CCR10 CCL21 CCL21 CCR6 CCR6 IL37 IL37 CX3CR1 CX3CR1 IL34 IL34 CSF1 CSF1 CXCL9 CXCL9 IL10RA IL10RA CXCR1 CXCR1 GRO-B GRO-B CXCR3 CXCR3 CCL7 CCL7 CCL19 CCL19 CCL25 CCL25 PF4 PF4 LOC100338113 LOC100338113 TNFRSF1A TNFRSF1A TNFSF14 TNFSF14 CXCL11 CXCL11 CXCR2 CXCR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6STInterleukin 6 signal transducer. (918 aa)
CCL24SCY domain-containing protein. (113 aa)
G1SDU7_RABITC-C motif chemokine. (104 aa)
LOC100348776C-C motif chemokine. (93 aa)
CCL20C-C motif chemokine. (96 aa)
IL10RBInterleukin 10 receptor subunit beta. (384 aa)
CCL27Uncharacterized protein. (257 aa)
LTBRLymphotoxin beta receptor. (414 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCL5C-C motif chemokine. (91 aa)
CCR1Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (369 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
IL18Uncharacterized protein. (408 aa)
G1SPA3_RABITUncharacterized protein. (226 aa)
CCL11SCY domain-containing protein. (96 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (197 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IL22RA1Interleukin 22 receptor subunit alpha 1. (679 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (404 aa)
G1SU40_RABITUncharacterized protein. (129 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
CCL28SCY domain-containing protein. (130 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (336 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
LOC100349255SCY domain-containing protein. (114 aa)
CCL1C-C motif chemokine. (190 aa)
TNFRSF1BTNF receptor superfamily member 1B. (425 aa)
IL19Interleukin 19. (233 aa)
IL20Interleukin 20. (187 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (304 aa)
CCL22C-C motif chemokine. (93 aa)
IL20RAInterleukin 20 receptor subunit alpha. (548 aa)
CXCL10C-X-C motif chemokine. (98 aa)
IL18R1Uncharacterized protein. (540 aa)
ACKR4Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
CCR5C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). (352 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
CCL14C-C motif chemokine ligand 14. (94 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IL2RGUncharacterized protein. (171 aa)
PPBPUncharacterized protein. (82 aa)
CXCL13C-X-C motif chemokine ligand 13. (105 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
IL37Interleukin-1. (280 aa)
CX3CR1CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. (356 aa)
IL34Interleukin 34. (200 aa)
CSF1Colony stimulating factor 1. (535 aa)
CXCL9C-X-C motif chemokine. (153 aa)
IL10RAInterleukin 10 receptor subunit alpha. (540 aa)
CXCR1C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. (355 aa)
GRO-BPermeability factor 2; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CCL7SCY domain-containing protein. (204 aa)
CCL19C-C motif chemokine. (109 aa)
CCL25SCY domain-containing protein. (159 aa)
PF4Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (105 aa)
LOC100338113Uncharacterized protein. (282 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
TNFSF14TNF superfamily member 14. (241 aa)
CXCL11C-X-C motif chemokine ligand 11. (110 aa)
CXCR2C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). (357 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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