(75 nodes) Phosphatidylinositol signaling system network (Oryctolagus cuniculus)

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	IPPK	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (551 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa)
	IPMK	Kinase; Belongs to the inositol phosphokinase (IPK) family. (416 aa)
	IP6K3	Kinase; Belongs to the inositol phosphokinase (IPK) family. (393 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (990 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (277 aa)
	IP6K1	Kinase; Belongs to the inositol phosphokinase (IPK) family. (433 aa)
	DGKH	Diacylglycerol kinase. (1257 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2074 aa)
	PLCE1	Phosphoinositide phospholipase C. (2300 aa)
	MTMR8	Myotubularin related protein 8. (692 aa)
	PIP4K2C	Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (284 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (443 aa)
	CDS2	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (445 aa)
	INPPL1	Inositol polyphosphate phosphatase like 1. (1362 aa)
	INPP1	Inositol polyphosphate-1-phosphatase. (398 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	PRKCB	Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
	INPP4B	Inositol polyphosphate-4-phosphatase type II B. (936 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (435 aa)
	DGKB	Diacylglycerol kinase. (803 aa)
	INPP4A	Inositol polyphosphate-4-phosphatase type I A. (1189 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2735 aa)
	MTMR3	Myotubularin related protein 3. (1219 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2616 aa)
	PLCD4	Phosphoinositide phospholipase C. (789 aa)
	PPIP5K2	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1263 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
	MTMR1	Myotubularin related protein 1. (655 aa)
	IMPA2	Uncharacterized protein. (366 aa)
	CDIPT	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (408 aa)
	DGKG	Diacylglycerol kinase. (807 aa)
	MTM1	Myotubularin 1. (658 aa)
	PIP5K1B	Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (612 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2756 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (899 aa)
	IMPAD1	Inositol monophosphatase domain containing 1. (368 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1673 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (901 aa)
	ENSOCUP00000028112	IPPc domain-containing protein. (330 aa)
	PI4KB	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (801 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PPIP5K1	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1408 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1686 aa)
	DGKI	Diacylglycerol kinase. (914 aa)
	SACM1L	SAC1 like phosphatidylinositide phosphatase. (587 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
	PLCZ1	Phosphoinositide phospholipase C. (639 aa)
	DGKK	Diacylglycerol kinase. (1230 aa)
	DGKA	Diacylglycerol kinase. (734 aa)
	SYNJ2	Synaptojanin 2. (1407 aa)
	ITPKA	Kinase; Belongs to the inositol phosphokinase (IPK) family. (443 aa)
	PLCD3	Phosphoinositide phospholipase C. (783 aa)
	CDS1	Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (480 aa)
	PI4K2B	Phosphatidylinositol 4-kinase type 2 beta. (429 aa)
	PIP4K2B	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (406 aa)
	PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (563 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1501 aa)
	MTMR2	Myotubularin related protein 2. (643 aa)
	IMPA1	Inositol monophosphatase 1. (438 aa)
	LOC100345250	Uncharacterized protein. (461 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
	MTMR6	Myotubularin related protein 6. (659 aa)
	DGKE	Diacylglycerol kinase. (567 aa)
	CALML5	Calmodulin like 5. (149 aa)
	IP6K2	Inositol hexakisphosphate kinase 2; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). (425 aa)
	CALM1	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
	MTMR4	Myotubularin related protein 4. (1195 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family. (2027 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	MTMR7	Myotubularin related protein 7. (660 aa)
	ITPKC	Kinase; Belongs to the inositol phosphokinase (IPK) family. (636 aa)
	PI4K2A	PI3K/PI4K domain-containing protein. (477 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM1	CALML5	ENSOCUP00000010025	ENSOCUP00000010863	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Calmodulin like 5.	0.938
CALM1	ITPKA	ENSOCUP00000010025	ENSOCUP00000018134	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.747
CALM1	ITPKC	ENSOCUP00000010025	ENSOCUP00000006789	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.600
CALM1	ITPR1	ENSOCUP00000010025	ENSOCUP00000030534	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Inositol 1,4,5-trisphosphate receptor type 1.	0.942
CALM1	ITPR2	ENSOCUP00000010025	ENSOCUP00000041911	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Inositol 1,4,5-trisphosphate receptor type 2.	0.936
CALM1	ITPR3	ENSOCUP00000010025	ENSOCUP00000039591	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Inositol 1,4,5-trisphosphate receptor type 3.	0.941
CALM1	PIK3C3	ENSOCUP00000010025	ENSOCUP00000029363	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.522
CALM1	PLCB1	ENSOCUP00000010025	ENSOCUP00000036536	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.927
CALM1	PLCB2	ENSOCUP00000010025	ENSOCUP00000005658	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.906
CALM1	PLCG1	ENSOCUP00000010025	ENSOCUP00000021041	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.936
CALM1	PLCG2	ENSOCUP00000010025	ENSOCUP00000011293	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.914
CALML5	CALM1	ENSOCUP00000010863	ENSOCUP00000010025	Calmodulin like 5.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).	0.938
CALML5	ITPKA	ENSOCUP00000010863	ENSOCUP00000018134	Calmodulin like 5.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.751
CALML5	ITPKC	ENSOCUP00000010863	ENSOCUP00000006789	Calmodulin like 5.	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.600
CALML5	ITPR1	ENSOCUP00000010863	ENSOCUP00000030534	Calmodulin like 5.	Inositol 1,4,5-trisphosphate receptor type 1.	0.942
CALML5	ITPR2	ENSOCUP00000010863	ENSOCUP00000041911	Calmodulin like 5.	Inositol 1,4,5-trisphosphate receptor type 2.	0.936
CALML5	ITPR3	ENSOCUP00000010863	ENSOCUP00000039591	Calmodulin like 5.	Inositol 1,4,5-trisphosphate receptor type 3.	0.941
CALML5	PIK3C3	ENSOCUP00000010863	ENSOCUP00000029363	Calmodulin like 5.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.524
CALML5	PLCB1	ENSOCUP00000010863	ENSOCUP00000036536	Calmodulin like 5.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.924
CALML5	PLCB2	ENSOCUP00000010863	ENSOCUP00000005658	Calmodulin like 5.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.906