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| | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa) |
| | GNAI1 | G protein subunit alpha i1. (349 aa) |
| | OPRD1 | Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (373 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | SPTLC3 | Serine palmitoyltransferase long chain base subunit 3. (551 aa) |
| | GNA12 | G protein subunit alpha 12. (457 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family. (553 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family. (467 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (453 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | MS4A2 | Membrane spanning 4-domains A2. (243 aa) |
| | RAC1 | Rac family small GTPase 1. (199 aa) |
| | SGMS2 | Sphingomyelin synthase 2. (365 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | SGMS1 | Sphingomyelin synthase 1. (419 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (328 aa) |
| | G1T1S8_RABIT | FA_desaturase domain-containing protein. (316 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (292 aa) |
| | CERS5 | Ceramide synthase 5. (326 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa) |
| | PLD1 | Phospholipase. (1031 aa) |
| | LOC100345250 | Uncharacterized protein. (461 aa) |
| | BDKRB2 | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. (446 aa) |
| | S1PR3 | Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (367 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1316 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | NSMAF | Neutral sphingomyelinase activation associated factor. (920 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (210 aa) |
| | GNAQ | G protein subunit alpha q. (325 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (542 aa) |
| | ASAH2 | Neutral ceramidase. (759 aa) |
| | GAB2 | GRB2 associated binding protein 2. (679 aa) |
| | LOC100356250 | Uncharacterized protein. (292 aa) |
| | LOC100346856 | Uncharacterized protein. (316 aa) |
| | ADORA3 | Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. (319 aa) |
| | TRADD | TNFRSF1A associated via death domain. (447 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | LOC100348967 | Uncharacterized protein. (316 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (255 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (521 aa) |
| | DEGS1 | FA_desaturase domain-containing protein. (287 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | FCER1A | Fc fragment of IgE receptor Ia. (245 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. (434 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CERS3 | Ceramide synthase 3. (411 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity). (542 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (509 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
| | SPHK1 | Sphingosine kinase 1. (455 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (564 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (439 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1686 aa) |
| | KNG1 | Kininogen 1. (633 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (85 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (428 aa) |
| | CERS6 | Ceramide synthase 6. (392 aa) |
| | DEGS2 | Lipid_DES domain-containing protein. (565 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (416 aa) |
| | ROCK1 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] (1352 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (447 aa) |
| | BCL2 | BH4_2 domain-containing protein. (389 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (495 aa) |
| | PPP2R3A | Protein phosphatase 2 regulatory subunit B''alpha. (1143 aa) |
| | S1PR2 | G_PROTEIN_RECEP_F1_2 domain-containing protein. (353 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (590 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta. (714 aa) |
| | SGPP1 | acidPPc domain-containing protein. (558 aa) |
| | S1PR5 | Sphingosine-1-phosphate receptor 5; Belongs to the G-protein coupled receptor 1 family. (399 aa) |
| | PPP2R3B | EF-hand domain-containing protein. (577 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (472 aa) |
| | CERS4 | Ceramide synthase 4. (441 aa) |
| | PRKCB | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa) |
| | ASAH1 | N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (412 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (399 aa) |
