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| | CDC26 | Cell division cycle 26. (85 aa) |
| | UBE2U | Ubiquitin conjugating enzyme E2 U; Belongs to the ubiquitin-conjugating enzyme family. (320 aa) |
| | UBE2J2 | Ubiquitin conjugating enzyme E2 J2. (252 aa) |
| | WWP1 | E3 ubiquitin-protein ligase. (877 aa) |
| | UBB | Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...] (288 aa) |
| | UBA2 | Ubiquitin like modifier activating enzyme 2. (756 aa) |
| | CUL7 | Cullin 7; Belongs to the cullin family. (1728 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1140 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | PML | Promyelocytic leukemia. (860 aa) |
| | UBE4A | Ubiquitination factor E4A. (1073 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (775 aa) |
| | UBE2L3 | Ubiquitin conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family. (211 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | BIRC7 | Baculoviral IAP repeat containing 7. (278 aa) |
| | ANAPC13 | Uncharacterized protein. (299 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (389 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1852 aa) |
| | CBL | Cbl proto-oncogene. (837 aa) |
| | UBE2J1 | Ubiquitin conjugating enzyme E2 J1. (318 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (733 aa) |
| | CBLB | Cbl proto-oncogene B. (983 aa) |
| | UBE2K | Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa) |
| | BIRC6 | Baculoviral IAP repeat containing 6. (4863 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4806 aa) |
| | NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1315 aa) |
| | HUWE1 | HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4329 aa) |
| | UBA3 | Ubiquitin like modifier activating enzyme 3. (463 aa) |
| | UBA1 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity). (1058 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | KLHL9 | Kelch like family member 9. (617 aa) |
| | UBR5 | Ubiquitin protein ligase E3 component n-recognin 5. (2769 aa) |
| | SKP2 | F-box domain-containing protein. (435 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | SLC35E3 | Uncharacterized protein. (767 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (759 aa) |
| | BIRC3 | Baculoviral IAP repeat containing 3. (591 aa) |
| | ELOB | Elongin B. (118 aa) |
| | UBE2W | UBIQUITIN_CONJUGAT_2 domain-containing protein. (179 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (868 aa) |
| | CUL5 | Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (780 aa) |
| | LOC100343655 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | RHOBTB1 | Rho related BTB domain containing 1. (696 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (747 aa) |
| | UBA6 | Ubiquitin like modifier activating enzyme 6. (1052 aa) |
| | UBE2S | Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (208 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (597 aa) |
| | CUL2 | Cullin 2; Belongs to the cullin family. (745 aa) |
| | HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4860 aa) |
| | ITCH | E3 ubiquitin-protein ligase. (864 aa) |
| | PRPF19 | Pre-mRNA processing factor 19. (504 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (737 aa) |
| | UBE2M | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa) |
| | UBE2B-2 | Ubiquitin-conjugating enzyme E2 B; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiqui [...] (287 aa) |
| | DET1 | Uncharacterized protein. (553 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1944 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (520 aa) |
| | UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (881 aa) |
| | TRIM32 | Tripartite motif containing 32. (659 aa) |
| | PPIL2 | Peptidylprolyl isomerase like 2. (522 aa) |
| | ANAPC11 | RING-type domain-containing protein. (84 aa) |
| | CDC34 | Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (227 aa) |
| | SKP1 | Uncharacterized protein; Belongs to the SKP1 family. (163 aa) |
| | RHOBTB2 | Rho related BTB domain containing 2. (749 aa) |
| | UBE2L6 | Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | CDC27 | Cell division cycle 27. (825 aa) |
| | UBE2G1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | PARK2 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (394 aa) |
| | G1TZG8_RABIT | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (115 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1446 aa) |
| | SIAH1 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (315 aa) |
| | UBE2R2 | Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin; Belongs to the ubiquitin-conjugating enzyme family. (238 aa) |
| | UBA7 | Ubiquitin like modifier activating enzyme 7; Belongs to the ubiquitin-activating E1 family. (1021 aa) |
| | UBE2I | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (96 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa) |
| | UBE2D2 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (317 aa) |
| | LOC100354960 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (305 aa) |
| | UBE3B | Ubiquitin protein ligase E3B. (1096 aa) |
| | VHL | Uncharacterized protein. (191 aa) |
| | XIAP | RING-type domain-containing protein. (633 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2; Belongs to the glycosyltransferase 29 family. (911 aa) |
| | UBE2Z | Ubiquitin conjugating enzyme E2 Z. (291 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (771 aa) |
| | UBE2D1 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | KLHL13 | Kelch like family member 13. (658 aa) |
| | PIAS1 | Protein inhibitor of activated STAT 1. (916 aa) |
| | FBXW8 | F-box and WD repeat domain containing 8. (598 aa) |
| | ELOC | Elongin C; Belongs to the SKP1 family. (112 aa) |
| | UBE2G2 | Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (198 aa) |
| | UBE2Q2 | Ubiquitin-conjugating enzyme E2 Q2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. (370 aa) |
| | UBE2F | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa) |
| | TRIP12 | Thyroid hormone receptor interactor 12. (2040 aa) |
| | LOC100343047 | Ubiquitin-like domain-containing protein. (77 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1408 aa) |
| | UBE2D3 | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | NEDD4L | NEDD4 like E3 ubiquitin protein ligase. (1239 aa) |
| | LOC100345190 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (901 aa) |
| | UBE2H | Ubiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family. (212 aa) |
| | UBE2Q1 | Ubiquitin conjugating enzyme E2 Q1. (378 aa) |
| | UBE3C | Ubiquitin protein ligase E3C. (1127 aa) |
| | TRIM37 | Tripartite motif containing 37. (967 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (410 aa) |
| | KEAP1 | Kelch like ECH associated protein 1. (631 aa) |
| | ENSOCUP00000046087 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (97 aa) |
| | HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1057 aa) |
| | LOC100344750 | HECT domain-containing protein. (1050 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (269 aa) |
| | MGRN1 | Mahogunin ring finger 1. (660 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (623 aa) |
| | FANCL | FA complementation group L. (414 aa) |
