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DEPTOR DEPTOR PRKAA1 PRKAA1 RAB7A RAB7A MAP3K7 MAP3K7 WIPI2 WIPI2 PDPK1 PDPK1 VAMP8 VAMP8 PIK3R4 PIK3R4 BNIP3 BNIP3 BCL2L1 BCL2L1 RRAGA RRAGA VMP1 VMP1 STX17 STX17 RAB39B RAB39B PIK3CB PIK3CB PRKAA2 PRKAA2 PIK3R1 PIK3R1 MRAS MRAS C9orf72 C9orf72 EIF2AK4 EIF2AK4 NRBF2 NRBF2 GABARAP GABARAP IRS1 IRS1 ATG4C ATG4C ATG9B ATG9B PTEN PTEN TP53INP2 TP53INP2 MTMR4 MTMR4 MAPK10 MAPK10 IRS4 IRS4 CFLAR CFLAR KRAS KRAS EIF2AK3 EIF2AK3 RUBCN RUBCN MTOR MTOR RHEB RHEB MAPK1 MAPK1 MAPK3 MAPK3 ATG4D ATG4D LOC100345250 LOC100345250 ATG2B ATG2B ATG9A ATG9A SQSTM1 SQSTM1 ATG3 ATG3 PPP2CA PPP2CA BECN1 BECN1 RRAGC RRAGC GABARAPL2 GABARAPL2 DDIT4 DDIT4 TMEM52B TMEM52B RAB1A RAB1A LOC100347623 LOC100347623 WIPI1 WIPI1 BECN2 BECN2 LOC100356256 LOC100356256 UVRAG UVRAG ATG16L1 ATG16L1 TANK TANK MAPK8 MAPK8 NRAS NRAS LAMP1 LAMP1 INS INS CTSD CTSD PIK3CD PIK3CD ATG101 ATG101 ATG4B ATG4B SMCR8 SMCR8 HMGB1 HMGB1 RRAGB RRAGB ULK1 ULK1 LOC100344030 LOC100344030 PIK3CA PIK3CA ATG16L2 ATG16L2 TRAF6 TRAF6 PRAP1 PRAP1 MAP2K1 MAP2K1 ZFYVE1 ZFYVE1 PIK3C3 PIK3C3 RAB7B RAB7B ITPR1 ITPR1 LOC100339305 LOC100339305 MAPK9 MAPK9 CTSB CTSB ATG7 ATG7 WDR41 WDR41 ATG4A ATG4A RRAS2 RRAS2 RB1CC1 RB1CC1 TBK1 TBK1 BCL2 BCL2 RAF1 RAF1 LOC100346703 LOC100346703 ATG12 ATG12 CTSV CTSV LAMP2 LAMP2 SH3GLB1 SH3GLB1 TSC1 TSC1 MLST8 MLST8 RRAGD RRAGD MTMR3 MTMR3 HIF1A HIF1A AKT3 AKT3 DAPK2 DAPK2 ENSOCUP00000043082 ENSOCUP00000043082 PRKACB PRKACB ATG14 ATG14 DAPK1 DAPK1 SNAP29 SNAP29 ATG10 ATG10 ULK2 ULK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEPTORDEP domain containing MTOR interacting protein. (498 aa)
PRKAA1Non-specific serine/threonine protein kinase. (656 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (207 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (552 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1373 aa)
BNIP3BCL2 interacting protein 3. (218 aa)
BCL2L1Bcl-X. (233 aa)
RRAGARas related GTP binding A. (313 aa)
VMP1Vacuole membrane protein 1. (406 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (303 aa)
RAB39BRAB39B, member RAS oncogene family (Predicted). (213 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKAA2Non-specific serine/threonine protein kinase. (537 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
NRBF2Nuclear receptor binding factor 2. (288 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein; Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa)
IRS1Insulin receptor substrate 1. (1220 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (923 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TP53INP2Uncharacterized protein. (124 aa)
MTMR4Myotubularin related protein 4. (1195 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
IRS4Insulin receptor substrate 4. (1176 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (507 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1033 aa)
RUBCNRubicon autophagy regulator. (971 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (328 aa)
LOC100345250Uncharacterized protein. (461 aa)
ATG2BAutophagy related 2B. (1986 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
SQSTM1Sequestosome 1. (518 aa)
ATG3Autophagy-related protein 3. (314 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
BECN1Uncharacterized protein. (448 aa)
RRAGCRas related GTP binding C. (387 aa)
GABARAPL2GABA type A receptor associated protein like 2. (117 aa)
DDIT4DNA damage inducible transcript 4. (229 aa)
TMEM52BUncharacterized protein. (295 aa)
RAB1ARAB1A, member RAS oncogene family. (205 aa)
LOC100347623Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (428 aa)
BECN2Beclin 2. (426 aa)
LOC100356256Uncharacterized protein; Belongs to the peptidase C1 family. (369 aa)
UVRAGUV radiation resistance associated. (698 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LAMP1Lysosomal associated membrane protein 1. (412 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
CTSDPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (255 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
ATG101Autophagy related 101. (217 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (388 aa)
SMCR8SMCR8-C9orf72 complex subunit. (930 aa)
HMGB1High-mobility group box 1 (Predicted). (215 aa)
RRAGBRas related GTP binding B. (386 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1001 aa)
LOC100344030Uncharacterized protein; Belongs to the peptidase C1 family. (344 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ATG16L2Autophagy related 16 like 2. (578 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
PRAP1Uncharacterized protein. (189 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (801 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (899 aa)
RAB7BUncharacterized protein. (280 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2756 aa)
LOC100339305Uncharacterized protein. (506 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (456 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (864 aa)
WDR41WD_REPEATS_REGION domain-containing protein. (278 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (402 aa)
RRAS2RAS related 2. (225 aa)
RB1CC1RB1 inducible coiled-coil 1. (1606 aa)
TBK1TANK binding kinase 1. (836 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
LOC100346703Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (141 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (131 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (356 aa)
LAMP2Lysosomal associated membrane protein 2. (533 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (588 aa)
TSC1Uncharacterized protein. (988 aa)
MLST8MTOR associated protein, LST8 homolog. (419 aa)
RRAGDRas related GTP binding D. (413 aa)
MTMR3Myotubularin related protein 3. (1219 aa)
HIF1AUncharacterized protein. (851 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
ENSOCUP00000043082Uncharacterized protein. (319 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ATG14Autophagy related 14. (551 aa)
DAPK1Death associated protein kinase 1. (1493 aa)
SNAP29t-SNARE coiled-coil homology domain-containing protein. (305 aa)
ATG10Autophagy_act_C domain-containing protein. (341 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1066 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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