STRINGSTRING
RAB7B RAB7B ITGA2 ITGA2 ATP6V1G3 ATP6V1G3 ATP6V1B2 ATP6V1B2 RAB7A RAB7A TAP1 TAP1 TUBB TUBB TLR4 TLR4 HLA-DQB2 HLA-DQB2 CD36 CD36 PIKFYVE PIKFYVE MRC1 MRC1 TLR2 TLR2 LOC100358696 LOC100358696 ITGB1 ITGB1 THBS1 THBS1 CD14 CD14 DYNC1LI2 DYNC1LI2 ATP6V0B ATP6V0B TLR6 TLR6 ATP6V0E1 ATP6V0E1 G1SR88_RABIT G1SR88_RABIT MARCO MARCO ATP6V1E1 ATP6V1E1 ATP6V0C ATP6V0C HLA-DPB1 HLA-DPB1 HLA-DRA HLA-DRA THBS4 THBS4 SEC61A2 SEC61A2 RAC1 RAC1 THBS3 THBS3 ATP6V0D2 ATP6V0D2 CD209 CD209 CTSS CTSS ATP6V0D1 ATP6V0D1 RAB5A RAB5A DYNC1I1 DYNC1I1 MBL2 MBL2 RAB5C RAB5C ITGA5 ITGA5 ATP6V0A4 ATP6V0A4 G1T5W0_RABIT G1T5W0_RABIT RAB5B RAB5B ATP6V1F ATP6V1F ATP6V0E2 ATP6V0E2 ITGB5 ITGB5 PLA2R1 PLA2R1 ATP6V0A1 ATP6V0A1 ATP6V1H ATP6V1H TUBA3E TUBA3E CLEC7A CLEC7A LOC100347623 LOC100347623 TFRC TFRC ATP6AP1 ATP6AP1 M6PR M6PR LOC100356256 LOC100356256 MRC2 MRC2 TUBA8 TUBA8 HLA-DMA HLA-DMA TUBB6 TUBB6 SFTPD SFTPD IGHM-2 IGHM-2 LOC100357567 LOC100357567 TAP2 TAP2 SEC61G SEC61G TUBA4A TUBA4A LAMP1 LAMP1 NCF4 NCF4 MSR1 MSR1 RLA-DMB RLA-DMB COLEC12 COLEC12 G1TYN5_RABIT G1TYN5_RABIT ATP6V1G2 ATP6V1G2 CALR CALR TUBB3 TUBB3 CANX CANX ATP6V1G1 ATP6V1G1 IGHM-3 IGHM-3 LOC100344030 LOC100344030 LOC100337909 LOC100337909 STX7 STX7 ATP6V1C2 ATP6V1C2 ITGAM ITGAM PIK3C3 PIK3C3 CTSV CTSV LAMP2 LAMP2 ITGAV ITGAV LOC100359306 LOC100359306 TUBA3D TUBA3D ITGB2 ITGB2 ENSOCUP00000041377 ENSOCUP00000041377 SEC61B SEC61B LOC100355380 LOC100355380 MPO MPO LOC100349667 LOC100349667 COLEC11 COLEC11 LOC100349085 LOC100349085 ACTB ACTB ENSOCUP00000046413 ENSOCUP00000046413 HLA-DOB HLA-DOB DYNC2H1 DYNC2H1 NCF2 NCF2 ATP6V1C1 ATP6V1C1 SEC22B SEC22B ATP6V0A2 ATP6V0A2 TUBA1B TUBA1B FCGR2A FCGR2A OLR1 OLR1 SEC61A1 SEC61A1 TUBAL3 TUBAL3 ITGB3 ITGB3 ATP6V1D ATP6V1D SFTPA1 SFTPA1 VAMP3 VAMP3 DYNC1I2 DYNC1I2 STX18 STX18 ENSOCUP00000035377 ENSOCUP00000035377 LOC100338913 LOC100338913 ENSOCUP00000037393 ENSOCUP00000037393
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB7BUncharacterized protein. (280 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
RAB7ARas-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (207 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (742 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (305 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2074 aa)
MRC1Mannose receptor C-type 1. (1455 aa)
TLR2TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa)
LOC100358696Uncharacterized protein. (397 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (830 aa)
THBS1Thrombospondin 1. (1171 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (628 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (283 aa)
TLR6TIR domain-containing protein; Belongs to the Toll-like receptor family. (795 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
G1SR88_RABITIg-like domain-containing protein; Belongs to the MHC class I family. (264 aa)
MARCOMacrophage receptor with collagenous structure. (516 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (265 aa)
HLA-DPB1RLA class II histocompatibility antigen, DP beta chain. (253 aa)
HLA-DRAIntegral membrane protein; Belongs to the MHC class II family. (255 aa)
THBS4Thrombospondin 4. (997 aa)
SEC61A2SEC61 translocon alpha 2 subunit. (476 aa)
RAC1Rac family small GTPase 1. (199 aa)
THBS3Thrombospondin 3. (911 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
CD209C-type lectin domain-containing protein. (239 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (340 aa)
ATP6V0D1ATPase H+ transporting V0 subunit d1. (541 aa)
RAB5AUncharacterized protein. (215 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (653 aa)
MBL2Mannose binding lectin 2. (247 aa)
RAB5CUncharacterized protein. (216 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
G1T5W0_RABITTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (367 aa)
RAB5BRAB5B, member RAS oncogene family. (290 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (799 aa)
PLA2R1Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marro [...] (1458 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
TUBA3ETHAP-type domain-containing protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (780 aa)
CLEC7AC-type lectin domain containing 7A. (247 aa)
LOC100347623Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
TFRCTransferrin receptor. (763 aa)
ATP6AP1Uncharacterized protein. (470 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (285 aa)
LOC100356256Uncharacterized protein; Belongs to the peptidase C1 family. (369 aa)
MRC2Mannose receptor C type 2. (1040 aa)
TUBA8Tubulin alpha 8; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (743 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (234 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (534 aa)
SFTPDSurfactant protein D. (350 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
LOC100357567Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
TAP2Uncharacterized protein. (703 aa)
SEC61GSEC61 translocon gamma subunit. (68 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
LAMP1Lysosomal associated membrane protein 1. (412 aa)
NCF4P40-phox. (340 aa)
MSR1Macrophage scavenger receptor types I and II; Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). (466 aa)
RLA-DMBIg-like domain-containing protein. (257 aa)
COLEC12Collectin subfamily member 12. (739 aa)
G1TYN5_RABITIg-like domain-containing protein. (119 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
CALRCalreticulin. (413 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (502 aa)
CANXCalnexin. (622 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (162 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
LOC100344030Uncharacterized protein; Belongs to the peptidase C1 family. (344 aa)
LOC100337909Uncharacterized protein. (325 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (282 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1258 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (899 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (356 aa)
LAMP2Lysosomal associated membrane protein 2. (533 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
LOC100359306Uncharacterized protein. (360 aa)
TUBA3DTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
ITGB2Integrin beta. (1009 aa)
ENSOCUP00000041377Ig-like domain-containing protein. (148 aa)
SEC61BUncharacterized protein. (127 aa)
LOC100355380Ig-like domain-containing protein; Belongs to the MHC class I family. (445 aa)
MPOMyeloperoxidase. (725 aa)
LOC100349667Ig-like domain-containing protein. (292 aa)
COLEC11Uncharacterized protein. (473 aa)
LOC100349085Ig-like domain-containing protein; Belongs to the MHC class I family. (418 aa)
ACTBUncharacterized protein. (357 aa)
ENSOCUP00000046413MHC_II_beta domain-containing protein. (169 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (265 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4313 aa)
NCF2Uncharacterized protein. (542 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (387 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (219 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (628 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
FCGR2AUncharacterized protein. (323 aa)
OLR1Oxidized low-density lipoprotein receptor 1, soluble form; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses includin [...] (367 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (482 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (873 aa)
ATP6V1DV-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). (259 aa)
SFTPA1Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. (416 aa)
VAMP3Vesicle associated membrane protein 3. (128 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (638 aa)
STX18Syntaxin 18. (358 aa)
ENSOCUP00000035377Ig-like domain-containing protein. (160 aa)
LOC100338913Uncharacterized protein. (325 aa)
ENSOCUP00000037393Uncharacterized protein. (92 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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