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| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (623 aa) |
| | RAD9B | Uncharacterized protein. (637 aa) |
| | CDC25A | Cell division cycle 25A. (491 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (399 aa) |
| | VDAC2 | Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules. (439 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (358 aa) |
| | LOC100349085 | Ig-like domain-containing protein; Belongs to the MHC class I family. (418 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (695 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (900 aa) |
| | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. (260 aa) |
| | LIN54 | Lin-54 DREAM MuvB core complex component. (749 aa) |
| | LOC100355380 | Ig-like domain-containing protein; Belongs to the MHC class I family. (445 aa) |
| | TRAF3IP2 | SEFIR domain-containing protein. (559 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2735 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | RB1 | RB transcriptional corepressor 1. (943 aa) |
| | TRPM7 | Transient receptor potential cation channel subfamily M member 7. (1822 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2616 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa) |
| | TSC1 | Uncharacterized protein. (988 aa) |
| | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. (263 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa) |
| | RRAS2 | RAS related 2. (225 aa) |
| | E2F2 | E2F transcription factor 2. (440 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (416 aa) |
| | RASSF5 | Ras association domain family member 5. (324 aa) |
| | LOC103345451 | TGFb_propeptide domain-containing protein. (203 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (544 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2756 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (933 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (762 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (574 aa) |
| | LIN37 | Lin-37 DREAM MuvB core complex component. (306 aa) |
| | LIN52 | Lin-52 DREAM MuvB core complex component. (128 aa) |
| | SMAD3 | SMAD family member 3. (230 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (467 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1249 aa) |
| | ETS1 | Uncharacterized protein. (533 aa) |
| | G1U6D1_RABIT | E2F_TDP domain-containing protein. (407 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase. (263 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | SIRT1 | Sirtuin 1. (748 aa) |
| | SLC25A4 | ADP/ATP translocase 1; Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane; Belongs to the mitochondrial carrier (TC 2.A.29) family. (288 aa) |
| | LOC100340625 | ANK_REP_REGION domain-containing protein. (324 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (424 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (518 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (262 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | VDAC3 | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (284 aa) |
| | CAPN2 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. (832 aa) |
| | RBBP4 | WD_REPEATS_REGION domain-containing protein. (390 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | GATA4 | GATA binding protein 4. (444 aa) |
| | FOXM1 | Forkhead box M1. (757 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1447 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (679 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (405 aa) |
| | MYBL2 | MYB proto-oncogene like 2. (697 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1068 aa) |
| | MRAS | Muscle RAS oncogene homolog. (208 aa) |
| | RBL2 | RB transcriptional corepressor like 2. (1140 aa) |
| | NFATC1 | RHD domain-containing protein. (672 aa) |
| | G1SR88_RABIT | Ig-like domain-containing protein; Belongs to the MHC class I family. (264 aa) |
| | PPID | Peptidylprolyl isomerase D. (369 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4. (616 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (337 aa) |
| | VDAC1 | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (283 aa) |
| | SLC35E3 | Uncharacterized protein. (767 aa) |
| | E2F4 | E2F_TDP domain-containing protein. (395 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1070 aa) |
| | CCNB3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (1035 aa) |
| | FOXO3 | Fork-head domain-containing protein. (675 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | TGFB3 | Transforming growth factor beta 3. (458 aa) |
| | CALM1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (138 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | E2F5 | E2F_CC-MB domain-containing protein. (184 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa) |
| | RHEB | Ras homolog, mTORC1 binding. (184 aa) |
| | SLC25A5 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (149 aa) |
| | CACNA1D | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2141 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | MAPKAPK2 | MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] (379 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa) |
| | LOC100345250 | Uncharacterized protein. (461 aa) |
| | E2F3 | E2F transcription factor 3. (462 aa) |
| | FOXO1 | Fork-head domain-containing protein. (613 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | MCU | Mitochondrial calcium uniporter. (350 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (680 aa) |
| | SQSTM1 | Sequestosome 1. (518 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (320 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1228 aa) |
| | CCNA1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa) |
| | CDKN1A | Uncharacterized protein. (231 aa) |
| | G1TC56_RABIT | TGFb_propeptide domain-containing protein. (168 aa) |
| | EIF4EBP1 | Eukaryotic translation initiation factor 4E binding protein 1. (118 aa) |
| | ZFP36L1 | Uncharacterized protein. (338 aa) |
