36 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MGRN1	Mahogunin ring finger 1. (660 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (775 aa)
	PTCH1	Patched 1. (1321 aa)
	GLI3	GLI family zinc finger 3. (1575 aa)
	SPOPL	Speckle type BTB/POZ protein like. (392 aa)
	BOC	BOC cell adhesion associated, oncogene regulated. (1111 aa)
	HHIP	Hedgehog interacting protein. (700 aa)
	LRP2	Uncharacterized protein. (2726 aa)
	PTCH2	Patched 2. (1198 aa)
	SMURF2	E3 ubiquitin-protein ligase. (747 aa)
	CSNK1G3	Casein kinase 1 gamma 3; Belongs to the protein kinase superfamily. (456 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa)
	SMURF1	E3 ubiquitin-protein ligase. (737 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
	MEGF8	Uncharacterized protein. (439 aa)
	GPR161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (546 aa)
	GLI1	GLI family zinc finger 1. (1103 aa)
	GRK3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	KIF3A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (724 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (578 aa)
	DHH	Desert hedgehog signaling molecule. (388 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (771 aa)
	EVC	Uncharacterized protein. (284 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	BCL2	BH4_2 domain-containing protein. (389 aa)
	LOC100341681	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (450 aa)
	MOSMO	Modulator of smoothened. (167 aa)
	CSNK1G1	Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (492 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	LOC100352479	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (332 aa)
	CSNK1D	Casein kinase I isoform delta. (429 aa)
	CDON	Cell adhesion associated, oncogene regulated. (1267 aa)
	GLI2	GLI family zinc finger 2. (1575 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (623 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CCND2	ENSOCUP00000036189	ENSOCUP00000013388	BH4_2 domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.778
BCL2	GLI1	ENSOCUP00000036189	ENSOCUP00000021386	BH4_2 domain-containing protein.	GLI family zinc finger 1.	0.483
BCL2	GLI2	ENSOCUP00000036189	ENSOCUP00000047570	BH4_2 domain-containing protein.	GLI family zinc finger 2.	0.445
BCL2	GSK3B	ENSOCUP00000036189	ENSOCUP00000034516	BH4_2 domain-containing protein.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.667
BCL2	PRKACB	ENSOCUP00000036189	ENSOCUP00000043583	BH4_2 domain-containing protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.560
BCL2	PTCH1	ENSOCUP00000036189	ENSOCUP00000002587	BH4_2 domain-containing protein.	Patched 1.	0.403
BCL2	SHH	ENSOCUP00000036189	ENSOCUP00000014488	BH4_2 domain-containing protein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.483
BCL2	SMO	ENSOCUP00000036189	ENSOCUP00000027051	BH4_2 domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.427
BOC	CDON	ENSOCUP00000009317	ENSOCUP00000047527	BOC cell adhesion associated, oncogene regulated.	Cell adhesion associated, oncogene regulated.	0.972
BOC	DHH	ENSOCUP00000009317	ENSOCUP00000027011	BOC cell adhesion associated, oncogene regulated.	Desert hedgehog signaling molecule.	0.992
BOC	HHIP	ENSOCUP00000009317	ENSOCUP00000049724	BOC cell adhesion associated, oncogene regulated.	Hedgehog interacting protein.	0.498
BOC	IHH	ENSOCUP00000009317	ENSOCUP00000025121	BOC cell adhesion associated, oncogene regulated.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.991
BOC	LRP2	ENSOCUP00000009317	ENSOCUP00000009497	BOC cell adhesion associated, oncogene regulated.	Uncharacterized protein.	0.904
BOC	PTCH1	ENSOCUP00000009317	ENSOCUP00000002587	BOC cell adhesion associated, oncogene regulated.	Patched 1.	0.988
BOC	PTCH2	ENSOCUP00000009317	ENSOCUP00000010757	BOC cell adhesion associated, oncogene regulated.	Patched 2.	0.967
BOC	SHH	ENSOCUP00000009317	ENSOCUP00000014488	BOC cell adhesion associated, oncogene regulated.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.991
BOC	SMO	ENSOCUP00000009317	ENSOCUP00000027051	BOC cell adhesion associated, oncogene regulated.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.965
BTRC	CSNK1D	ENSOCUP00000049583	ENSOCUP00000046345	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Casein kinase I isoform delta.	0.720
BTRC	CUL1	ENSOCUP00000049583	ENSOCUP00000002198	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 1; Belongs to the cullin family.	0.999
BTRC	CUL3	ENSOCUP00000049583	ENSOCUP00000031324	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 3; Belongs to the cullin family.	0.929