STRINGSTRING
BMPR1B BMPR1B ENSOCUP00000044284 ENSOCUP00000044284 RGMB RGMB GREM2 GREM2 RGMA RGMA INHBA INHBA TGIF2 TGIF2 ZFYVE9 ZFYVE9 ACVR1 ACVR1 CUL1 CUL1 THBS1 THBS1 FBN1 FBN1 SMAD4 SMAD4 CREBBP CREBBP FST FST INHBB INHBB TGFB2 TGFB2 RBL1 RBL1 SMAD6 SMAD6 HJV HJV TNF TNF TFDP1 TFDP1 DCN DCN INHBC INHBC INHBE INHBE BMP8B BMP8B GDF6 GDF6 NODAL NODAL ACVR1C ACVR1C FMOD FMOD LTBP1 LTBP1 E2F4 E2F4 GDF5 GDF5 BMP4 BMP4 SMAD2 SMAD2 TGFB3 TGFB3 EP300 EP300 BMP2 BMP2 CDKN2B CDKN2B PITX2 PITX2 SMURF2 SMURF2 E2F5 E2F5 RHOA RHOA SMAD5 SMAD5 MAPK1 MAPK1 MAPK3 MAPK3 TGIF1 TGIF1 MYC MYC PPP2CA PPP2CA SMURF1 SMURF1 ACVR2A ACVR2A G1TC56_RABIT G1TC56_RABIT BMPR1A BMPR1A PPP2R1A PPP2R1A ACVR1B ACVR1B LOC100356250 LOC100356250 LOC100346856 LOC100346856 LOC100341360 LOC100341360 GDF7 GDF7 ID3 ID3 BMP5 BMP5 SKP1 SKP1 LOC100348967 LOC100348967 GREM1 GREM1 LOC100101568 LOC100101568 HAMP HAMP NBL1 NBL1 G1U6D1_RABIT G1U6D1_RABIT ID1 ID1 SMAD3 SMAD3 ZFYVE16 ZFYVE16 LOC103345451 LOC103345451 SMAD1 SMAD1 ROCK1 ROCK1 TGFBR1 TGFBR1 BMPR2 BMPR2 SP1 SP1 ENSOCUP00000037329 ENSOCUP00000037329 NOG NOG PPP2R1B PPP2R1B AMHR2 AMHR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (474 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (184 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (325 aa)
INHBAInhibin subunit beta A. (424 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CUL1Cullin 1; Belongs to the cullin family. (775 aa)
THBS1Thrombospondin 1. (1171 aa)
FBN1Fibrillin 1. (2831 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CREBBPCREB binding protein. (2403 aa)
FSTFollistatin. (310 aa)
INHBBInhibin subunit beta B. (302 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
SMAD6MH2 domain-containing protein. (220 aa)
HJVHemojuvelin BMP co-receptor. (427 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
TFDP1Transcription factor. (410 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
INHBCInhibin subunit beta C. (351 aa)
INHBEInhibin subunit beta E. (352 aa)
BMP8BTGF_BETA_2 domain-containing protein. (374 aa)
GDF6Growth differentiation factor 6. (427 aa)
NODALNodal growth differentiation factor. (348 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (453 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1705 aa)
E2F4E2F_TDP domain-containing protein. (395 aa)
GDF5Growth differentiation factor 5 preproprotein (Predicted). (500 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
EP300E1A binding protein p300. (2418 aa)
BMP2Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
PITX2Homeobox protein. (352 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
E2F5E2F_CC-MB domain-containing protein. (184 aa)
RHOARas homolog family member A. (193 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
TGIF1TGFB induced factor homeobox 1. (452 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
SMURF1E3 ubiquitin-protein ligase. (737 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (542 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
LOC100356250Uncharacterized protein. (292 aa)
LOC100346856Uncharacterized protein. (316 aa)
LOC100341360TGF_BETA_2 domain-containing protein. (566 aa)
GDF7Growth differentiation factor 7. (546 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
LOC100348967Uncharacterized protein. (316 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
LOC100101568Left-right determination factor. (368 aa)
HAMPHepcidin antimicrobial peptide. (83 aa)
NBL1NBL1, DAN family BMP antagonist. (169 aa)
G1U6D1_RABITE2F_TDP domain-containing protein. (407 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SMAD3SMAD family member 3. (230 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1482 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ROCK1Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] (1352 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
SP1Sp1 transcription factor. (792 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (714 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (569 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.