STRINGSTRING
CSF1 CSF1 LCP2 LCP2 MAP3K7 MAP3K7 MITF MITF LOC100358696 LOC100358696 LCK LCK G1SMH0_RABIT G1SMH0_RABIT PIK3CB PIK3CB PIK3R1 PIK3R1 TGFB2 TGFB2 CREB1 CREB1 NOX1 NOX1 JAK1 JAK1 NFATC1 NFATC1 TNF TNF IL1R1 IL1R1 IKBKB IKBKB MAP2K6 MAP2K6 TEC TEC IL1A IL1A RAC1 RAC1 BTK BTK MAPK10 MAPK10 FOSL2 FOSL2 CTSK CTSK TNFRSF11B TNFRSF11B TAB2 TAB2 PLCG2 PLCG2 IFNGR1 IFNGR1 LOC100348748 LOC100348748 GRB2 GRB2 FOSB FOSB PPARG PPARG ENSOCUP00000044284 ENSOCUP00000044284 NFATC2 NFATC2 PPP3CA PPP3CA IKBKG IKBKG TNFRSF1A TNFRSF1A MAPK13 MAPK13 NCF2 NCF2 FHL2 FHL2 IFNAR1 IFNAR1 MAPK1 MAPK1 MAPK3 MAPK3 LOC100345250 LOC100345250 SQSTM1 SQSTM1 NFKBIA NFKBIA FYN FYN G1TC56_RABIT G1TC56_RABIT SYK SYK TNFSF11 TNFSF11 GAB2 GAB2 TAB1 TAB1 IFNAR2 IFNAR2 MAP2K7 MAP2K7 MAPK8 MAPK8 CAMK4 CAMK4 PPP3CB PPP3CB NCF4 NCF4 IFNB1 IFNB1 CALCR CALCR PIK3CD PIK3CD FOS FOS IL1B IL1B TYROBP TYROBP SIRPA SIRPA NFKB1 NFKB1 IFNGR2 IFNGR2 PIK3CA PIK3CA TRAF6 TRAF6 LOC100350239 LOC100350239 LOC100337909 LOC100337909 PPP3CC PPP3CC MAP2K1 MAP2K1 MAPK9 MAPK9 CHUK CHUK FCGR2A FCGR2A LOC103345451 LOC103345451 CYLD CYLD ITGB3 ITGB3 MAPK12 MAPK12 TGFBR1 TGFBR1 LOC100338913 LOC100338913 ENSOCUP00000037329 ENSOCUP00000037329 LOC100359306 LOC100359306 STAT1 STAT1 FOSL1 FOSL1 JUN JUN STAT2 STAT2 AKT3 AKT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSF1Colony stimulating factor 1. (535 aa)
LCP2Lymphocyte cytosolic protein 2. (534 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
LOC100358696Uncharacterized protein. (397 aa)
LCKTyrosine-protein kinase. (637 aa)
G1SMH0_RABITUncharacterized protein. (387 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NOX1NADPH oxidase 1. (564 aa)
JAK1Tyrosine-protein kinase. (1151 aa)
NFATC1RHD domain-containing protein. (672 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IL1R1Interleukin 1 receptor type 1. (699 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TECTyrosine-protein kinase. (631 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
RAC1Rac family small GTPase 1. (199 aa)
BTKTyrosine-protein kinase. (659 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family. (329 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
IFNGR1Interferon gamma receptor 1. (471 aa)
LOC100348748IGv domain-containing protein. (604 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (289 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
NFATC2Nuclear factor of activated T cells 2. (900 aa)
PPP3CASerine/threonine-protein phosphatase. (695 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
NCF2Uncharacterized protein. (542 aa)
FHL2Four and a half LIM domains 2. (306 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (541 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
LOC100345250Uncharacterized protein. (461 aa)
SQSTM1Sequestosome 1. (518 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
FYNTyrosine-protein kinase. (537 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
SYKTyrosine-protein kinase. (630 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
GAB2GRB2 associated binding protein 2. (679 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IFNAR2Uncharacterized protein. (523 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CAMK4Protein kinase domain-containing protein. (264 aa)
PPP3CBSerine/threonine-protein phosphatase. (518 aa)
NCF4P40-phox. (340 aa)
IFNB1Interferon beta 1. (180 aa)
CALCRCalcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Isoform 2 has altered ligand binding and abolished coupling to phospholipase C. (491 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (110 aa)
SIRPAUncharacterized protein. (563 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
IFNGR2Interferon gamma receptor 2. (449 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
LOC100350239Uncharacterized protein. (423 aa)
LOC100337909Uncharacterized protein. (325 aa)
PPP3CCSerine/threonine-protein phosphatase. (574 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
FCGR2AUncharacterized protein. (323 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (873 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
LOC100338913Uncharacterized protein. (325 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
LOC100359306Uncharacterized protein. (360 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (335 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
STAT2STAT_int domain-containing protein. (205 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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