STRINGSTRING
LOC100350202 LOC100350202 WNT5A WNT5A FGF2 FGF2 INHBA INHBA KAT6A KAT6A WNT8B WNT8B HOXB1 HOXB1 WNT11 WNT11 REST REST ACVR1 ACVR1 ONECUT1 ONECUT1 LIFR LIFR LIF LIF SMAD4 SMAD4 PIK3CB PIK3CB INHBB INHBB PIK3R1 PIK3R1 WNT8A WNT8A BMI1 BMI1 KLF4 KLF4 HESX1 HESX1 JAK1 JAK1 INHBC INHBC INHBE INHBE IL6ST IL6ST NODAL NODAL FZD6 FZD6 ACVR1C ACVR1C LHX5 LHX5 WNT10B WNT10B JARID2 JARID2 STAT3 STAT3 BMP4 BMP4 HAND1 HAND1 SMAD2 SMAD2 KRAS KRAS SETDB1 SETDB1 SKIL SKIL MAPK1 MAPK1 MAPK3 MAPK3 MYC MYC LOC100345250 LOC100345250 TBX3 TBX3 FZD2 FZD2 HOXD1 HOXD1 APC APC TCF7 TCF7 WNT10A WNT10A WNT2 WNT2 ACVR2A ACVR2A JAK2 JAK2 BMPR1A BMPR1A POU5F1 POU5F1 ZFHX3 ZFHX3 ACVR1B ACVR1B ZIC3 ZIC3 FZD9 FZD9 WNT2B WNT2B PCGF6 PCGF6 FZD5 FZD5 WNT6 WNT6 NRAS NRAS PAX6 PAX6 FZD7 FZD7 ID3 ID3 ISL1 ISL1 HOXA1 HOXA1 LOC100101568 LOC100101568 PIK3CD PIK3CD IGF1 IGF1 NANOG NANOG PCGF2 PCGF2 RIF1 RIF1 DUSP9 DUSP9 WNT9A WNT9A MYF5 MYF5 WNT16 WNT16 WNT1 WNT1 FZD3 FZD3 ID1 ID1 FZD8 FZD8 PIK3CA PIK3CA PCGF3 PCGF3 ESX1 ESX1 WNT7A WNT7A LOC103351908 LOC103351908 SMAD3 SMAD3 MAP2K1 MAP2K1 ENSOCUP00000033252 ENSOCUP00000033252 WNT3 WNT3 FGFR2 FGFR2 MAPK12 MAPK12 SMAD1 SMAD1 GSK3B GSK3B PCGF1 PCGF1 RAF1 RAF1 BMPR2 BMPR2 DLX5 DLX5 FGFR4 FGFR4 SMARCAD1 SMARCAD1 WNT5B WNT5B AKT3 AKT3 ESRRB ESRRB FGFR1 FGFR1 GRB2 GRB2 FZD4 FZD4 BMPR1B BMPR1B WNT9B WNT9B SMAD5 SMAD5 PCGF5 PCGF5 MAPK13 MAPK13 MEIS1 MEIS1 WNT3A WNT3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100350202Homeobox domain-containing protein. (482 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
INHBAInhibin subunit beta A. (424 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (774 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
HOXB1Homeobox B1. (300 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
RESTRE1 silencing transcription factor. (930 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ONECUT1One cut domain family member. (466 aa)
LIFRLIF receptor subunit alpha. (1091 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
INHBBInhibin subunit beta B. (302 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
BMI1RING-type domain-containing protein. (326 aa)
KLF4Uncharacterized protein. (145 aa)
HESX1Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. (189 aa)
JAK1Tyrosine-protein kinase. (1151 aa)
INHBCInhibin subunit beta C. (351 aa)
INHBEInhibin subunit beta E. (352 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
NODALNodal growth differentiation factor. (348 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
LHX5LIM homeobox 5. (402 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1242 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (215 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1292 aa)
SKILSKI like proto-oncogene. (683 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
LOC100345250Uncharacterized protein. (461 aa)
TBX3Uncharacterized protein. (242 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (668 aa)
HOXD1Homeobox D1. (319 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
TCF7Transcription factor 7. (319 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
POU5F1POU domain protein. (360 aa)
ZFHX3Zinc finger homeobox 3. (2758 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
ZIC3Zic family member 3. (467 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa)
PCGF6Polycomb group ring finger 6. (349 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PAX6Uncharacterized protein. (436 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
ISL1ISL LIM homeobox 1. (349 aa)
HOXA1Homeobox A1 isoform a (Predicted). (337 aa)
LOC100101568Left-right determination factor. (368 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
NANOGHomeobox domain-containing protein. (306 aa)
PCGF2Polycomb group ring finger 2. (324 aa)
RIF1Replication timing regulatory factor 1. (2455 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (465 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (538 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
FZD8G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (303 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PCGF3Polycomb group ring finger 3. (250 aa)
ESX1Homeobox domain-containing protein. (269 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
LOC103351908Homeobox domain-containing protein. (408 aa)
SMAD3SMAD family member 3. (230 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
ENSOCUP00000033252BZIP domain-containing protein. (172 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
PCGF1Polycomb group ring finger 1. (263 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
DLX5Distal-less homeobox 5. (313 aa)
FGFR4Fibroblast growth factor receptor. (862 aa)
SMARCAD1Uncharacterized protein. (1146 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (469 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
ESRRBEstrogen related receptor beta. (454 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (431 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
MEIS1Meis homeobox 1. (465 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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