STRINGSTRING
CTSK CTSK LOC100348776 LOC100348776 MAP3K7 MAP3K7 TLR4 TLR4 IRF7 IRF7 LOC100353390 LOC100353390 CCL5 CCL5 LOC100353390-2 LOC100353390-2 TLR2 TLR2 TRAF3 TRAF3 CD14 CD14 PIK3CB PIK3CB PIK3R1 PIK3R1 TLR6 TLR6 MAP3K8 MAP3K8 TNF TNF IKBKB IKBKB MAP2K6 MAP2K6 CD80 CD80 RAC1 RAC1 IRF5 IRF5 MAPK10 MAPK10 TIRAP TIRAP MAPK12 MAPK12 CD40 CD40 MYD88 MYD88 CD86 CD86 MAP2K4 MAP2K4 TBK1 TBK1 STAT1 STAT1 JUN JUN AKT3 AKT3 IKBKG IKBKG MAPK13 MAPK13 TLR9 TLR9 IFNAR1 IFNAR1 CXCL11 CXCL11 LBP LBP CASP8 CASP8 RIPK1 RIPK1 TAB2 TAB2 MAPK1 MAPK1 MAPK3 MAPK3 LOC100345250 LOC100345250 NFKBIA NFKBIA CXCL10 CXCL10 IL12B IL12B TLR3 TLR3 TAB1 TAB1 IFNAR2 IFNAR2 TICAM2 TICAM2 LOC100355669 LOC100355669 IL6 IL6 LOC100354654 LOC100354654 MAP2K7 MAP2K7 LOC100357194 LOC100357194 TOLLIP TOLLIP CXCL8 CXCL8 MAPK8 MAPK8 IFNB1 IFNB1 PIK3CD PIK3CD FOS FOS IL1B IL1B SPP1 SPP1 NFKB1 NFKB1 PIK3CA PIK3CA TRAF6 TRAF6 CXCL9 CXCL9 MAP2K1 MAP2K1 IRAK1 IRAK1 MAPK9 MAPK9 CHUK CHUK IRAK4 IRAK4
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family. (329 aa)
LOC100348776C-C motif chemokine. (93 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
IRF7Interferon regulatory factor 7. (438 aa)
LOC100353390Uncharacterized protein. (189 aa)
CCL5C-C motif chemokine. (91 aa)
LOC100353390-2Uncharacterized protein. (190 aa)
TLR2TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TLR6TIR domain-containing protein; Belongs to the Toll-like receptor family. (795 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (474 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CD80T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. (299 aa)
RAC1Rac family small GTPase 1. (199 aa)
IRF5Interferon regulatory factor 5. (500 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
CD40Uncharacterized protein. (494 aa)
MYD88Uncharacterized protein. (476 aa)
CD86T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. (336 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (520 aa)
TBK1TANK binding kinase 1. (836 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
TLR9TIR domain-containing protein. (1027 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (541 aa)
CXCL11C-X-C motif chemokine ligand 11. (110 aa)
LBPLipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (496 aa)
CASP8DED domain-containing protein. (109 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (670 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
LOC100345250Uncharacterized protein. (461 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CXCL10C-X-C motif chemokine. (98 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
IFNAR2Uncharacterized protein. (523 aa)
TICAM2TIR domain-containing protein. (241 aa)
LOC100355669Uncharacterized protein. (190 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
LOC100354654Uncharacterized protein. (189 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
LOC100357194Uncharacterized protein. (189 aa)
TOLLIPToll interacting protein. (274 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IFNB1Interferon beta 1. (180 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (311 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
CXCL9C-X-C motif chemokine. (153 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (464 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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