STRINGSTRING
IL17RA IL17RA IL13 IL13 TRAF4 TRAF4 CCL20 CCL20 MAP3K7 MAP3K7 TNFAIP3 TNFAIP3 MMP13 MMP13 ANAPC5 ANAPC5 CSF2 CSF2 TRAF3 TRAF3 IL5 IL5 IL17A IL17A IL17F IL17F USP25 USP25 CCL11 CCL11 TNF TNF IKBKB IKBKB TAB3 TAB3 S100A9 S100A9 TRAF5 TRAF5 S100A8 S100A8 CSF3 CSF3 MAPK10 MAPK10 TAB2 TAB2 MAPK6 MAPK6 MAPK4 MAPK4 IL17RB IL17RB MAPK1 MAPK1 MAPK3 MAPK3 HSP90AB1 HSP90AB1 MAPK7 MAPK7 MMP3 MMP3 NFKBIA NFKBIA ELAVL1 ELAVL1 IL17B IL17B CXCL10 CXCL10 HSP90B1 HSP90B1 PTGS2 PTGS2 SRSF1 SRSF1 MAPK15 MAPK15 CCL2 CCL2 CEBPB CEBPB IL6 IL6 TRADD TRADD CXCL8 CXCL8 MAPK8 MAPK8 LCN2 LCN2 FOS FOS IL1B IL1B NFKB1 NFKB1 G1U5C3_RABIT G1U5C3_RABIT MMP9 MMP9 IL4 IL4 TRAF6 TRAF6 GRO-B GRO-B IL25 IL25 MAPK9 MAPK9 CHUK CHUK MAPK12 MAPK12 GSK3B GSK3B TBK1 TBK1 MMP1 MMP1 CASP3 CASP3 CCL7 CCL7 FOSL1 FOSL1 JUN JUN TRAF3IP2 TRAF3IP2 FOSB FOSB IKBKG IKBKG MAPK13 MAPK13 CASP8 CASP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL17RAInterleukin 17 receptor A. (860 aa)
IL13Interleukin 13. (138 aa)
TRAF4TNF receptor-associated factor. (470 aa)
CCL20C-C motif chemokine. (96 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TNFAIP3TNF alpha induced protein 3. (787 aa)
MMP13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
CSF2Uncharacterized protein. (144 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL17AInterleukin 17A. (153 aa)
IL17FInterleukin 17F. (163 aa)
USP25Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1152 aa)
CCL11SCY domain-containing protein. (96 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (730 aa)
S100A9Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] (132 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
CSF3Colony stimulating factor 3. (204 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAPK6Mitogen-activated protein kinase 6. (722 aa)
MAPK4Mitogen-activated protein kinase 4. (552 aa)
IL17RBInterleukin 17 receptor B. (493 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
HSP90AB1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (726 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (818 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (382 aa)
IL17BInterleukin 17B. (175 aa)
CXCL10C-X-C motif chemokine. (98 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. (802 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
SRSF1Uncharacterized protein. (440 aa)
MAPK15Mitogen-activated protein kinase. (619 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
CEBPBCCAAT enhancer binding protein beta. (353 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
TRADDTNFRSF1A associated via death domain. (447 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LCN2Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (198 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
G1U5C3_RABITUncharacterized protein. (1020 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
GRO-BPermeability factor 2; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
IL25Interleukin 25. (177 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
TBK1TANK binding kinase 1. (836 aa)
MMP1Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
CCL7SCY domain-containing protein. (204 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (335 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
TRAF3IP2SEFIR domain-containing protein. (559 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (289 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
CASP8DED domain-containing protein. (109 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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