STRINGSTRING
PAK3 PAK3 CD3G CD3G LCP2 LCP2 MAP3K7 MAP3K7 ICOS ICOS PDPK1 PDPK1 ITK ITK CSF2 CSF2 LCK LCK CD40LG CD40LG IL5 IL5 PIK3CB PIK3CB PIK3R1 PIK3R1 CBLB CBLB ZAP70 ZAP70 SOS2 SOS2 MAP3K8 MAP3K8 NFATC1 NFATC1 TNF TNF IKBKB IKBKB TEC TEC NCK1 NCK1 PAK2 PAK2 CD8B CD8B NFATC3 NFATC3 IL2 IL2 DLG1 DLG1 MAPK10 MAPK10 PAK5 PAK5 CARD11 CARD11 PTPRC PTPRC KRAS KRAS GRAP2 GRAP2 CDK4 CDK4 RHOA RHOA MAPK1 MAPK1 MAPK3 MAPK3 LOC100345250 LOC100345250 NFKBIA NFKBIA FYN FYN BCL10 BCL10 LOC100356250 LOC100356250 LOC100346856 LOC100346856 CTLA4 CTLA4 NFKBIB NFKBIB MAP2K7 MAP2K7 MAPK8 MAPK8 CD3E CD3E IL10 IL10 NRAS NRAS SOS1 SOS1 PPP3CB PPP3CB LOC100348967 LOC100348967 PIK3CD PIK3CD PLCG1 PLCG1 FOS FOS PAK6 PAK6 NFKB1 NFKB1 NCK2 NCK2 CD28 CD28 IL4 IL4 CDC42-2 CDC42-2 PIK3CA PIK3CA CD247 CD247 PPP3CC PPP3CC MAP2K1 MAP2K1 CD4 CD4 MAPK9 MAPK9 CHUK CHUK PAK4 PAK4 MALT1 MALT1 ENSOCUP00000033540 ENSOCUP00000033540 MAPK12 MAPK12 GSK3B GSK3B VAV3 VAV3 RAF1 RAF1 PAK1 PAK1 RASGRP1 RASGRP1 JUN JUN CD3D CD3D PTPN6 PTPN6 AKT3 AKT3 PDCD1 PDCD1 GRB2 GRB2 NFATC2 NFATC2 PPP3CA PPP3CA IKBKG IKBKG CD8A CD8A MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAK3Non-specific serine/threonine protein kinase. (652 aa)
CD3GIGc2 domain-containing protein. (182 aa)
LCP2Lymphocyte cytosolic protein 2. (534 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ICOSInducible T cell costimulator. (222 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa)
ITKTyrosine-protein kinase. (611 aa)
CSF2Uncharacterized protein. (144 aa)
LCKTyrosine-protein kinase. (637 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CBLBCbl proto-oncogene B. (983 aa)
ZAP70Tyrosine-protein kinase. (623 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (474 aa)
NFATC1RHD domain-containing protein. (672 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TECTyrosine-protein kinase. (631 aa)
NCK1Cytoplasmic protein. (377 aa)
PAK2Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...] (524 aa)
CD8BIg-like domain-containing protein. (206 aa)
NFATC3Nuclear factor of activated T cells 3. (1070 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
CARD11Caspase recruitment domain family member 11. (1044 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GRAP2GRB2 related adaptor protein 2. (267 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa)
RHOARas homolog family member A. (193 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
LOC100345250Uncharacterized protein. (461 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
FYNTyrosine-protein kinase. (537 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
LOC100356250Uncharacterized protein. (292 aa)
LOC100346856Uncharacterized protein. (316 aa)
CTLA4Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (201 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
PPP3CBSerine/threonine-protein phosphatase. (518 aa)
LOC100348967Uncharacterized protein. (316 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
NCK2Cytoplasmic protein. (380 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
CDC42-2Uncharacterized protein. (222 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CD247T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of d [...] (239 aa)
PPP3CCSerine/threonine-protein phosphatase. (574 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
PAK4P21 (RAC1) activated kinase 4. (726 aa)
MALT1MALT1 paracaspase. (799 aa)
ENSOCUP00000033540Ig-like domain-containing protein. (203 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
VAV3Vav guanine nucleotide exchange factor 3. (964 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
PAK1Non-specific serine/threonine protein kinase. (585 aa)
RASGRP1RAS guanyl releasing protein 1. (798 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
CD3DIg_4 domain-containing protein. (177 aa)
PTPN6Protein tyrosine phosphatase non-receptor type 6. (561 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
PDCD1Ig-like domain-containing protein. (367 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
NFATC2Nuclear factor of activated T cells 2. (900 aa)
PPP3CASerine/threonine-protein phosphatase. (695 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
CD8AIg-like domain-containing protein. (394 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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