STRINGSTRING
ALOX5AP ALOX5AP IL13 IL13 LCP2 LCP2 PDPK1 PDPK1 LYN LYN CSF2 CSF2 IL5 IL5 PIK3CB PIK3CB PIK3R1 PIK3R1 ALOX5 ALOX5 SOS2 SOS2 TNF TNF MAP2K6 MAP2K6 MS4A2 MS4A2 RAC1 RAC1 BTK BTK MAPK10 MAPK10 PLA2G4B PLA2G4B KRAS KRAS PLCG2 PLCG2 MAPK1 MAPK1 MAPK3 MAPK3 PLA2G4D PLA2G4D LOC100345250 LOC100345250 PLA2G4A PLA2G4A PLA2G4C PLA2G4C FYN FYN SYK SYK GAB2 GAB2 MAP2K7 MAP2K7 IGHM-2 IGHM-2 MAPK8 MAPK8 NRAS NRAS SOS1 SOS1 PIK3CD PIK3CD PLCG1 PLCG1 FCER1A FCER1A G1TYN5_RABIT G1TYN5_RABIT IL4 IL4 IGHM-3 IGHM-3 PIK3CA PIK3CA MAP2K1 MAP2K1 MAPK9 MAPK9 PLA2G4E PLA2G4E FCER1G FCER1G MAPK12 MAPK12 PLA2G4F PLA2G4F ENSOCUP00000035377 ENSOCUP00000035377 MAP2K4 MAP2K4 VAV3 VAV3 RAF1 RAF1 ENSOCUP00000037393 ENSOCUP00000037393 AKT3 AKT3 ENSOCUP00000041377 ENSOCUP00000041377 GRB2 GRB2 MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALOX5APArachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity); Belongs to the MAPEG family. (229 aa)
IL13Interleukin 13. (138 aa)
LCP2Lymphocyte cytosolic protein 2. (534 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa)
LYNTyrosine-protein kinase. (636 aa)
CSF2Uncharacterized protein. (144 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MS4A2Membrane spanning 4-domains A2. (243 aa)
RAC1Rac family small GTPase 1. (199 aa)
BTKTyrosine-protein kinase. (659 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
PLA2G4BPhospholipase A2. (779 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
PLA2G4DPhospholipase A2. (825 aa)
LOC100345250Uncharacterized protein. (461 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (748 aa)
PLA2G4CPLA2c domain-containing protein. (829 aa)
FYNTyrosine-protein kinase. (537 aa)
SYKTyrosine-protein kinase. (630 aa)
GAB2GRB2 associated binding protein 2. (679 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
FCER1AFc fragment of IgE receptor Ia. (245 aa)
G1TYN5_RABITIg-like domain-containing protein. (119 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
PLA2G4EPhospholipase A2. (854 aa)
FCER1GFc fragment of IgE receptor Ig. (85 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
PLA2G4FPhospholipase A2. (897 aa)
ENSOCUP00000035377Ig-like domain-containing protein. (160 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (520 aa)
VAV3Vav guanine nucleotide exchange factor 3. (964 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
ENSOCUP00000037393Uncharacterized protein. (92 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
ENSOCUP00000041377Ig-like domain-containing protein. (148 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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