STRINGSTRING
CX3CL1 CX3CL1 CCL20 CCL20 MAP3K7 MAP3K7 TNFAIP3 TNFAIP3 CCL5 CCL5 JAG1 JAG1 CSF2 CSF2 TRAF3 TRAF3 LIF LIF PIK3CB PIK3CB PIK3R1 PIK3R1 CREB1 CREB1 TRAF1 TRAF1 MAP3K8 MAP3K8 LTA LTA TNF TNF IKBKB IKBKB MAP2K6 MAP2K6 TAB3 TAB3 IL15 IL15 RPS6KA5 RPS6KA5 TRAF5 TRAF5 BIRC3 BIRC3 MAPK10 MAPK10 CASP7 CASP7 CFLAR CFLAR CREB3L4 CREB3L4 RIPK1 RIPK1 ATF2 ATF2 TAB2 TAB2 NOD2 NOD2 EDN1 EDN1 DAB2IP DAB2IP MAPK1 MAPK1 MAPK3 MAPK3 TNFRSF1B TNFRSF1B LOC100345250 LOC100345250 MMP3 MMP3 ITCH ITCH BAG4 BAG4 MAP3K5 MAP3K5 NFKBIA NFKBIA CXCL10 CXCL10 IL18R1 IL18R1 PTGS2 PTGS2 VEGFD VEGFD VEGFC VEGFC CCL2 CCL2 TAB1 TAB1 CEBPB CEBPB IL6 IL6 MAP2K7 MAP2K7 TRADD TRADD MAPK8 MAPK8 CASP10 CASP10 IFNB1 IFNB1 ATF6B ATF6B PIK3CD PIK3CD FOS FOS IL1B IL1B PGAM5 PGAM5 NFKB1 NFKB1 MMP9 MMP9 CSF1 CSF1 PIK3CA PIK3CA ICAM1 ICAM1 MAP2K1 MAP2K1 GRO-B GRO-B MAPK9 MAPK9 CHUK CHUK CREB3 CREB3 FAS FAS MAPK12 MAPK12 CREB5 CREB5 MAP2K4 MAP2K4 CASP3 CASP3 JUN JUN CREB3L2 CREB3L2 AKT3 AKT3 IKBKG IKBKG TNFRSF1A TNFRSF1A MAPK13 MAPK13 IRF1 IRF1 CASP8 CASP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CX3CL1C-X3-C motif chemokine ligand 1. (404 aa)
CCL20C-C motif chemokine. (96 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TNFAIP3TNF alpha induced protein 3. (787 aa)
CCL5C-C motif chemokine. (91 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CSF2Uncharacterized protein. (144 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
TRAF1TNF receptor-associated factor. (415 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (474 aa)
LTALymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (197 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (730 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
BIRC3Baculoviral IAP repeat containing 3. (591 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (303 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (507 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (670 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
NOD2Nucleotide oligomerization domain 2 protein. (1013 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
DAB2IPDAB2 interacting protein. (1178 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
TNFRSF1BTNF receptor superfamily member 1B. (425 aa)
LOC100345250Uncharacterized protein. (461 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
ITCHE3 ubiquitin-protein ligase. (864 aa)
BAG4BCL2 associated athanogene 4. (459 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1316 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CXCL10C-X-C motif chemokine. (98 aa)
IL18R1Uncharacterized protein. (540 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
CEBPBCCAAT enhancer binding protein beta. (353 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
TRADDTNFRSF1A associated via death domain. (447 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (469 aa)
IFNB1Interferon beta 1. (180 aa)
ATF6BActivating transcription factor 6 beta. (622 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
PGAM5PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (294 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
CSF1Colony stimulating factor 1. (535 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ICAM1Intercellular adhesion molecule 1. (534 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
GRO-BPermeability factor 2; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
CREB3cAMP responsive element binding protein 3. (377 aa)
FASUncharacterized protein. (484 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
CREB5cAMP responsive element binding protein 5. (526 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (520 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (584 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
IRF1Interferon regulatory factor. (336 aa)
CASP8DED domain-containing protein. (109 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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