STRINGSTRING
IGHM-3 IGHM-3 LTBR LTBR ITGB7 ITGB7 TNFRSF17 TNFRSF17 ICOS ICOS CXCR4 CXCR4 HLA-DQB2 HLA-DQB2 CD40LG CD40LG IL5 IL5 IL15RA IL15RA LOC100358749 LOC100358749 G1SU40_RABIT G1SU40_RABIT CCR9 CCR9 HLA-DPB1 HLA-DPB1 IL15 IL15 HLA-DRA HLA-DRA CD80 CD80 IL2 IL2 CCL28 CCL28 TNLG7A TNLG7A PIGR PIGR G1TC56_RABIT G1TC56_RABIT HLA-DMA HLA-DMA IL6 IL6 IGHM-2 IGHM-2 TNFSF13 TNFSF13 IL10 IL10 CCR10 CCR10 TNFRSF13B TNFRSF13B RLA-DMB RLA-DMB ITGA4 ITGA4 G1TYN5_RABIT G1TYN5_RABIT AICDA AICDA CD28 CD28 IL4 IL4 MADCAM1 MADCAM1 LOC103345451 LOC103345451 CD40 CD40 CD86 CD86 ENSOCUP00000035377 ENSOCUP00000035377 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000037393 ENSOCUP00000037393 CCL25 CCL25 ENSOCUP00000041377 ENSOCUP00000041377 LOC100349667 LOC100349667 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000046413 ENSOCUP00000046413 HLA-DOB HLA-DOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGHM-3Ig-like domain-containing protein. (167 aa)
LTBRLymphotoxin beta receptor. (414 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
TNFRSF17TNF receptor superfamily member 17. (183 aa)
ICOSInducible T cell costimulator. (222 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (305 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
IL15RASushi domain-containing protein. (262 aa)
LOC100358749Sushi domain-containing protein. (272 aa)
G1SU40_RABITUncharacterized protein. (129 aa)
CCR9C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
HLA-DPB1RLA class II histocompatibility antigen, DP beta chain. (253 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
HLA-DRAIntegral membrane protein; Belongs to the MHC class II family. (255 aa)
CD80T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. (299 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
CCL28SCY domain-containing protein. (130 aa)
TNLG7ATumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (362 aa)
PIGRPolymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. (774 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (234 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
TNFSF13TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (250 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
CCR10C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (362 aa)
TNFRSF13BTNF receptor superfamily member 13B. (276 aa)
RLA-DMBIg-like domain-containing protein. (257 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
G1TYN5_RABITIg-like domain-containing protein. (119 aa)
AICDAActivation induced cytidine deaminase. (198 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
MADCAM1Uncharacterized protein. (344 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CD40Uncharacterized protein. (494 aa)
CD86T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. (336 aa)
ENSOCUP00000035377Ig-like domain-containing protein. (160 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000037393Uncharacterized protein. (92 aa)
CCL25SCY domain-containing protein. (159 aa)
ENSOCUP00000041377Ig-like domain-containing protein. (148 aa)
LOC100349667Ig-like domain-containing protein. (292 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000046413MHC_II_beta domain-containing protein. (169 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (265 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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