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| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa) |
| | LOC100341883 | Protein kinase domain-containing protein. (262 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (399 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (436 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (278 aa) |
| | RAP1B | Uncharacterized protein. (184 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | RAP1A | Uncharacterized protein. (184 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (813 aa) |
| | JUN | BZIP domain-containing protein; Belongs to the bZIP family. (352 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (751 aa) |
| | ABL1 | Tyrosine-protein kinase. (1118 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (539 aa) |
| | MAP2K5 | Mitogen-activated protein kinase kinase 5. (551 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (681 aa) |
| | BDNF | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (265 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | BCL2 | BH4_2 domain-containing protein. (389 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1408 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (416 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (464 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (439 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (534 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa) |
| | MAGED1 | MAGE family member D1. (823 aa) |
| | CDC42-2 | Uncharacterized protein. (222 aa) |
| | SH2B2 | SH2B adaptor protein 2. (625 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | SH2B1 | SH2 domain-containing protein. (337 aa) |
| | PRDM4 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (804 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | LOC100348967 | Uncharacterized protein. (316 aa) |
| | NTF4 | Neurotrophin 4; Belongs to the NGF-beta family. (205 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | CAMK4 | Protein kinase domain-containing protein. (264 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | LOC100346856 | Uncharacterized protein. (316 aa) |
| | LOC100356250 | Uncharacterized protein. (292 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (469 aa) |
| | SHC1 | SHC adaptor protein 1. (474 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1316 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (818 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa) |
| | IRAK3 | Interleukin 1 receptor associated kinase 3. (593 aa) |
| | LOC100345250 | Uncharacterized protein. (461 aa) |
| | MAPKAPK2 | MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] (379 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | CALM1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (823 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | FOXO3 | Fork-head domain-containing protein. (675 aa) |
| | RAC1 | Rac family small GTPase 1. (199 aa) |
| | NTRK2 | Tyrosine-protein kinase receptor. (838 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (798 aa) |
| | IRS1 | Insulin receptor substrate 1. (1220 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa) |
| | ARHGDIB | Rho GDP dissociation inhibitor beta. (200 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | KIDINS220 | Kinase D interacting substrate 220. (1772 aa) |
| | GAB1 | GRB2 associated binding protein 1. (750 aa) |
| | SH2B3 | SH2B adaptor protein 3. (354 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (592 aa) |
| | RPS6KA2 | Non-specific serine/threonine protein kinase. (687 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | ZNF274 | Zinc finger protein 274. (609 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
