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GABRR2 GABRR2 GRIA3 GRIA3 NDUFS4 NDUFS4 ABHD6 ABHD6 GNB4 GNB4 GABRR1 GABRR1 GNAI1 GNAI1 ADCY8 ADCY8 ADCY4 ADCY4 ADCY7 ADCY7 FAAH FAAH GABRB3 GABRB3 GNG8 GNG8 NDUFA2 NDUFA2 NDUFC1 NDUFC1 CACNA1F CACNA1F GNAI3 GNAI3 NDUFS3 NDUFS3 PLCB2 PLCB2 GNG4 GNG4 GRM1 GRM1 GABRQ GABRQ ADCY9 ADCY9 GABRP GABRP NDUFB11 NDUFB11 NDUFAB1 NDUFAB1 GABRA3 GABRA3 ADCY2 ADCY2 GNG3 GNG3 NDUFA7 NDUFA7 GABRE GABRE NDUFV2 NDUFV2 GNB1 GNB1 MAPK10 MAPK10 NDUFB3 NDUFB3 GABRG3 GABRG3 GNB5 GNB5 NDUFS1 NDUFS1 CACNA1B CACNA1B SLC17A7 SLC17A7 GRM5 GRM5 GABRA5 GABRA5 GNB3 GNB3 CACNA1D CACNA1D NDUFS2 NDUFS2 MAPK1 MAPK1 MAPK3 MAPK3 GABRA6 GABRA6 ADCY5 ADCY5 NDUFA6 NDUFA6 ADCY3 ADCY3 GNGT2 GNGT2 SLC17A6 SLC17A6 GNAQ GNAQ PTGS2 PTGS2 GNG11 GNG11 GNGT1 GNGT1 NDUFB5 NDUFB5 GRIA2 GRIA2 GABRR3 GABRR3 KCNJ6 KCNJ6 GNG14 GNG14 GABRG1 GABRG1 NDUFA9 NDUFA9 MAPK8 MAPK8 GNAI2 GNAI2 KCNJ3 KCNJ3 GNG12 GNG12 NAPEPLD NAPEPLD NDUFS5 NDUFS5 GABRA4 GABRA4 NDUFA3 NDUFA3 NDUFA4L2 NDUFA4L2 CACNA1S CACNA1S NDUFB2 NDUFB2 GABRB1 GABRB1 ND1 ND1 ND2 ND2 ND3 ND3 ND4L ND4L ND4 ND4 ND5 ND5 ND6 ND6 SLC32A1 SLC32A1 NDUFB4 NDUFB4 NDUFA4 NDUFA4 ALG8-2 ALG8-2 NDUFA5 NDUFA5 ITPR1 ITPR1 GABRD GABRD MAPK9 MAPK9 DAGLB DAGLB NDUFA8 NDUFA8 MAPK12 MAPK12 SLC17A8 SLC17A8 MGLL MGLL PLCB1 PLCB1 NDUFA12 NDUFA12 DAGLA DAGLA ITPR3 ITPR3 NDUFS6 NDUFS6 GRIA1 GRIA1 GABRB2 GABRB2 ADCY6 ADCY6 GRIA4 GRIA4 NDUFA10 NDUFA10 NDUFB1 NDUFB1 ITPR2 ITPR2 KCNJ9 KCNJ9 GNB2 GNB2 NDUFB8 NDUFB8 PRKACB PRKACB PRKCB PRKCB MAPK13 MAPK13 KCNJ5 KCNJ5 GABRA1 GABRA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GABRR2Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (241 aa)
ABHD6Abhydrolase domain containing 6. (399 aa)
GNB4G protein subunit beta 4. (405 aa)
GABRR1Gamma-aminobutyric acid type A receptor rho1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (479 aa)
GNAI1G protein subunit alpha i1. (349 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
FAAHFatty acid amide hydrolase. (595 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (471 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
NDUFA2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (99 aa)
NDUFC1NADH:ubiquinone oxidoreductase subunit C1. (128 aa)
CACNA1FCalcium voltage-gated channel subunit alpha1 F. (1734 aa)
GNAI3G protein subunit alpha i3. (354 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (263 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (197 aa)
GRM1Glutamate metabotropic receptor 1. (1203 aa)
GABRQGamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (610 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1236 aa)
GABRPGamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (440 aa)
NDUFB11NADH:ubiquinone oxidoreductase subunit B11. (154 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa)
GABRA3Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (496 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1040 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NDUFA7Uncharacterized protein. (113 aa)
GABREGamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (507 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (249 aa)
GNB1G protein subunit beta 1. (340 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NDUFB3NADH:ubiquinone oxidoreductase subunit B3. (102 aa)
GABRG3Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (460 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] (372 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family. (727 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha-1B; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin- GVIA (AC P01522) (By similarity). They are however insen [...] (2197 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
GRM5Glutamate metabotropic receptor 5. (988 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
GNB3G protein subunit beta 3. (340 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2141 aa)
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (463 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
GABRA6Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (453 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1010 aa)
NDUFA6NADH:ubiquinone oxidoreductase subunit A6; Belongs to the complex I LYR family. (155 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
GNAQG protein subunit alpha q. (325 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (189 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GABRR3Gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (468 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GABRG1Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (377 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GNAI2G protein subunit alpha i2. (355 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
NAPEPLDN-acyl phosphatidylethanolamine phospholipase D. (394 aa)
NDUFS5NADH:ubiquinone oxidoreductase subunit S5. (106 aa)
GABRA4Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (517 aa)
NDUFA3NADH:ubiquinone oxidoreductase subunit A3. (84 aa)
NDUFA4L2NDUFA4 mitochondrial complex associated like 2. (87 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. (1828 aa)
NDUFB2NADH:ubiquinone oxidoreductase subunit B2. (100 aa)
GABRB1Neur_chan_memb domain-containing protein. (182 aa)
ND1NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (318 aa)
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa)
ND3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (115 aa)
ND4LNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (98 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (459 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (603 aa)
ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (174 aa)
SLC32A1Solute carrier family 32 member 1. (394 aa)
NDUFB4Uncharacterized protein. (153 aa)
NDUFA4Uncharacterized protein. (82 aa)
ALG8-2NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (120 aa)
NDUFA5Uncharacterized protein. (142 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2756 aa)
GABRDUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (694 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
DAGLBDiacylglycerol lipase beta. (618 aa)
NDUFA8NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (188 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
SLC17A8Solute carrier family 17 member 8. (610 aa)
MGLLUncharacterized protein. (190 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
NDUFA12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (145 aa)
DAGLADiacylglycerol lipase alpha. (1028 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2616 aa)
NDUFS6zf-CHCC domain-containing protein. (225 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (915 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
NDUFA10dNK domain-containing protein. (444 aa)
NDUFB1Uncharacterized protein. (58 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2735 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (283 aa)
GNB2G protein subunit beta 2. (455 aa)
NDUFB8Uncharacterized protein. (219 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PRKCBProtein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (463 aa)
GABRA1Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (470 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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