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GRIK2 GRIK2 GLUL GLUL GNG3 GNG3 HOMER1 HOMER1 GNB1 GNB1 GNB5 GNB5 PLA2G4B PLA2G4B SLC17A7 SLC17A7 GRM5 GRM5 GNB3 GNB3 SLC1A6 SLC1A6 CACNA1D CACNA1D MAPK1 MAPK1 MAPK3 MAPK3 PLA2G4D PLA2G4D PLD1 PLD1 PLA2G4A PLA2G4A PLA2G4C PLA2G4C GRIN2B GRIN2B ADCY5 ADCY5 ADCY3 ADCY3 GNGT2 GNGT2 SLC17A6 SLC17A6 GNAQ GNAQ GRM6 GRM6 GNG11 GNG11 GNGT1 GNGT1 GRM7 GRM7 GRM2 GRM2 TRPC1 TRPC1 LOC100346323 LOC100346323 GRIA2 GRIA2 GNG14 GNG14 GNAI2 GNAI2 PPP3CB PPP3CB KCNJ3 KCNJ3 GNG12 GNG12 GRIN2C GRIN2C GRK3 GRK3 SLC1A1 SLC1A1 SLC1A3 SLC1A3 GRIN3A GRIN3A DLGAP1 DLGAP1 PPP3CC PPP3CC SLC38A3 SLC38A3 SLC38A2 SLC38A2 LOC100359182 LOC100359182 ITPR1 ITPR1 PLA2G4E PLA2G4E GRIK1 GRIK1 SLC17A8 SLC17A8 PLA2G4F PLA2G4F GRIN2A GRIN2A PLCB1 PLCB1 ITPR3 ITPR3 GRIA1 GRIA1 ADCY6 ADCY6 GRM8 GRM8 GRIA4 GRIA4 ITPR2 ITPR2 GNB2 GNB2 PRKACB PRKACB LOC103350182 LOC103350182 PPP3CA PPP3CA PRKCB PRKCB HOMER2 HOMER2 DLG4 DLG4 SHANK2 SHANK2 GNAS GNAS GRIA3 GRIA3 SLC1A2 SLC1A2 GNB4 GNB4 GNAI1 GNAI1 GLS GLS GRM4 GRM4 SLC1A7 SLC1A7 ADCY8 ADCY8 GRIK4 GRIK4 ADCY4 ADCY4 ADCY7 ADCY7 GNG8 GNG8 GNAI3 GNAI3 GRIK3 GRIK3 PLCB2 PLCB2 GNG4 GNG4 GRM1 GRM1 GRM3 GRM3 ADCY9 ADCY9 ADCY2 ADCY2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
GLULGlutamine synthetase. (373 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
HOMER1Homer scaffold protein 1. (354 aa)
GNB1G protein subunit beta 1. (340 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] (372 aa)
PLA2G4BPhospholipase A2. (779 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
GRM5Glutamate metabotropic receptor 5. (988 aa)
GNB3G protein subunit beta 3. (340 aa)
SLC1A6Amino acid transporter. (564 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2141 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
PLA2G4DPhospholipase A2. (825 aa)
PLD1Phospholipase. (1031 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (748 aa)
PLA2G4CPLA2c domain-containing protein. (829 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1010 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
GNAQG protein subunit alpha q. (325 aa)
GRM6Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. (867 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GRM7Glutamate metabotropic receptor 7. (677 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
TRPC1Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. (793 aa)
LOC100346323Uncharacterized protein. (240 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PPP3CBSerine/threonine-protein phosphatase. (518 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GRIN2CUncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (671 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
SLC1A1Excitatory amino acid transporter 3; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine (By similarity). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspar [...] (524 aa)
SLC1A3Amino acid transporter. (542 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
DLGAP1DLG associated protein 1. (987 aa)
PPP3CCSerine/threonine-protein phosphatase. (574 aa)
SLC38A3Solute carrier family 38 member 3. (521 aa)
SLC38A2Solute carrier family 38 member 2. (563 aa)
LOC100359182Amino acid transporter. (665 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2756 aa)
PLA2G4EPhospholipase A2. (854 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (949 aa)
SLC17A8Solute carrier family 17 member 8. (610 aa)
PLA2G4FPhospholipase A2. (897 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1087 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2616 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (915 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2735 aa)
GNB2G protein subunit beta 2. (455 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
LOC103350182Amino acid transporter. (162 aa)
PPP3CASerine/threonine-protein phosphatase. (695 aa)
PRKCBProtein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
HOMER2Homer scaffold protein 2. (375 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1891 aa)
GNASGNAS complex locus. (977 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
SLC1A2Amino acid transporter. (579 aa)
GNB4G protein subunit beta 4. (405 aa)
GNAI1G protein subunit alpha i1. (349 aa)
GLSGlutaminase. (784 aa)
GRM4Glutamate metabotropic receptor 4. (1050 aa)
SLC1A7Amino acid transporter. (159 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (880 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (197 aa)
GRM1Glutamate metabotropic receptor 1. (1203 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1236 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1040 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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