STRINGSTRING
AKT3 AKT3 ITPR2 ITPR2 GNB2 GNB2 PRKACB PRKACB IRK2 IRK2 PRKCB PRKCB CHRM4 CHRM4 PIK3R6 PIK3R6 GNB4 GNB4 GNAI1 GNAI1 SLC5A7 SLC5A7 CHRNA7 CHRNA7 ADCY8 ADCY8 ADCY4 ADCY4 ADCY7 ADCY7 GNG8 GNG8 PIK3CB PIK3CB CHRNA3 CHRNA3 PIK3R1 PIK3R1 CACNA1F CACNA1F CREB1 CREB1 GNAI3 GNAI3 PLCB2 PLCB2 GNG4 GNG4 ADCY9 ADCY9 ADCY2 ADCY2 KCNJ14 KCNJ14 GNG3 GNG3 GNB1 GNB1 KCNJ4 KCNJ4 KCNJ2 KCNJ2 CREB3L4 CREB3L4 GNB5 GNB5 KCNQ3 KCNQ3 KRAS KRAS CACNA1B CACNA1B PIK3CG PIK3CG GNB3 GNB3 CACNA1D CACNA1D MAPK1 MAPK1 MAPK3 MAPK3 LOC100345250 LOC100345250 ADCY5 ADCY5 ADCY3 ADCY3 FYN FYN KCNQ4 KCNQ4 GNGT2 GNGT2 GNAQ GNAQ CHRM2 CHRM2 JAK2 JAK2 GNG11 GNG11 GNGT1 GNGT1 CAMK2A CAMK2A CHAT CHAT KCNJ6 KCNJ6 GNG14 GNG14 CAMK4 CAMK4 NRAS NRAS GNAI2 GNAI2 SLC18A3 SLC18A3 KCNJ3 KCNJ3 GNG12 GNG12 PIK3CD PIK3CD CHRM5 CHRM5 FOS FOS PIK3R5 PIK3R5 CACNA1S CACNA1S CHRM3 CHRM3 PIK3CA PIK3CA MAP2K1 MAP2K1 ITPR1 ITPR1 KCNQ5 KCNQ5 CREB3 CREB3 CREB5 CREB5 CHRNA4 CHRNA4 CHRNA6 CHRNA6 BCL2 BCL2 PLCB1 PLCB1 ITPR3 ITPR3 KCNQ1 KCNQ1 CREB3L2 CREB3L2 ADCY6 ADCY6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase. (511 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2735 aa)
GNB2G protein subunit beta 2. (455 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
IRK2Uncharacterized protein. (398 aa)
PRKCBProtein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (777 aa)
GNB4G protein subunit beta 4. (405 aa)
GNAI1G protein subunit alpha i1. (349 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
CHRNA7Uncharacterized protein. (513 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (500 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CACNA1FCalcium voltage-gated channel subunit alpha1 F. (1734 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (197 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1236 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1040 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (434 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNB1G protein subunit beta 1. (340 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (442 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] (372 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (809 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha-1B; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin- GVIA (AC P01522) (By similarity). They are however insen [...] (2197 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
GNB3G protein subunit beta 3. (340 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2141 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
LOC100345250Uncharacterized protein. (461 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1010 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
FYNTyrosine-protein kinase. (537 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (629 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
GNAQG protein subunit alpha q. (325 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (520 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (469 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (634 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (423 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CAMK4Protein kinase domain-containing protein. (264 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI2G protein subunit alpha i2. (355 aa)
SLC18A3Solute carrier family 18 member A3. (532 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (880 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. (1828 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (599 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2756 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (951 aa)
CREB3cAMP responsive element binding protein 3. (377 aa)
CREB5cAMP responsive element binding protein 5. (526 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (542 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2616 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (695 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (584 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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