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| | DOCK1 | Dedicator of cytokinesis 1; Belongs to the DOCK family. (1886 aa) |
| | FGD1 | FYVE, RhoGEF and PH domain containing 1. (950 aa) |
| | MSN | FERM domain-containing protein. (577 aa) |
| | PDGFRA | Protein kinase domain-containing protein. (773 aa) |
| | ITGA6 | Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (955 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa) |
| | MYL9 | Myosin light chain 9. (172 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (284 aa) |
| | PFN1 | Profilin; Belongs to the profilin family. (104 aa) |
| | ITGB7 | Integrin beta; Belongs to the integrin beta chain family. (798 aa) |
| | GNA12 | G protein subunit alpha 12. (457 aa) |
| | DIAPH3 | Diaphanous related formin 3. (1191 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa) |
| | CXCR4 | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | PIKFYVE | Phosphoinositide kinase, FYVE-type zinc finger containing. (2074 aa) |
| | ARPC5L | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa) |
| | ITGA10 | Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1169 aa) |
| | ITGA2B | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1008 aa) |
| | IQGAP3 | IQ motif containing GTPase activating protein 3. (1720 aa) |
| | ITGB1 | Integrin beta; Belongs to the integrin beta chain family. (830 aa) |
| | FGF19 | Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (218 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | ARPC2 | Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (322 aa) |
| | PDGFA | Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] (150 aa) |
| | MRAS | Muscle RAS oncogene homolog. (208 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa) |
| | PFN2 | Profilin; Belongs to the profilin family. (91 aa) |
| | DIAPH2 | Diaphanous related formin 2. (1052 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | GNA13 | G protein subunit alpha 13. (377 aa) |
| | WASF1 | WASP family member 1. (352 aa) |
| | PAK2 | Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...] (524 aa) |
| | WASL | WASP like actin nucleation promoting factor. (512 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (337 aa) |
| | CFL2 | Cofilin 2; Belongs to the actin-binding proteins ADF family. (195 aa) |
| | RAC1 | Rac family small GTPase 1. (199 aa) |
| | SPATA13 | Uncharacterized protein. (1334 aa) |
| | FN1 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2427 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1193 aa) |
| | INSRR | Tyrosine-protein kinase receptor. (1320 aa) |
| | CYFIP1 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1272 aa) |
| | PAK5 | Non-specific serine/threonine protein kinase. (719 aa) |
| | ITGA1 | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1178 aa) |
| | ARPC3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa) |
| | SSH1 | Slingshot protein phosphatase 1. (1196 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1181 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | LOC100345250 | Uncharacterized protein. (461 aa) |
| | ITGAL | Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1241 aa) |
| | ITGB5 | Integrin beta; Belongs to the integrin beta chain family. (799 aa) |
| | MYL12A | Myosin light chain 12A. (172 aa) |
| | BDKRB2 | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. (446 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (563 aa) |
| | PDGFD | Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). (538 aa) |
| | APC | APC regulator of WNT signaling pathway. (2871 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (406 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1592 aa) |
| | CHRM2 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (520 aa) |
| | GIT1 | GIT ArfGAP 1. (753 aa) |
| | ARHGAP35 | Rho GTPase activating protein 35. (1415 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa) |
| | ITGAX | Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1060 aa) |
| | ITGA11 | Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1151 aa) |
| | MYLPF | Myosin regulatory light chain 2, skeletal muscle isoform type 2. (200 aa) |
| | LOC100356250 | Uncharacterized protein. (292 aa) |
| | LOC100346856 | Uncharacterized protein. (316 aa) |
| | GNG14 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa) |
| | LPAR5 | Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (369 aa) |
| | WASF2 | WASP family member 2. (496 aa) |
| | BAIAP2 | IMD domain-containing protein. (322 aa) |
| | LOC100356070 | Profilin; Belongs to the profilin family. (153 aa) |
| | MOS | MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (348 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa) |
| | F2R | Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (460 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa) |
| | LOC100348967 | Uncharacterized protein. (316 aa) |
| | MYL10 | Myosin light chain 10. (167 aa) |
| | ACTN4 | Actinin alpha 4. (653 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | CHRM5 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa) |
| | LIMK1 | LIM domain kinase 1. (645 aa) |
| | BDKRB1 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. (497 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa) |
| | PAK6 | Non-specific serine/threonine protein kinase. (681 aa) |
| | CHRM3 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (599 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase. (263 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa) |
| | MYH11 | Myosin-11; Muscle contraction. (1944 aa) |
| | ARPC4 | Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (187 aa) |
| | CDC42-2 | Uncharacterized protein. (222 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | IQGAP1 | IQ motif containing GTPase activating protein 1. (1727 aa) |
| | ITGA9 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (597 aa) |
| | LIMK2 | LIM domain kinase 2. (693 aa) |
| | PDGFB | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1258 aa) |
| | MYL2 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] (232 aa) |
| | BRK1 | BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa) |
| | ARPC1A | Actin related protein 2/3 complex subunit 1A. (508 aa) |
| | ITGA7 | Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
| | ITGB6 | Integrin beta; Belongs to the integrin beta chain family. (787 aa) |
| | ITGA2 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa) |
| | PAK4 | P21 (RAC1) activated kinase 4. (726 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (612 aa) |
| | NCKAP1 | NCK associated protein 1. (1134 aa) |
| | KNG1 | Kininogen 1. (633 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (873 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain containing 3. (724 aa) |
| | FGF18 | Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (801 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (894 aa) |
| | ROCK1 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] (1352 aa) |
| | RRAS2 | RAS related 2. (225 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (964 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (585 aa) |
| | BCAR1 | BCAR1 scaffold protein, Cas family member. (869 aa) |
| | RDX | Radixin. (643 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | MYH10 | Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa) |
| | PTK2-2 | FERM_N_2 domain-containing protein. (121 aa) |
| | FGFR4 | Fibroblast growth factor receptor. (862 aa) |
| | VCL | Vinculin. (1241 aa) |
| | DIAPH1 | DAD domain-containing protein. (74 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa) |
| | ACTN1 | Actinin alpha 1. (1038 aa) |
| | EZR | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (653 aa) |
| | ITGB2 | Integrin beta. (1009 aa) |
| | FGF17 | Uncharacterized protein; Belongs to the heparin-binding growth factors family. (151 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (823 aa) |
| | CYFIP2 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | ITGAE | Integrin subunit alpha E; Belongs to the integrin alpha chain family. (1182 aa) |
| | PFN4 | Uncharacterized protein; Belongs to the profilin family. (201 aa) |
| | GSN | Gelsolin. (828 aa) |
| | ITGB8 | Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity). (772 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (435 aa) |
| | MYLK4 | Protein kinase domain-containing protein. (706 aa) |
| | ACTB | Uncharacterized protein. (357 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (358 aa) |
| | ITGA8 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa) |
| | SSH2 | Slingshot protein phosphatase 2. (1446 aa) |
| | LPAR1 | Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa) |
| | PAK3 | Non-specific serine/threonine protein kinase. (652 aa) |
| | CHRM4 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa) |
