STRINGSTRING
CPT1B CPT1B AGRP AGRP PRKAB2 PRKAB2 MAPK10 MAPK10 LEP LEP ACSBG2 ACSBG2 ACACB ACACB IRS1 IRS1 IKBKB IKBKB TNF TNF PRKAG2 PRKAG2 ACSL1 ACSL1 NFKB1 NFKB1 ACSBG1 ACSBG1 ACSL6 ACSL6 ACSL5 ACSL5 U3KM51_RABIT U3KM51_RABIT NPY NPY SLC2A1 SLC2A1 PRKAB1 PRKAB1 ADIPOR2 ADIPOR2 PRKAG1 PRKAG1 LOC100339305 LOC100339305 MAPK9 MAPK9 CHUK CHUK G6PC3 G6PC3 STAT3 STAT3 IRS4 IRS4 PRKAA2 PRKAA2 PTPN11 PTPN11 PRKAG3 PRKAG3 PCK2 PCK2 CD36 CD36 G6PC2 G6PC2 PRKAA1 PRKAA1 ACSL3 ACSL3 ACSL4 ACSL4 PPARGC1A PPARGC1A POMC POMC AKT3 AKT3 IKBKG IKBKG TNFRSF1A TNFRSF1A MTOR MTOR TNFRSF1B TNFRSF1B LOC100350716 LOC100350716 NFKBIA NFKBIA G6PC G6PC JAK2 JAK2 LEPR LEPR PCK1 PCK1 RXRB RXRB NFKBIB NFKBIB TRADD TRADD MAPK8 MAPK8 ADIPOQ ADIPOQ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (495 aa)
AGRPAgouti related neuropeptide. (132 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ACSBG2Acyl-CoA synthetase bubblegum family member 2. (686 aa)
ACACBAcetyl-CoA carboxylase beta. (2373 aa)
IRS1Insulin receptor substrate 1. (1220 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (543 aa)
ACSL1Uncharacterized protein. (198 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (711 aa)
ACSL6AMP-binding domain-containing protein. (722 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (726 aa)
U3KM51_RABITUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (794 aa)
NPYNeuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. (97 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (512 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ADIPOR2Adiponectin receptor 2. (486 aa)
PRKAG1Uncharacterized protein. (378 aa)
LOC100339305Uncharacterized protein. (506 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
G6PC3Glucose-6-phosphatase catalytic subunit 3. (562 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IRS4Insulin receptor substrate 4. (1176 aa)
PRKAA2Non-specific serine/threonine protein kinase. (537 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (484 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKAA1Non-specific serine/threonine protein kinase. (656 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (782 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
PPARGC1APPARG coactivator 1 alpha. (860 aa)
POMCNPP domain-containing protein. (285 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
TNFRSF1BTNF receptor superfamily member 1B. (425 aa)
LOC100350716Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (808 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
G6PCGlucose-6-phosphatase catalytic subunit. (359 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LEPRLeptin receptor. (1164 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
RXRBRetinoid X receptor beta. (541 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
TRADDTNFRSF1A associated via death domain. (447 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ADIPOQC1q domain-containing protein. (244 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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