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GNG4 GNG4 COL4A3 COL4A3 GNB4 GNB4 GNAI1 GNAI1 NOS2 NOS2 MMP13 MMP13 ADCY8 ADCY8 ADCY4 ADCY4 ADCY7 ADCY7 GNG8 GNG8 INSL5 INSL5 PIK3CB PIK3CB RXFP3 RXFP3 PIK3R1 PIK3R1 CREB1 CREB1 GNAI3 GNAI3 SOS2 SOS2 SHC4 SHC4 PLCB2 PLCB2 COL4A4 COL4A4 ADCY9 ADCY9 ACTA2 ACTA2 ADCY2 ADCY2 GNG3 GNG3 GNB1 GNB1 EGFR EGFR MAPK10 MAPK10 SMAD2 SMAD2 VEGFA VEGFA CREB3L4 CREB3L4 GNB5 GNB5 KRAS KRAS ATF2 ATF2 COL1A2 COL1A2 COL1A1 COL1A1 GNB3 GNB3 COL4A1 COL4A1 EDN1 EDN1 RLN3 RLN3 MAPK1 MAPK1 MAPK3 MAPK3 LOC100345250 LOC100345250 COL3A1 COL3A1 ADCY5 ADCY5 ADCY3 ADCY3 NFKBIA NFKBIA SHC1 SHC1 GNGT2 GNGT2 G1TC56_RABIT G1TC56_RABIT GNG11 GNG11 GNGT1 GNGT1 VEGFD VEGFD EDNRB EDNRB VEGFC VEGFC LOC100346323 LOC100346323 GNG14 GNG14 MAP2K7 MAP2K7 MAPK8 MAPK8 NRAS NRAS GNAI2 GNAI2 SOS1 SOS1 GNG12 GNG12 ATF6B ATF6B PIK3CD PIK3CD FOS FOS RXFP4 RXFP4 COL4A5 COL4A5 NFKB1 NFKB1 RELH_RABIT RELH_RABIT MMP9 MMP9 NOS3 NOS3 PIK3CA PIK3CA MAP2K1 MAP2K1 LOC108178086 LOC108178086 MAPK9 MAPK9 LOC103345451 LOC103345451 CREB3 CREB3 MAPK12 MAPK12 CREB5 CREB5 MAP2K4 MAP2K4 TGFBR1 TGFBR1 MMP1 MMP1 PLCB1 PLCB1 RAF1 RAF1 ENSOCUP00000037329 ENSOCUP00000037329 JUN JUN CREB3L2 CREB3L2 ADCY6 ADCY6 AKT3 AKT3 GRB2 GRB2 GNB2 GNB2 PRKACB PRKACB ENSOCUP00000044284 ENSOCUP00000044284 COL4A6 COL4A6 MAPK13 MAPK13 RXFP2 RXFP2 GNAS GNAS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (197 aa)
COL4A3Collagen type IV alpha 3 chain. (1494 aa)
GNB4G protein subunit beta 4. (405 aa)
GNAI1G protein subunit alpha i1. (349 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1146 aa)
MMP13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
INSL5Insulin-like 5. (136 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RXFP3G_PROTEIN_RECEP_F1_2 domain-containing protein. (465 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNAI3G protein subunit alpha i3. (354 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa)
SHC4SHC adaptor protein 4. (630 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa)
COL4A4Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1687 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1236 aa)
ACTA2Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (471 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1040 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNB1G protein subunit beta 1. (340 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] (372 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1364 aa)
COL1A1Collagen alpha-1(I) chain. (1348 aa)
GNB3G protein subunit beta 3. (340 aa)
COL4A1Collagen type IV alpha 1 chain. (1637 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
RLN3Relaxin 3. (172 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
LOC100345250Uncharacterized protein. (461 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1010 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
SHC1SHC adaptor protein 1. (474 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (441 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
LOC100346323Uncharacterized protein. (240 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNAI2G protein subunit alpha i2. (355 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ATF6BActivating transcription factor 6 beta. (622 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
RXFP4G_PROTEIN_RECEP_F1_2 domain-containing protein. (373 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
RELH_RABITRelaxin-like protein SQ10 A chain. (178 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
LOC108178086Uncharacterized protein. (144 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CREB3cAMP responsive element binding protein 3. (377 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
CREB5cAMP responsive element binding protein 5. (526 aa)
MAP2K4Mitogen-activated protein kinase kinase 4. (520 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
MMP1Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (584 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
GNB2G protein subunit beta 2. (455 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
COL4A6Collagen type IV alpha 6 chain. (1780 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
RXFP2Relaxin family peptide receptor 2. (745 aa)
GNASGNAS complex locus. (977 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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