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| | GYS2 | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (705 aa) |
| | GYS1 | Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (735 aa) |
| | PPP1R3A | Protein phosphatase 1 regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). (1109 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (477 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (656 aa) |
| | G6PC2 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa) |
| | NR1H3 | Liver X receptor alpha. (447 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa) |
| | PYGM | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (829 aa) |
| | CD36 | CD36 molecule; Belongs to the CD36 family. (472 aa) |
| | RPS6KA2 | Non-specific serine/threonine protein kinase. (687 aa) |
| | OGA | O-GlcNAcase. (916 aa) |
| | PYGB | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (831 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (484 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | SLC2A2 | Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (521 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (537 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (543 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | IRS1 | Insulin receptor substrate 1. (1220 aa) |
| | ACACB | Acetyl-CoA carboxylase beta. (2373 aa) |
| | PTPN1 | Protein tyrosine phosphatase non-receptor type 1. (495 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase. (263 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | U3KM51_RABIT | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (794 aa) |
| | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (512 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | SLC27A4 | Solute carrier family 27 member 4. (736 aa) |
| | TBC1D4 | TBC1 domain family member 4. (1297 aa) |
| | PTPRF | Protein tyrosine phosphatase receptor type F. (1956 aa) |
| | PRKAG1 | Uncharacterized protein. (378 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (439 aa) |
| | G6PC3 | Glucose-6-phosphatase catalytic subunit 3. (562 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (377 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (860 aa) |
| | CREB5 | cAMP responsive element binding protein 5. (526 aa) |
| | GFPT2 | Glutamine-fructose-6-phosphate transaminase 2. (737 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (751 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (584 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (813 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1377 aa) |
| | PPARGC1B | PPARG coactivator 1 beta. (1125 aa) |
| | OGT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue. Acts on cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosyla [...] (1049 aa) |
| | PTPA | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...] (597 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (472 aa) |
| | CPT1B | Carnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (495 aa) |
| | PRKAB2 | Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (358 aa) |
| | PRKCB | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa) |
| | LOC100341883 | Protein kinase domain-containing protein. (262 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] (337 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | MLXIP | MLX interacting protein. (925 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (395 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa) |
| | LOC100345250 | Uncharacterized protein. (461 aa) |
| | FOXO1 | Fork-head domain-containing protein. (613 aa) |
| | PPP1R3C | Protein phosphatase 1 regulatory subunit 3C. (439 aa) |
| | LOC100350716 | Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (808 aa) |
| | PYGL | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | CRTC2 | CREB regulated transcription coactivator 2. (652 aa) |
| | G6PC | Glucose-6-phosphatase catalytic subunit. (359 aa) |
| | SLC27A2 | Solute carrier family 27 member 2. (620 aa) |
| | SLC27A6 | Solute carrier family 27 member 6. (619 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | PPP1R3E | Protein phosphatase 1 regulatory subunit 3E. (279 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (505 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa) |
| | PPP1R3B | Protein phosphatase 1 regulatory subunit. (285 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
