STRINGSTRING
TGFBR1 TGFBR1 BCL2 BCL2 PLCB1 PLCB1 CASP3 CASP3 ENSOCUP00000037329 ENSOCUP00000037329 PLCD4 PLCD4 DIAPH1 DIAPH1 STAT1 STAT1 JUN JUN AKT3 AKT3 NOX4 NOX4 ENSOCUP00000044284 ENSOCUP00000044284 COL4A6 COL4A6 MAPK13 MAPK13 PRKCB PRKCB COL4A3 COL4A3 AGT AGT PLCE1 PLCE1 SMAD4 SMAD4 PIK3CB PIK3CB STAT5B STAT5B PIK3R1 PIK3R1 TGFB2 TGFB2 NOX1 NOX1 BAX BAX NFATC1 NFATC1 PLCB2 PLCB2 TNF TNF COL4A4 COL4A4 EGR1 EGR1 IL1A IL1A RAC1 RAC1 FN1 FN1 MAPK10 MAPK10 STAT3 STAT3 SMAD2 SMAD2 TGFB3 TGFB3 VEGFA VEGFA PIM1 PIM1 KRAS KRAS COL1A2 COL1A2 CDK4 CDK4 COL1A1 COL1A1 PLCG2 PLCG2 COL4A1 COL4A1 EDN1 EDN1 MAPK1 MAPK1 MAPK3 MAPK3 PRKCE PRKCE CDKN1B CDKN1B LOC100345250 LOC100345250 FOXO1 FOXO1 COL3A1 COL3A1 G1TC56_RABIT G1TC56_RABIT JAK2 JAK2 PLCD3 PLCD3 VEGFD VEGFD VEGFC VEGFC CCL2 CCL2 AGER AGER IL6 IL6 CXCL8 CXCL8 MAPK8 MAPK8 NRAS NRAS PIK3CD PIK3CD PLCG1 PLCG1 IL1B IL1B COL4A5 COL4A5 NFKB1 NFKB1 STAT5A STAT5A NOS3 NOS3 CDC42-2 CDC42-2 PIK3CA PIK3CA ICAM1 ICAM1 SMAD3 SMAD3 AGTR1 AGTR1 F3 F3 MAPK9 MAPK9 LOC103345451 LOC103345451 MAPK12 MAPK12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
PLCD4Phosphoinositide phospholipase C. (789 aa)
DIAPH1DAD domain-containing protein. (74 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
NOX4NADPH oxidase 4. (638 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
COL4A6Collagen type IV alpha 6 chain. (1780 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
PRKCBProtein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
COL4A3Collagen type IV alpha 3 chain. (1494 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
PLCE1Phosphoinositide phospholipase C. (2300 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NOX1NADPH oxidase 1. (564 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
NFATC1RHD domain-containing protein. (672 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
COL4A4Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1687 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (700 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
RAC1Rac family small GTPase 1. (199 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2427 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1364 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa)
COL1A1Collagen alpha-1(I) chain. (1348 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
COL4A1Collagen type IV alpha 1 chain. (1637 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LOC100345250Uncharacterized protein. (461 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
PLCD3Phosphoinositide phospholipase C. (783 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
AGERAdvanced glycosylation end-product specific receptor. (401 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1209 aa)
CDC42-2Uncharacterized protein. (222 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ICAM1Intercellular adhesion molecule 1. (534 aa)
SMAD3SMAD family member 3. (230 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (425 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (397 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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