STRINGSTRING
CALML5 CALML5 RHOA RHOA ITGA5 ITGA5 MAPK1 MAPK1 MAPK3 MAPK3 C4BPA C4BPA C1S C1S IL12B IL12B LOC100356250 LOC100356250 TICAM2 TICAM2 LOC100346856 LOC100346856 IL6 IL6 CXCL8 CXCL8 MAPK8 MAPK8 G1TPZ5_RABIT G1TPZ5_RABIT IL10 IL10 GNAI2 GNAI2 LOC100348967 LOC100348967 FOS FOS IL1B IL1B NFKB1 NFKB1 TRAF6 TRAF6 ITGAM ITGAM IRAK1 IRAK1 MAPK9 MAPK9 IRAK4 IRAK4 TIRAP TIRAP SFTPA1 SFTPA1 MAPK12 MAPK12 MYD88 MYD88 CASP3 CASP3 ITGB2 ITGB2 MAPK13 MAPK13 JUN JUN IRF8 IRF8 GNAI1 GNAI1 CASP1 CASP1 NOS2 NOS2 TLR4 TLR4 ITGB1 ITGB1 CD14 CD14 PYCARD PYCARD NOD1 NOD1 NLRP3 NLRP3 GNAI3 GNAI3 C5 C5 TNF TNF C2 C2 C4A C4A IL23A IL23A IL1A IL1A CFL2 CFL2 IRF1 IRF1 MAPK10 MAPK10 CASP7 CASP7 CALM1 CALM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALML5Calmodulin like 5. (149 aa)
RHOARas homolog family member A. (193 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
C4BPAComplement component 4 binding protein alpha. (635 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (690 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
LOC100356250Uncharacterized protein. (292 aa)
TICAM2TIR domain-containing protein. (241 aa)
LOC100346856Uncharacterized protein. (316 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
G1TPZ5_RABITUncharacterized protein. (551 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
GNAI2G protein subunit alpha i2. (355 aa)
LOC100348967Uncharacterized protein. (316 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1258 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (464 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
SFTPA1Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. (416 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
MYD88Uncharacterized protein. (476 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
ITGB2Integrin beta. (1009 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
IRF8Interferon regulatory factor 8. (455 aa)
GNAI1G protein subunit alpha i1. (349 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1146 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (830 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
PYCARDPYD and CARD domain containing. (196 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
NLRP3NLR family pyrin domain containing 3. (1046 aa)
GNAI3G protein subunit alpha i3. (354 aa)
C5Complement C5. (1678 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
C2Complement C2; Belongs to the peptidase S1 family. (744 aa)
C4AUncharacterized protein. (1743 aa)
IL23AInterleukin 23 subunit alpha. (191 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (195 aa)
IRF1Interferon regulatory factor. (336 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (303 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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