STRINGSTRING
IL10 IL10 NCF4 NCF4 FOS FOS IL1B IL1B RLA-DMB RLA-DMB ITGA4 ITGA4 G1TYN5_RABIT G1TYN5_RABIT NFKB1 NFKB1 IL4 IL4 IGHM-3 IGHM-3 IFNGR2 IFNGR2 TRAF6 TRAF6 LOC100337909 LOC100337909 ITGAM ITGAM IRAK1 IRAK1 FCGR2A FCGR2A MAP3K7 MAP3K7 NOS2 NOS2 TLR4 TLR4 HLA-DQB2 HLA-DQB2 TLR2 TLR2 LOC100358696 LOC100358696 ITGB1 ITGB1 TGFB2 TGFB2 JAK1 JAK1 TNF TNF EEF1A1 EEF1A1 HLA-DPB1 HLA-DPB1 IL1A IL1A MARCKSL1 MARCKSL1 HLA-DRA HLA-DRA TGFB3 TGFB3 TAB2 TAB2 IFNGR1 IFNGR1 MAPK1 MAPK1 MAPK3 MAPK3 NFKBIA NFKBIA IL12B IL12B G1TC56_RABIT G1TC56_RABIT PTGS2 PTGS2 JAK2 JAK2 TAB1 TAB1 HLA-DMA HLA-DMA NFKBIB NFKBIB IGHM-2 IGHM-2 IRAK4 IRAK4 LOC103345451 LOC103345451 MAPK12 MAPK12 MYD88 MYD88 ENSOCUP00000035377 ENSOCUP00000035377 LOC100338913 LOC100338913 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000037393 ENSOCUP00000037393 STAT1 STAT1 ITGB2 ITGB2 JUN JUN PTPN6 PTPN6 ENSOCUP00000041377 ENSOCUP00000041377 ELK1 ELK1 LOC100349667 LOC100349667 ENSOCUP00000044284 ENSOCUP00000044284 PRKCB PRKCB ENSOCUP00000046413 ENSOCUP00000046413 HLA-DOB HLA-DOB MAPK13 MAPK13 NCF2 NCF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
NCF4P40-phox. (340 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
RLA-DMBIg-like domain-containing protein. (257 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
G1TYN5_RABITIg-like domain-containing protein. (119 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
IFNGR2Interferon gamma receptor 2. (449 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
LOC100337909Uncharacterized protein. (325 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1258 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (534 aa)
FCGR2AUncharacterized protein. (323 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1146 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (305 aa)
TLR2TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa)
LOC100358696Uncharacterized protein. (397 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (830 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
JAK1Tyrosine-protein kinase. (1151 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
EEF1A1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. (462 aa)
HLA-DPB1RLA class II histocompatibility antigen, DP beta chain. (253 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
MARCKSL1MARCKS-related protein; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (By similarity). When unphosphorylated, induces cell migration (By similarity). When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity). May be involved in coupling the protein kinase C and calmodulin signal transduction systems (Probable). (189 aa)
HLA-DRAIntegral membrane protein; Belongs to the MHC class II family. (255 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IFNGR1Interferon gamma receptor 1. (471 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (234 aa)
NFKBIBNFKB inhibitor beta. (356 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (464 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
MAPK12Mitogen-activated protein kinase. (416 aa)
MYD88Uncharacterized protein. (476 aa)
ENSOCUP00000035377Ig-like domain-containing protein. (160 aa)
LOC100338913Uncharacterized protein. (325 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000037393Uncharacterized protein. (92 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
ITGB2Integrin beta. (1009 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
PTPN6Protein tyrosine phosphatase non-receptor type 6. (561 aa)
ENSOCUP00000041377Ig-like domain-containing protein. (148 aa)
ELK1ETS transcription factor ELK1. (512 aa)
LOC100349667Ig-like domain-containing protein. (292 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
PRKCBProtein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa)
ENSOCUP00000046413MHC_II_beta domain-containing protein. (169 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (265 aa)
MAPK13Mitogen-activated protein kinase. (399 aa)
NCF2Uncharacterized protein. (542 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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