STRINGSTRING
HLA-DQB2 HLA-DQB2 KRT17 KRT17 PLG PLG LOC100358696 LOC100358696 C5 C5 DSG1 DSG1 C2 C2 CFB CFB C4A C4A C3AR1 C3AR1 FPR1 FPR1 HLA-DPB1 HLA-DPB1 KRT25 KRT25 KRT26 KRT26 HLA-DRA HLA-DRA MBL2 MBL2 KRT32 KRT32 KRT35 KRT35 LOC100340088 LOC100340088 KRT33A KRT33A KRT34 KRT34 KRT38 KRT38 ITGAL ITGAL C1S C1S KRT28 KRT28 CAMP CAMP KRT39 KRT39 KRT40 KRT40 KRT12 KRT12 KRT23 KRT23 PTAFR PTAFR HLA-DMA HLA-DMA CS-6 CS-6 LOC100343422-2 LOC100343422-2 G1TM30_RABIT G1TM30_RABIT IGHM-2 IGHM-2 IL10 IL10 LOC108175984 LOC108175984 DEF5_RABIT DEF5_RABIT DEFB1 DEFB1 RLA-DMB RLA-DMB G1TYN5_RABIT G1TYN5_RABIT C5AR1 C5AR1 KRT18 KRT18 IGHM-3 IGHM-3 ICAM1 ICAM1 MCP2 MCP2 LOC100337909 LOC100337909 ITGAM ITGAM CFI CFI FCGR2A FCGR2A FGG FGG ENSOCUP00000035377 ENSOCUP00000035377 LOC100338913 LOC100338913 ENSOCUP00000037393 ENSOCUP00000037393 LOC100359306 LOC100359306 ITGB2 ITGB2 MASP1 MASP1 ENSOCUP00000041377 ENSOCUP00000041377 KRT10 KRT10 LOC100349667 LOC100349667 FPR2 FPR2 ENSOCUP00000046413 ENSOCUP00000046413 HLA-DOB HLA-DOB SELPLG SELPLG CFH CFH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (305 aa)
KRT17Keratin 17; Belongs to the intermediate filament family. (432 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (774 aa)
LOC100358696Uncharacterized protein. (397 aa)
C5Complement C5. (1678 aa)
DSG1Desmoglein 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1093 aa)
C2Complement C2; Belongs to the peptidase S1 family. (744 aa)
CFBUncharacterized protein; Belongs to the peptidase S1 family. (764 aa)
C4AUncharacterized protein. (1743 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (480 aa)
FPR1fMet-Leu-Phe receptor; High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (By similarity). (352 aa)
HLA-DPB1RLA class II histocompatibility antigen, DP beta chain. (253 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (450 aa)
KRT26Keratin 26; Belongs to the intermediate filament family. (462 aa)
HLA-DRAIntegral membrane protein; Belongs to the MHC class II family. (255 aa)
MBL2Mannose binding lectin 2. (247 aa)
KRT32Keratin 32; Belongs to the intermediate filament family. (447 aa)
KRT35Keratin 35; Belongs to the intermediate filament family. (455 aa)
LOC100340088IF rod domain-containing protein; Belongs to the intermediate filament family. (404 aa)
KRT33AKeratin 33A; Belongs to the intermediate filament family. (404 aa)
KRT34Keratin 34; Belongs to the intermediate filament family. (435 aa)
KRT38IF rod domain-containing protein; Belongs to the intermediate filament family. (456 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1241 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (690 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (459 aa)
CAMPAntimicrobial protein CAP18; CAP18 binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Has antibiotic activity. (171 aa)
KRT39Keratin 39; Belongs to the intermediate filament family. (480 aa)
KRT40Keratin 40; Belongs to the intermediate filament family. (431 aa)
KRT12Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity); Belongs to the intermediate filament family. (483 aa)
KRT23Keratin 23; Belongs to the intermediate filament family. (422 aa)
PTAFRPlatelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (342 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (234 aa)
CS-6Neutrophil antibiotic peptide NP-5; Microbicidal activity; Belongs to the alpha-defensin family. (95 aa)
LOC100343422-2IF rod domain-containing protein; Belongs to the intermediate filament family. (434 aa)
G1TM30_RABITUncharacterized protein. (246 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
LOC108175984Uncharacterized protein. (67 aa)
DEF5_RABITNeutrophil antibiotic peptide NP-4; Microbicidal activity; Belongs to the alpha-defensin family. (128 aa)
DEFB1Uncharacterized protein. (101 aa)
RLA-DMBIg-like domain-containing protein. (257 aa)
G1TYN5_RABITIg-like domain-containing protein. (119 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity). (348 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (431 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
ICAM1Intercellular adhesion molecule 1. (534 aa)
MCP2Corticostatin-4; This peptide has antibiotic, anti-fungi and antiviral activity. It also inhibits corticotropin (ACTH) stimulated corticosterone production; Belongs to the alpha-defensin family. (128 aa)
LOC100337909Uncharacterized protein. (325 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1258 aa)
CFIUncharacterized protein; Belongs to the peptidase S1 family. (605 aa)
FCGR2AUncharacterized protein. (323 aa)
FGGFibrinogen gamma chain. (450 aa)
ENSOCUP00000035377Ig-like domain-containing protein. (160 aa)
LOC100338913Uncharacterized protein. (325 aa)
ENSOCUP00000037393Uncharacterized protein. (92 aa)
LOC100359306Uncharacterized protein. (360 aa)
ITGB2Integrin beta. (1009 aa)
MASP1Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (738 aa)
ENSOCUP00000041377Ig-like domain-containing protein. (148 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (553 aa)
LOC100349667Ig-like domain-containing protein. (292 aa)
FPR2Formyl peptide receptor 2; Belongs to the G-protein coupled receptor 1 family. (476 aa)
ENSOCUP00000046413MHC_II_beta domain-containing protein. (169 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (265 aa)
SELPLGUncharacterized protein. (473 aa)
CFHUncharacterized protein. (1806 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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