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| | LOC100356250 | Uncharacterized protein. (292 aa) |
| | LOC100354468 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (234 aa) |
| | LOC100346856 | Uncharacterized protein. (316 aa) |
| | VDR | Vitamin D receptor. (368 aa) |
| | CEBPB | CCAAT enhancer binding protein beta. (353 aa) |
| | LOC100355669 | Uncharacterized protein. (190 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | LOC100354654 | Uncharacterized protein. (189 aa) |
| | LOC100341515 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | G1TM30_RABIT | Uncharacterized protein. (246 aa) |
| | LOC100357194 | Uncharacterized protein. (189 aa) |
| | IGHM-2 | Ig-like domain-containing protein. (167 aa) |
| | TRADD | TNFRSF1A associated via death domain. (447 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (412 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (518 aa) |
| | LOC100353673 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | CASP10 | Caspase-10; Belongs to the peptidase C14A family. (469 aa) |
| | LOC100348967 | Uncharacterized protein. (316 aa) |
| | IFNB1 | Interferon beta 1. (180 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (255 aa) |
| | G1TUQ7_RABIT | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | LOC108178730 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa) |
| | RLA-DMB | Ig-like domain-containing protein. (257 aa) |
| | LOC100357840 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | G1TYN5_RABIT | Ig-like domain-containing protein. (119 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (647 aa) |
| | IGHM-3 | Ig-like domain-containing protein. (167 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (449 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (540 aa) |
| | NFYC | Nuclear transcription factor Y subunit gamma. (469 aa) |
| | LOC100337909 | Uncharacterized protein. (325 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (574 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1258 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (899 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1175 aa) |
| | SPHK1 | Sphingosine kinase 1. (455 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (534 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (628 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (439 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (384 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | RAB7A | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (207 aa) |
| | NOS2 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1146 aa) |
| | TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa) |
| | HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 1. (305 aa) |
| | LOC100353390 | Uncharacterized protein. (189 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (592 aa) |
| | MRC1 | Mannose receptor C-type 1. (1455 aa) |
| | LOC100353390-2 | Uncharacterized protein. (190 aa) |
| | TLR2 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa) |
| | LOC100358696 | Uncharacterized protein. (397 aa) |
| | CD74 | CD74 molecule. (375 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (210 aa) |
| | CREBBP | CREB binding protein. (2403 aa) |
| | IL18 | Uncharacterized protein. (408 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (283 aa) |
| | TLR6 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (795 aa) |
| | JAK1 | Tyrosine-protein kinase. (1151 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | KSR1 | Kinase suppressor of ras 1. (851 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (265 aa) |
| | IL23A | Interleukin 23 subunit alpha. (191 aa) |
| | HLA-DPB1 | RLA class II histocompatibility antigen, DP beta chain. (253 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa) |
| | HLA-DRA | Integral membrane protein; Belongs to the MHC class II family. (255 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (218 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | CD209 | C-type lectin domain-containing protein. (239 aa) |
| | CTSS | Cathepsin S; Belongs to the peptidase C1 family. (340 aa) |
| | TGFB3 | Transforming growth factor beta 3. (458 aa) |
| | EP300 | E1A binding protein p300. (2418 aa) |
| | RFX5 | RFX-type winged-helix domain-containing protein. (664 aa) |
| | CALM1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | ATP6V0D1 | ATPase H+ transporting V0 subunit d1. (541 aa) |
| | APAF1 | Apoptotic peptidase activating factor 1. (1183 aa) |
| | RAB5A | Uncharacterized protein. (215 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | HSPD1 | Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (573 aa) |
| | NOD2 | Nucleotide oligomerization domain 2 protein. (1013 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (471 aa) |
| | RAB5C | Uncharacterized protein. (216 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | RAB5B | RAB5B, member RAS oncogene family. (290 aa) |
| | RFXAP | Regulatory factor X associated protein. (233 aa) |
| | PLA2R1 | Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marro [...] (1458 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa) |
| | CAMP | Antimicrobial protein CAP18; CAP18 binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Has antibiotic activity. (171 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (210 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa) |
| | G1TC56_RABIT | TGFb_propeptide domain-containing protein. (168 aa) |
| | CLEC7A | C-type lectin domain containing 7A. (247 aa) |
| | JAK2 | Tyrosine-protein kinase. (1132 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (150 aa) |
| | ITGAX | Integrin subunit alpha X; Belongs to the integrin alpha chain family. (1060 aa) |
| | SYK | Tyrosine-protein kinase. (630 aa) |
| | ATP6AP1 | Uncharacterized protein. (470 aa) |
| | CAMK2A | Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (469 aa) |
| | MRC2 | Mannose receptor C type 2. (1040 aa) |
| | MALT1 | MALT1 paracaspase. (799 aa) |
| | TIRAP | TIR domain containing adaptor protein. (234 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (85 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (416 aa) |
| | MYD88 | Uncharacterized protein. (476 aa) |
| | ENSOCUP00000035377 | Ig-like domain-containing protein. (160 aa) |
| | LOC100338913 | Uncharacterized protein. (325 aa) |
| | BCL2 | BH4_2 domain-containing protein. (389 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa) |
| | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. (263 aa) |
| | ENSOCUP00000037393 | Uncharacterized protein. (92 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (533 aa) |
| | LOC100359306 | Uncharacterized protein. (360 aa) |
| | STAT1 | Signal transducer and activator of transcription. (879 aa) |
| | ITGB2 | Integrin beta. (1009 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | ENSOCUP00000041377 | Ig-like domain-containing protein. (148 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | LOC100349667 | Ig-like domain-containing protein. (292 aa) |
| | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. (260 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (695 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (472 aa) |
| | ENSOCUP00000046413 | MHC_II_beta domain-containing protein. (169 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (265 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (466 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (399 aa) |
| | TLR9 | TIR domain-containing protein. (1027 aa) |
| | LBP | Lipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (496 aa) |
| | CASP8 | DED domain-containing protein. (109 aa) |
| | FCGR2A | Uncharacterized protein. (323 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (464 aa) |
| | LOC103345451 | TGFb_propeptide domain-containing protein. (203 aa) |
