Your Input: | |
| | CASP8 | DED domain-containing protein. (109 aa) |
| | CASP1 | Uncharacterized protein; Belongs to the peptidase C14A family. (418 aa) |
| | PLG | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (774 aa) |
| | PML | Promyelocytic leukemia. (860 aa) |
| | TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa) |
| | IRF7 | Interferon regulatory factor 7. (438 aa) |
| | HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 1. (305 aa) |
| | LOC100353390 | Uncharacterized protein. (189 aa) |
| | KPNA1 | Importin subunit alpha; Functions in nuclear protein import. (538 aa) |
| | CCL5 | C-C motif chemokine. (91 aa) |
| | LOC100353390-2 | Uncharacterized protein. (190 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | CREBBP | CREB binding protein. (2403 aa) |
| | PYCARD | PYD and CARD domain containing. (196 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | IL18 | Uncharacterized protein. (408 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1046 aa) |
| | LOC100339773 | Uncharacterized protein. (592 aa) |
| | JAK1 | Tyrosine-protein kinase. (1151 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | EIF2AK2 | Interferon-induced double-stranded RNA-activated protein kinase. (547 aa) |
| | KPNA5 | Importin subunit alpha; Functions in nuclear protein import. (577 aa) |
| | NXT2 | Nuclear transport factor 2 like export factor 2. (197 aa) |
| | NXF3 | Uncharacterized protein. (667 aa) |
| | PABPN1 | RRM domain-containing protein. (302 aa) |
| | HLA-DPB1 | RLA class II histocompatibility antigen, DP beta chain. (253 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa) |
| | HLA-DRA | Integral membrane protein; Belongs to the MHC class II family. (255 aa) |
| | VDAC1 | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (283 aa) |
| | TRIM25 | RING-type domain-containing protein. (368 aa) |
| | EP300 | E1A binding protein p300. (2418 aa) |
| | APAF1 | Apoptotic peptidase activating factor 1. (1183 aa) |
| | RSAD2 | Radical S-adenosyl methionine domain containing 2. (396 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (471 aa) |
| | SLC25A5 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | IL33 | Uncharacterized protein. (142 aa) |
| | LOC100345250 | Uncharacterized protein. (461 aa) |
| | TNFSF10 | Tumor necrosis factor ligand superfamily member. (304 aa) |
| | LOC100340535 | Uncharacterized protein. (644 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (320 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (685 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (529 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (210 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa) |
| | HNRNPUL1 | Heterogeneous nuclear ribonucleoprotein U like 1. (856 aa) |
| | JAK2 | Tyrosine-protein kinase. (1132 aa) |
| | TMPRSS4 | Transmembrane serine protease 4; Belongs to the peptidase S1 family. (437 aa) |
| | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3. (497 aa) |
| | KPNA6 | Importin subunit alpha; Functions in nuclear protein import. (536 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa) |
| | LOC100354468 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (234 aa) |
| | IFNAR2 | Uncharacterized protein. (523 aa) |
| | MX1 | Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (697 aa) |
| | LOC100355669 | Uncharacterized protein. (190 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | LOC100354654 | Uncharacterized protein. (189 aa) |
| | LOC100341515 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | NFKBIB | NFKB inhibitor beta. (356 aa) |
| | MX2 | Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (555 aa) |
| | LOC100357194 | Uncharacterized protein. (189 aa) |
| | CPSF4L | Cleavage and polyadenylation specific factor 4 like. (173 aa) |
| | TRADD | TNFRSF1A associated via death domain. (447 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | CYCS | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | DDX58 | DExD/H-box helicase 58. (954 aa) |
| | LOC100353673 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa) |
| | IFNB1 | Interferon beta 1. (180 aa) |
| | G1TUQ7_RABIT | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | LOC108178730 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa) |
| | RLA-DMB | Ig-like domain-containing protein. (257 aa) |
| | LOC100357840 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | SLC25A4 | ADP/ATP translocase 1; Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane; Belongs to the mitochondrial carrier (TC 2.A.29) family. (288 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | NXT1 | Nuclear transport factor 2 like export factor 1. (140 aa) |
| | TMPRSS11D | Transmembrane protease serine; Belongs to the peptidase S1 family. (418 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (449 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (210 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (541 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (534 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1044 aa) |
| | RAB11B | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (312 aa) |
| | XPO1 | Exportin 1. (1081 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1175 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (1057 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (464 aa) |
| | LOC103351963 | Uncharacterized protein. (775 aa) |
| | KPNA7 | Importin subunit alpha; Functions in nuclear protein import. (529 aa) |
| | FAS | Uncharacterized protein. (484 aa) |
| | MYD88 | Uncharacterized protein. (476 aa) |
| | TBK1 | TANK binding kinase 1. (836 aa) |
| | NXF1 | Nuclear RNA export factor 1. (660 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa) |
| | FDPS | Farnesyl diphosphate synthase. (558 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa) |
| | STAT1 | Signal transducer and activator of transcription. (879 aa) |
| | RAE1 | Ribonucleic acid export 1. (400 aa) |
| | STAT2 | STAT_int domain-containing protein. (205 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | PRSS2 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (257 aa) |
| | NUP98 | Nucleoporin 98. (1825 aa) |
| | LOC100349667 | Ig-like domain-containing protein. (292 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (358 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (472 aa) |
| | ACTB | Uncharacterized protein. (357 aa) |
| | PRKCB | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] (638 aa) |
| | ENSOCUP00000046413 | MHC_II_beta domain-containing protein. (169 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (265 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (466 aa) |
| | ENSOCUP00000047896 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (541 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1182 aa) |
