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| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | CD3G | IGc2 domain-containing protein. (182 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | LTBR | Lymphotoxin beta receptor. (414 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (406 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 1. (305 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | SRF | Serum response factor. (685 aa) |
| | ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa) |
| | BCL2L1 | Bcl-X. (233 aa) |
| | ZFP36 | ZFP36 ring finger protein. (338 aa) |
| | CSF2 | Uncharacterized protein. (144 aa) |
| | LCK | Tyrosine-protein kinase. (637 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (210 aa) |
| | CREBBP | CREB binding protein. (2403 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (950 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | STAT5B | Signal transducer and activator of transcription. (786 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (405 aa) |
| | CREB1 | cAMP responsive element binding protein 1. (341 aa) |
| | G1SPA3_RABIT | Uncharacterized protein. (226 aa) |
| | JAK1 | Tyrosine-protein kinase. (1151 aa) |
| | IL15RA | Sushi domain-containing protein. (262 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | NFATC1 | RHD domain-containing protein. (672 aa) |
| | G1SR88_RABIT | Ig-like domain-containing protein; Belongs to the MHC class I family. (264 aa) |
| | LTA | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. (197 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (699 aa) |
| | TBPL1 | Uncharacterized protein. (363 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa) |
| | LOC100358749 | Sushi domain-containing protein. (272 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1236 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (700 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1040 aa) |
| | HLA-DPB1 | RLA class II histocompatibility antigen, DP beta chain. (253 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa) |
| | HLA-DRA | Integral membrane protein; Belongs to the MHC class II family. (255 aa) |
| | MSX2 | Msh homeobox 2. (268 aa) |
| | VDAC1 | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (283 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1070 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa) |
| | TLN1 | Talin 1. (2558 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | TGFB3 | Transforming growth factor beta 3. (458 aa) |
| | EP300 | E1A binding protein p300. (2418 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (395 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (138 aa) |
| | CDK4 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa) |
| | TLN2 | Talin 2. (2536 aa) |
| | SLC25A5 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | EGR2 | Early growth response 2. (549 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (597 aa) |
| | CRTC3 | CREB regulated transcription coactivator 3. (621 aa) |
| | LOC100345250 | Uncharacterized protein. (461 aa) |
| | E2F3 | E2F transcription factor 3. (462 aa) |
| | ITGAL | Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1241 aa) |
| | ELK4 | ETS transcription factor ELK4. (433 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | TBPL2 | TATA-box binding protein like 2. (379 aa) |
| | PTTG1 | Uncharacterized protein. (201 aa) |
| | ADCY5 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1010 aa) |
| | MMP7 | Matrix metallopeptidase 7. (273 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1138 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (320 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | CRTC2 | CREB regulated transcription coactivator 2. (652 aa) |
| | CCNA1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (423 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa) |
| | CDKN1A | Uncharacterized protein. (231 aa) |
| | G1TC56_RABIT | TGFb_propeptide domain-containing protein. (168 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (425 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (120 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (328 aa) |
| | RAN | GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (128 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1944 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (234 aa) |
| | RANBP1 | RAN binding protein 1. (266 aa) |
| | LOC100357230 | GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (165 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | VDAC3 | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (284 aa) |
| | IL2RG | Uncharacterized protein. (171 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | ANAPC11 | RING-type domain-containing protein. (84 aa) |
| | CD3E | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (201 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (518 aa) |
| | ETS2 | ETS proto-oncogene 2, transcription factor; Transcription factor; Belongs to the ETS family. (468 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (424 aa) |
| | ATF6B | Activating transcription factor 6 beta. (622 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | CDC27 | Cell division cycle 27. (825 aa) |
| | GPS2 | G protein pathway suppressor 2. (327 aa) |
| | LOC100340625 | ANK_REP_REGION domain-containing protein. (324 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | TBP | TATA-box binding protein. (323 aa) |
| | RLA-DMB | Ig-like domain-containing protein. (257 aa) |
| | CALR | Calreticulin. (413 aa) |
| | SLC25A4 | ADP/ATP translocase 1; Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane; Belongs to the mitochondrial carrier (TC 2.A.29) family. (288 aa) |
| | VAC14 | VAC14 component of PIKFYVE complex. (778 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | STAT5A | Signal transducer and activator of transcription. (793 aa) |
| | ETS1 | Uncharacterized protein. (533 aa) |
| | CANX | Calnexin. (622 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3848 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (512 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (534 aa) |
| | SMAD3 | SMAD family member 3. (230 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (574 aa) |
| | XIAP | RING-type domain-containing protein. (633 aa) |
| | XPO1 | Exportin 1. (1081 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (933 aa) |
| | CD4 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa) |
| | RANBP3 | RAN binding protein 3. (675 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (439 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (1057 aa) |
| | MAD1L1 | Uncharacterized protein. (434 aa) |
| | LOC103345451 | TGFb_propeptide domain-containing protein. (203 aa) |
| | ENSOCUP00000033540 | Ig-like domain-containing protein. (203 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (377 aa) |
| | CD40 | Uncharacterized protein. (494 aa) |
| | E2F2 | E2F transcription factor 2. (440 aa) |
| | CREB5 | cAMP responsive element binding protein 5. (526 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4. (520 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1408 aa) |
| | FDPS | Farnesyl diphosphate synthase. (558 aa) |
| | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3. (681 aa) |
| | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. (263 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (620 aa) |
| | ITGB2 | Integrin beta. (1009 aa) |
| | FOSL1 | FOS like 1, AP-1 transcription factor subunit. (335 aa) |
| | JUN | BZIP domain-containing protein; Belongs to the bZIP family. (352 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (584 aa) |
| | CD3D | Ig_4 domain-containing protein. (177 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa) |
| | RB1 | RB transcriptional corepressor 1. (943 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | ELK1 | ETS transcription factor ELK1. (512 aa) |
| | LOC100355380 | Ig-like domain-containing protein; Belongs to the MHC class I family. (445 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa) |
| | TSPO | Uncharacterized protein. (516 aa) |
| | LOC100349667 | Ig-like domain-containing protein. (292 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2151 aa) |
| | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. (260 aa) |
| | LOC100338113 | Uncharacterized protein. (282 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (900 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (695 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (472 aa) |
| | LOC100349085 | Ig-like domain-containing protein; Belongs to the MHC class I family. (418 aa) |
| | BUB1B | Uncharacterized protein. (1063 aa) |
| | ENSOCUP00000046413 | MHC_II_beta domain-containing protein. (169 aa) |
| | HLA-DOB | Major histocompatibility complex, class II, DO beta. (265 aa) |
| | VDAC2 | Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules. (439 aa) |
| | ENSOCUP00000049983 | Uncharacterized protein. (319 aa) |
