STRINGSTRING
LOC100345250 LOC100345250 TP53 TP53 DDB2 DDB2 POLK POLK SMAD4 SMAD4 PIK3CB PIK3CB PIK3R1 PIK3R1 TGFB2 TGFB2 RALB RALB SOS2 SOS2 BAX BAX APPL1 APPL1 GADD45A GADD45A MSH2 MSH2 RAC1 RAC1 EGFR EGFR MAPK10 MAPK10 SMAD2 SMAD2 TGFB3 TGFB3 KRAS KRAS MTOR MTOR GADD45G GADD45G RHOA RHOA MAPK1 MAPK1 MAPK3 MAPK3 MYC MYC LOC100348967 LOC100348967 G1TUQ7_RABIT G1TUQ7_RABIT PIK3CD PIK3CD LOC108178730 LOC108178730 FOS FOS LOC100357840 LOC100357840 RALA-2 RALA-2 LOC103347195 LOC103347195 PIK3CA PIK3CA BAK1 BAK1 SMAD3 SMAD3 MAP2K1 MAP2K1 MAPK9 MAPK9 LOC103345451 LOC103345451 BIRC5 BIRC5 GSK3B GSK3B TGFA TGFA TGFBR1 TGFBR1 BCL2 BCL2 RAF1 RAF1 CASP3 CASP3 ENSOCUP00000037329 ENSOCUP00000037329 MLH1 MLH1 JUN JUN AKT3 AKT3 DCC DCC GRB2 GRB2 ENSOCUP00000044284 ENSOCUP00000044284 CASP9 CASP9 ENSOCUP00000048975 ENSOCUP00000048975 LEF1 LEF1 MSH6 MSH6 APC APC TCF7 TCF7 CDKN1A CDKN1A EREG EREG AREG AREG EGF EGF ARAF ARAF G1TC56_RABIT G1TC56_RABIT LOC103346586 LOC103346586 MSH3 MSH3 G1TEV7_RABIT G1TEV7_RABIT LOC100356250 LOC100356250 LOC100354468 LOC100354468 LOC100346856 LOC100346856 LOC100341515 LOC100341515 MAPK8 MAPK8 CYCS CYCS NRAS NRAS SOS1 SOS1 LOC100353673 LOC100353673
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100345250Uncharacterized protein. (461 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
POLKUmuC domain-containing protein. (385 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RALBRAS like proto-oncogene B. (242 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (865 aa)
RAC1Rac family small GTPase 1. (199 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (149 aa)
RHOARas homolog family member A. (193 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
LOC100348967Uncharacterized protein. (316 aa)
G1TUQ7_RABITCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
LOC108178730Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC100357840Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
RALA-2Uncharacterized protein. (206 aa)
LOC103347195Ras-GEF domain-containing protein. (538 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BAK1BCL2 antagonist/killer 1. (210 aa)
SMAD3SMAD family member 3. (230 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
MAPK9Mitogen-activated protein kinase. (439 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
BIRC5Uncharacterized protein. (164 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
TGFATransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar (By similarity). Inhibitor of acid secretion. Inhibitor of aminopyrine uptake in parietal cells (in vitro). (185 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (346 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
MLH1MutL homolog 1. (800 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
DCCDCC netrin 1 receptor. (1425 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (466 aa)
ENSOCUP00000048975Ras-GEF domain-containing protein. (468 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
APCAPC regulator of WNT signaling pathway. (2871 aa)
TCF7Transcription factor 7. (319 aa)
CDKN1AUncharacterized protein. (231 aa)
EREGEpiregulin. (169 aa)
AREGAmphiregulin. (275 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
LOC103346586Ras-GEF domain-containing protein. (538 aa)
MSH3MutS homolog 3. (1019 aa)
G1TEV7_RABITRas-GEF domain-containing protein. (519 aa)
LOC100356250Uncharacterized protein. (292 aa)
LOC100354468Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC100346856Uncharacterized protein. (316 aa)
LOC100341515Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
LOC100353673Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (153 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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