STRINGSTRING
ARAF ARAF PDGFRA PDGFRA TP53 TP53 SRD5A2 SRD5A2 PDGFRB PDGFRB PDPK1 PDPK1 GSTP1 GSTP1 NKX3-1 NKX3-1 CREBBP CREBBP PIK3CB PIK3CB PIK3R1 PIK3R1 ETV5 ETV5 CCNE2 CCNE2 CREB1 CREB1 PDGFA PDGFA SOS2 SOS2 ZEB1 ZEB1 IKBKB IKBKB PTEN PTEN SLC35E3 SLC35E3 EGFR EGFR ERBB2 ERBB2 INSRR INSRR EP300 EP300 CREB3L4 CREB3L4 KRAS KRAS MTOR MTOR MAPK1 MAPK1 MAPK3 MAPK3 CDKN1B CDKN1B LOC100345250 LOC100345250 E2F3 E2F3 FOXO1 FOXO1 HSP90AB1 HSP90AB1 MMP3 MMP3 PDGFD PDGFD NFKBIA NFKBIA TCF7 TCF7 CDKN1A CDKN1A HSP90B1 HSP90B1 EGF EGF IL1R2 IL1R2 PDGFC PDGFC NRAS NRAS SOS1 SOS1 INS INS PIK3CD PIK3CD IGF1 IGF1 PLAU PLAU NFKB1 NFKB1 MMP9 MMP9 PIK3CA PIK3CA PDGFB PDGFB MAP2K1 MAP2K1 CHUK CHUK CREB3 CREB3 FGFR2 FGFR2 E2F2 E2F2 GSK3B GSK3B CREB5 CREB5 TGFA TGFA BCL2 BCL2 RAF1 RAF1 CREB3L2 CREB3L2 RB1 RB1 AKT3 AKT3 FGFR1 FGFR1 GRB2 GRB2 AR AR PLAT PLAT IKBKG IKBKG CASP9 CASP9 ERG ERG LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
PDGFRAProtein kinase domain-containing protein. (773 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
PDPK13-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily. (325 aa)
GSTP1Uncharacterized protein. (436 aa)
NKX3-1NK3 homeobox 1. (159 aa)
CREBBPCREB binding protein. (2403 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ETV5ETS variant 5. (569 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PDGFAPlatelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] (150 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1080 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SLC35E3Uncharacterized protein. (767 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
INSRRTyrosine-protein kinase receptor. (1320 aa)
EP300E1A binding protein p300. (2418 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LOC100345250Uncharacterized protein. (461 aa)
E2F3E2F transcription factor 3. (462 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
HSP90AB1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (726 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
PDGFDPlatelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). (538 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TCF7Transcription factor 7. (319 aa)
CDKN1AUncharacterized protein. (231 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. (802 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
IL1R2Interleukin 1 receptor type 2. (425 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. (433 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
CREB3cAMP responsive element binding protein 3. (377 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
E2F2E2F transcription factor 2. (440 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
CREB5cAMP responsive element binding protein 5. (526 aa)
TGFATransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar (By similarity). Inhibitor of acid secretion. Inhibitor of aminopyrine uptake in parietal cells (in vitro). (185 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (584 aa)
RB1RB transcriptional corepressor 1. (943 aa)
AKT3Non-specific serine/threonine protein kinase. (511 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
GRB2Growth factor receptor bound protein 2. (278 aa)
ARAndrogen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (925 aa)
PLATUncharacterized protein. (594 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (466 aa)
ERGETS transcription factor ERG. (545 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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