STRINGSTRING
MAPK1 MAPK1 TP53 TP53 TYMP TYMP THBS1 THBS1 RPS6KA5 RPS6KA5 SLC35E3 SLC35E3 EGFR EGFR ERBB2 ERBB2 VEGFA VEGFA KRAS KRAS CDK4 CDK4 MAPK3 MAPK3 MYC MYC E2F3 E2F3 CDKN1A CDKN1A EGF EGF ARAF ARAF UPK3A UPK3A CXCL8 CXCL8 NRAS NRAS LOC100340625 LOC100340625 RASSF1 RASSF1 CDH1 CDH1 MMP9 MMP9 MAP2K1 MAP2K1 E2F2 E2F2 MMP1 MMP1 RAF1 RAF1 RB1 RB1 DAPK2 DAPK2 DAPK1 DAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK1Mitogen-activated protein kinase. (364 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (434 aa)
THBS1Thrombospondin 1. (1171 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
SLC35E3Uncharacterized protein. (767 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa)
MAPK3Mitogen-activated protein kinase. (381 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
E2F3E2F transcription factor 3. (462 aa)
CDKN1AUncharacterized protein. (231 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
UPK3AUroplakin 3A. (287 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC100340625ANK_REP_REGION domain-containing protein. (324 aa)
RASSF1Uncharacterized protein. (189 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (884 aa)
MMP9Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
E2F2E2F transcription factor 2. (440 aa)
MMP1Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
RB1RB transcriptional corepressor 1. (943 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
DAPK1Death associated protein kinase 1. (1493 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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