62 items (Oryctolagus cuniculus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
	DDB2	Damage specific DNA binding protein 2. (427 aa)
	POLK	UmuC domain-containing protein. (385 aa)
	BCL2L1	Bcl-X. (233 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	CBL	Cbl proto-oncogene. (837 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	STAT5B	Signal transducer and activator of transcription. (786 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	GADD45A	Growth arrest and DNA damage inducible alpha. (165 aa)
	SLC35E3	Uncharacterized protein. (767 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (149 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	MAPK3	Mitogen-activated protein kinase. (381 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (466 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
	LOC100345250	Uncharacterized protein. (461 aa)
	E2F3	E2F transcription factor 3. (462 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	CDKN1A	Uncharacterized protein. (231 aa)
	SHC1	SHC adaptor protein 1. (474 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	G1TC56_RABIT	TGFb_propeptide domain-containing protein. (168 aa)
	GAB2	GRB2 associated binding protein 2. (679 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
	LOC100340625	ANK_REP_REGION domain-containing protein. (324 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (968 aa)
	STAT5A	Signal transducer and activator of transcription. (793 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	BAK1	BCL2 antagonist/killer 1. (210 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1192 aa)
	SMAD3	SMAD family member 3. (230 aa)
	MECOM	MDS1 and EVI1 complex locus. (1226 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (1057 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	E2F2	E2F transcription factor 2. (440 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (701 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (686 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (550 aa)
	CTBP2	C-terminal binding protein 2. (981 aa)
	ABL1	Tyrosine-protein kinase. (1118 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa)
	RB1	RB transcriptional corepressor 1. (943 aa)
	AKT3	Non-specific serine/threonine protein kinase. (511 aa)
	GRB2	Growth factor receptor bound protein 2. (278 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCR	ENSOCUP00000038489	ENSOCUP00000027066	Tyrosine-protein kinase.	BCR activator of RhoGEF and GTPase.	0.948
ABL1	CBL	ENSOCUP00000038489	ENSOCUP00000004160	Tyrosine-protein kinase.	Cbl proto-oncogene.	0.959
ABL1	CDK4	ENSOCUP00000038489	ENSOCUP00000010738	Tyrosine-protein kinase.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.425
ABL1	CDK6	ENSOCUP00000038489	ENSOCUP00000039381	Tyrosine-protein kinase.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.404
ABL1	CDKN1A	ENSOCUP00000038489	ENSOCUP00000013788	Tyrosine-protein kinase.	Uncharacterized protein.	0.583
ABL1	CDKN1B	ENSOCUP00000038489	ENSOCUP00000012008	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1B.	0.532
ABL1	CRKL	ENSOCUP00000038489	ENSOCUP00000000710	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.987
ABL1	GRB2	ENSOCUP00000038489	ENSOCUP00000042433	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.968
ABL1	KRAS	ENSOCUP00000038489	ENSOCUP00000010411	Tyrosine-protein kinase.	KRAS proto-oncogene, GTPase.	0.538
ABL1	LOC100340625	ENSOCUP00000038489	ENSOCUP00000021423	Tyrosine-protein kinase.	ANK_REP_REGION domain-containing protein.	0.543
ABL1	MAPK1	ENSOCUP00000038489	ENSOCUP00000011783	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.452
ABL1	MAPK3	ENSOCUP00000038489	ENSOCUP00000011800	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.435
ABL1	NRAS	ENSOCUP00000038489	ENSOCUP00000019559	Tyrosine-protein kinase.	NRAS proto-oncogene, GTPase.	0.609
ABL1	PIK3CA	ENSOCUP00000038489	ENSOCUP00000026298	Tyrosine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.554
ABL1	PIK3R1	ENSOCUP00000038489	ENSOCUP00000004433	Tyrosine-protein kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.475
ABL1	PTPN11	ENSOCUP00000038489	ENSOCUP00000003911	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.699
ABL1	RB1	ENSOCUP00000038489	ENSOCUP00000041017	Tyrosine-protein kinase.	RB transcriptional corepressor 1.	0.937
ABL1	RUNX1	ENSOCUP00000038489	ENSOCUP00000011814	Tyrosine-protein kinase.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.697
ABL1	SHC1	ENSOCUP00000038489	ENSOCUP00000013916	Tyrosine-protein kinase.	SHC adaptor protein 1.	0.941
ABL1	SHC4	ENSOCUP00000038489	ENSOCUP00000005567	Tyrosine-protein kinase.	SHC adaptor protein 4.	0.919