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| | LEF1 | Lymphoid enhancer binding factor 1. (414 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | CDKN1A | Uncharacterized protein. (231 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa) |
| | SHC1 | SHC adaptor protein 1. (474 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (606 aa) |
| | G1TC56_RABIT | TGFb_propeptide domain-containing protein. (168 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa) |
| | RXRB | Retinoid X receptor beta. (541 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (397 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (587 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa) |
| | CDH1 | Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (884 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (538 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa) |
| | FZD8 | G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (303 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (210 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa) |
| | SMAD3 | SMAD family member 3. (230 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] (396 aa) |
| | HGF | Heptapoietin A light chain; HPTA is an acidic heparin-binding growth factor for hepatocytes. (761 aa) |
| | LOC103345451 | TGFb_propeptide domain-containing protein. (203 aa) |
| | CTNNA2 | Catenin alpha 2. (953 aa) |
| | CTNNA3 | Catenin alpha 3. (895 aa) |
| | ABCB1 | Uncharacterized protein. (1388 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa) |
| | FGF18 | Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (894 aa) |
| | E2F2 | E2F transcription factor 2. (440 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa) |
| | BCL2 | BH4_2 domain-containing protein. (389 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (701 aa) |
| | REG4 | Regenerating family member 4. (192 aa) |
| | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. (263 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | MLH1 | MutL homolog 1. (800 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (469 aa) |
| | RB1 | RB transcriptional corepressor 1. (943 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (511 aa) |
| | FGF17 | Uncharacterized protein; Belongs to the heparin-binding growth factors family. (151 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (278 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa) |
| | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. (260 aa) |
| | LOC100352479 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (332 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (431 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa) |
| | WNT5A | Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa) |
| | RARB | Retinoic acid receptor beta. (448 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | WNT8B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | CDH17 | Cadherin 17. (836 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | POLK | UmuC domain-containing protein. (385 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | GAB1 | GRB2 associated binding protein 1. (750 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1540 aa) |
| | FGF19 | Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (218 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | CDX2 | Caudal type homeobox 2. (314 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (405 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1321 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | CTNNA1 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] (993 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa) |
| | GADD45A | Growth arrest and DNA damage inducible alpha. (165 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1193 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (467 aa) |
| | TGFB3 | Transforming growth factor beta 3. (458 aa) |
| | JUP | Junction plakoglobin. (745 aa) |
| | KRAS | KRAS proto-oncogene, GTPase. (189 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (138 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (149 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (364 aa) |
| | MAPK3 | Mitogen-activated protein kinase. (381 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa) |
| | LOC100345250 | Uncharacterized protein. (461 aa) |
| | E2F3 | E2F transcription factor 3. (462 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (668 aa) |
| | APC | APC regulator of WNT signaling pathway. (2871 aa) |
| | TCF7 | Transcription factor 7. (319 aa) |
