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ATP6V1G3 ATP6V1G3 LOC100348776 LOC100348776 CCL20 CCL20 ATP6V1B2 ATP6V1B2 TLR4 TLR4 HLA-DQB2 HLA-DQB2 CCL5 CCL5 TLR2 TLR2 CSF2 CSF2 IL17A IL17A IL18 IL18 TGFB2 TGFB2 PTH PTH ATP6V0B ATP6V0B ATP6V0E1 ATP6V0E1 TNF TNF LTB LTB ATP6V1E1 ATP6V1E1 ATP6V0C ATP6V0C IL23A IL23A HLA-DPB1 HLA-DPB1 IL1A IL1A IL15 IL15 HLA-DRA HLA-DRA CD80 CD80 ATP6V0D2 ATP6V0D2 CTSK CTSK TGFB3 TGFB3 VEGFA VEGFA ATP6V0D1 ATP6V0D1 TNLG7A TNLG7A ATP6V0A4 ATP6V0A4 ATP6V1F ATP6V1F ITGAL ITGAL ATP6V0E2 ATP6V0E2 ATP6V0A1 ATP6V0A1 MMP3 MMP3 ATP6V1H ATP6V1H G1TC56_RABIT G1TC56_RABIT LOC100347623 LOC100347623 ATP6AP1 ATP6AP1 LOC100356256 LOC100356256 TNFSF11 TNFSF11 CCL2 CCL2 HLA-DMA HLA-DMA FLT1 FLT1 IL6 IL6 CTLA4 CTLA4 IGHM-2 IGHM-2 CXCL8 CXCL8 TNFSF13 TNFSF13 FOS FOS IL1B IL1B RLA-DMB RLA-DMB G1TYN5_RABIT G1TYN5_RABIT ATP6V1G2 ATP6V1G2 CD28 CD28 ATP6V1G1 ATP6V1G1 IGHM-3 IGHM-3 CSF1 CSF1 LOC100344030 LOC100344030 LOC100358984 LOC100358984 ICAM1 ICAM1 ATP6V1C2 ATP6V1C2 GRO-B GRO-B ATP6V0A2 ATP6V0A2 LOC103345451 LOC103345451 ATP6V1D ATP6V1D CD86 CD86 ENSOCUP00000035377 ENSOCUP00000035377 MMP1 MMP1 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000037393 ENSOCUP00000037393 CTSV CTSV ITGB2 ITGB2 JUN JUN ENSOCUP00000041377 ENSOCUP00000041377 LOC100349667 LOC100349667 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000046413 ENSOCUP00000046413 HLA-DOB HLA-DOB ANGPT1 ANGPT1 ATP6V1C1 ATP6V1C1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
LOC100348776C-C motif chemokine. (93 aa)
CCL20C-C motif chemokine. (96 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (305 aa)
CCL5C-C motif chemokine. (91 aa)
TLR2TIR domain-containing protein; Belongs to the Toll-like receptor family. (784 aa)
CSF2Uncharacterized protein. (144 aa)
IL17AInterleukin 17A. (153 aa)
IL18Uncharacterized protein. (408 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PTHParathyroid hormone. (131 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (283 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (247 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (265 aa)
IL23AInterleukin 23 subunit alpha. (191 aa)
HLA-DPB1RLA class II histocompatibility antigen, DP beta chain. (253 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
HLA-DRAIntegral membrane protein; Belongs to the MHC class II family. (255 aa)
CD80T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor. (299 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family. (329 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
ATP6V0D1ATPase H+ transporting V0 subunit d1. (541 aa)
TNLG7ATumor necrosis factor ligand 7A; Belongs to the tumor necrosis factor family. (362 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1241 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
G1TC56_RABITTGFb_propeptide domain-containing protein. (168 aa)
LOC100347623Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
ATP6AP1Uncharacterized protein. (470 aa)
LOC100356256Uncharacterized protein; Belongs to the peptidase C1 family. (369 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (234 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1479 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CTLA4Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa)
IGHM-2Ig-like domain-containing protein. (167 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
TNFSF13TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (250 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
RLA-DMBIg-like domain-containing protein. (257 aa)
G1TYN5_RABITIg-like domain-containing protein. (119 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (162 aa)
IGHM-3Ig-like domain-containing protein. (167 aa)
CSF1Colony stimulating factor 1. (535 aa)
LOC100344030Uncharacterized protein; Belongs to the peptidase C1 family. (344 aa)
LOC100358984Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (857 aa)
ICAM1Intercellular adhesion molecule 1. (534 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
GRO-BPermeability factor 2; Has chemotactic activity for neutrophils; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (628 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ATP6V1DV-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). (259 aa)
CD86T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. (336 aa)
ENSOCUP00000035377Ig-like domain-containing protein. (160 aa)
MMP1Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000037393Uncharacterized protein. (92 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (356 aa)
ITGB2Integrin beta. (1009 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
ENSOCUP00000041377Ig-like domain-containing protein. (148 aa)
LOC100349667Ig-like domain-containing protein. (292 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000046413MHC_II_beta domain-containing protein. (169 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (265 aa)
ANGPT1Angiopoietin 1. (551 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (387 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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